Limits...
RCAS1 expression in mobile tongue squamous cell carcinoma: an immunohistochemical study.

Theocharis S, Klijanienko J, Giaginis C, Rodriguez J, Jouffroy T, Girod A, Tsourouflis G, Sastre-Garau X - Med. Sci. Monit. (2011)

Bottom Line: The receptor-binding cancer antigen expressed on SiSo cells (RCAS1) is a human tumor-associated antigen that has been considered to play a crucial role in tumor progression by enabling cancer cells to evade immune surveillance.Enhanced RCAS1 expression was significantly associated with reduced depth of invasion (p=0.0069), low mitotic index (p=0.0251) and no evidence of muscular invasion (p=0.0098).RCAS1 expression was not associated with overall and disease-free survival.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Head and Neck Surgery, Institute Curie, Paris, France. theocharis@ath.forthnet.gr

ABSTRACT

Background: The receptor-binding cancer antigen expressed on SiSo cells (RCAS1) is a human tumor-associated antigen that has been considered to play a crucial role in tumor progression by enabling cancer cells to evade immune surveillance. The present study aimed to evaluate the clinical significance of RCAS1 expression in mobile tongue squamous cell carcinoma (SCC).

Material/methods: RCAS1 protein expression was assessed immunohistochemically on 49 mobile tongue SCC tissue samples obtained from an equal number of patients and was statistically analyzed with clinicopathological characteristics and overall and disease-free patients' survival.

Results: Enhanced RCAS1 expression was significantly associated with reduced depth of invasion (p=0.0069), low mitotic index (p=0.0251) and no evidence of muscular invasion (p=0.0098). A borderline association between RCAS1 expression and stromal inflammatory reaction was also noted (p=0.0660). RCAS1 expression was not associated with overall and disease-free survival.

Conclusions: Our data support evidence for possible implication of RCAS1 at the early stage of tumor progression in mobile tongue SCC, whereas the survival prediction using RCAS1 expression as a clinical marker seems uncertain for this type of malignancy.

Show MeSH

Related in: MedlinePlus

RCAS1 expression in (A) peripheral cell layers around keratin pearl (original magnification ×200) and (B) endothelial cells in the vicinity of tumor nests (original magnification ×400). Streptavidin-biotin-peroxidase, DAB chromogen, Harris hematoxylin counterstain.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3539616&req=5

f2-medscimonit-17-8-br228: RCAS1 expression in (A) peripheral cell layers around keratin pearl (original magnification ×200) and (B) endothelial cells in the vicinity of tumor nests (original magnification ×400). Streptavidin-biotin-peroxidase, DAB chromogen, Harris hematoxylin counterstain.

Mentions: RCAS1 positivity was noted in all of the mobile tongue SCC cases examined (49/49, 100%). The pattern of RCAS1 distribution was both cytoplasmic and membraneous (Figure 1). RCAS1 immunoreactivity was more frequently detected in the peripheral cell layers around keratin pearl where the tumor cells were less differentiated, whereas the cell layers inside the keratin pearl where the tumor cells were more differentiated and keratinized did not show positive RCAS1 immunoreactivity (Figure 2A). Weak RCAS1 immunoreactivity was also occasionally detected in endothelial cells in the vicinity of tumor nests (Figure 2B). Tongue epithelium with normal appearance adjacent to tumor was found negative for RCAS1.


RCAS1 expression in mobile tongue squamous cell carcinoma: an immunohistochemical study.

Theocharis S, Klijanienko J, Giaginis C, Rodriguez J, Jouffroy T, Girod A, Tsourouflis G, Sastre-Garau X - Med. Sci. Monit. (2011)

RCAS1 expression in (A) peripheral cell layers around keratin pearl (original magnification ×200) and (B) endothelial cells in the vicinity of tumor nests (original magnification ×400). Streptavidin-biotin-peroxidase, DAB chromogen, Harris hematoxylin counterstain.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3539616&req=5

f2-medscimonit-17-8-br228: RCAS1 expression in (A) peripheral cell layers around keratin pearl (original magnification ×200) and (B) endothelial cells in the vicinity of tumor nests (original magnification ×400). Streptavidin-biotin-peroxidase, DAB chromogen, Harris hematoxylin counterstain.
Mentions: RCAS1 positivity was noted in all of the mobile tongue SCC cases examined (49/49, 100%). The pattern of RCAS1 distribution was both cytoplasmic and membraneous (Figure 1). RCAS1 immunoreactivity was more frequently detected in the peripheral cell layers around keratin pearl where the tumor cells were less differentiated, whereas the cell layers inside the keratin pearl where the tumor cells were more differentiated and keratinized did not show positive RCAS1 immunoreactivity (Figure 2A). Weak RCAS1 immunoreactivity was also occasionally detected in endothelial cells in the vicinity of tumor nests (Figure 2B). Tongue epithelium with normal appearance adjacent to tumor was found negative for RCAS1.

Bottom Line: The receptor-binding cancer antigen expressed on SiSo cells (RCAS1) is a human tumor-associated antigen that has been considered to play a crucial role in tumor progression by enabling cancer cells to evade immune surveillance.Enhanced RCAS1 expression was significantly associated with reduced depth of invasion (p=0.0069), low mitotic index (p=0.0251) and no evidence of muscular invasion (p=0.0098).RCAS1 expression was not associated with overall and disease-free survival.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Head and Neck Surgery, Institute Curie, Paris, France. theocharis@ath.forthnet.gr

ABSTRACT

Background: The receptor-binding cancer antigen expressed on SiSo cells (RCAS1) is a human tumor-associated antigen that has been considered to play a crucial role in tumor progression by enabling cancer cells to evade immune surveillance. The present study aimed to evaluate the clinical significance of RCAS1 expression in mobile tongue squamous cell carcinoma (SCC).

Material/methods: RCAS1 protein expression was assessed immunohistochemically on 49 mobile tongue SCC tissue samples obtained from an equal number of patients and was statistically analyzed with clinicopathological characteristics and overall and disease-free patients' survival.

Results: Enhanced RCAS1 expression was significantly associated with reduced depth of invasion (p=0.0069), low mitotic index (p=0.0251) and no evidence of muscular invasion (p=0.0098). A borderline association between RCAS1 expression and stromal inflammatory reaction was also noted (p=0.0660). RCAS1 expression was not associated with overall and disease-free survival.

Conclusions: Our data support evidence for possible implication of RCAS1 at the early stage of tumor progression in mobile tongue SCC, whereas the survival prediction using RCAS1 expression as a clinical marker seems uncertain for this type of malignancy.

Show MeSH
Related in: MedlinePlus