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Consequences of the crosstalk between monocytes/macrophages and natural killer cells.

Michel T, Hentges F, Zimmer J - Front Immunol (2013)

Bottom Line: The macrophage-NK interaction is a major first-line defense against pathogens (bacteria, viruses, fungi, and parasites).The recruitment and the activation of NK cells to perform cytotoxicity or produce cytokines at the sites of inflammation are important to fight infections.The two main mechanisms by which macrophages can prime NK cells are (1) activation through soluble mediators such as IL-12, IL-18, and (2) stimulation through direct cell-to-cell contact.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Immunogenetics and Allergology, Centre de Recherche Public de la Santé Luxembourg, Luxembourg.

ABSTRACT
The interaction between natural killer (NK) cells and different other immune cells like T cells and dendritic cells is well-described, but the crosstalk with monocytes or macrophages and the nature of ligands/receptors implicated are just emerging. The macrophage-NK interaction is a major first-line defense against pathogens (bacteria, viruses, fungi, and parasites). The recruitment and the activation of NK cells to perform cytotoxicity or produce cytokines at the sites of inflammation are important to fight infections. The two main mechanisms by which macrophages can prime NK cells are (1) activation through soluble mediators such as IL-12, IL-18, and (2) stimulation through direct cell-to-cell contact. We will discuss the progress in matters of modulation of NK cell functions by monocytes and macrophages, in the steady state and during diseases.

No MeSH data available.


Related in: MedlinePlus

Different macrophage-derivated signals that influence NK cell functions.
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Figure 1: Different macrophage-derivated signals that influence NK cell functions.

Mentions: The same capacity of IL-12 and IL-18 secreted by Kupffer cells to activate IFN-γ production by liver NK cells is found in human (Tu et al., 2008). The key role of IL-12 and IL-18 in NK cytotoxicity is confirmed in an experiment where PBMC-derived macrophages are infected with Salmonella (Lapaque et al., 2009). Furthermore, LPS, in presence of PBMC-derived macrophages, promotes the expression of IL-18 and consequently the synthesis of IFN-γ by NK cells (Bellora et al., 2012). Finally, S. aureus stimulated-monocytes from PBMC, produce IL-12 which participates to IFN-γ secretion by NK cells (Figure 1) (Haller et al., 2002).


Consequences of the crosstalk between monocytes/macrophages and natural killer cells.

Michel T, Hentges F, Zimmer J - Front Immunol (2013)

Different macrophage-derivated signals that influence NK cell functions.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3539656&req=5

Figure 1: Different macrophage-derivated signals that influence NK cell functions.
Mentions: The same capacity of IL-12 and IL-18 secreted by Kupffer cells to activate IFN-γ production by liver NK cells is found in human (Tu et al., 2008). The key role of IL-12 and IL-18 in NK cytotoxicity is confirmed in an experiment where PBMC-derived macrophages are infected with Salmonella (Lapaque et al., 2009). Furthermore, LPS, in presence of PBMC-derived macrophages, promotes the expression of IL-18 and consequently the synthesis of IFN-γ by NK cells (Bellora et al., 2012). Finally, S. aureus stimulated-monocytes from PBMC, produce IL-12 which participates to IFN-γ secretion by NK cells (Figure 1) (Haller et al., 2002).

Bottom Line: The macrophage-NK interaction is a major first-line defense against pathogens (bacteria, viruses, fungi, and parasites).The recruitment and the activation of NK cells to perform cytotoxicity or produce cytokines at the sites of inflammation are important to fight infections.The two main mechanisms by which macrophages can prime NK cells are (1) activation through soluble mediators such as IL-12, IL-18, and (2) stimulation through direct cell-to-cell contact.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Immunogenetics and Allergology, Centre de Recherche Public de la Santé Luxembourg, Luxembourg.

ABSTRACT
The interaction between natural killer (NK) cells and different other immune cells like T cells and dendritic cells is well-described, but the crosstalk with monocytes or macrophages and the nature of ligands/receptors implicated are just emerging. The macrophage-NK interaction is a major first-line defense against pathogens (bacteria, viruses, fungi, and parasites). The recruitment and the activation of NK cells to perform cytotoxicity or produce cytokines at the sites of inflammation are important to fight infections. The two main mechanisms by which macrophages can prime NK cells are (1) activation through soluble mediators such as IL-12, IL-18, and (2) stimulation through direct cell-to-cell contact. We will discuss the progress in matters of modulation of NK cell functions by monocytes and macrophages, in the steady state and during diseases.

No MeSH data available.


Related in: MedlinePlus