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Review of therapeutic strategies for osteosarcoma, chondrosarcoma, and Ewing's sarcoma.

Dai X, Ma W, He X, Jha RK - Med. Sci. Monit. (2011)

Bottom Line: The most prevalent forms of bone cancer are osteosarcoma, chondrosarcoma, and Ewing's sarcoma.Although chemotherapy and radiotherapy have replaced traditional surgical treatments, survival rates have undergone only marginal improvements.Current knowledge of the molecular pathways involved in each type of cancer has led to better approaches in cancer treatment.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopedic Surgery, 1st Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

ABSTRACT
The most prevalent forms of bone cancer are osteosarcoma, chondrosarcoma, and Ewing's sarcoma. Although chemotherapy and radiotherapy have replaced traditional surgical treatments, survival rates have undergone only marginal improvements. Current knowledge of the molecular pathways involved in each type of cancer has led to better approaches in cancer treatment. A number of cell signaling molecules are involved in tumorigenesis, and specific targets have been identified based on these signal transducers. This review highlights some of the important cellular pathways and potential therapeutic targets, tumor site-specific irradiation techniques, and novel drug delivery systems used to administer these drugs.

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Related in: MedlinePlus

The causative agents contributing to the pathogenesis of osteosarcoma by altering the genetic make-up include the mutations in p53 and Rb tumor suppressor pathways, teenage growth spurt, Paget’s disease, chemical agents such as beryllium, radiations, and viruses such as Finkel-Biskis-Jinkins (FBJ) containing the src oncogene.
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getmorefigures.php?uid=PMC3539609&req=5

f1-medscimonit-17-8-ra177: The causative agents contributing to the pathogenesis of osteosarcoma by altering the genetic make-up include the mutations in p53 and Rb tumor suppressor pathways, teenage growth spurt, Paget’s disease, chemical agents such as beryllium, radiations, and viruses such as Finkel-Biskis-Jinkins (FBJ) containing the src oncogene.

Mentions: Fuchs and Pritchard [7] have suggested that certain agents contribute to the pathogenesis of osteosarcoma by altering the genetic make-up. These include radiation, chemical agents like beryllium, and viruses such as Finkel-Biskis-Jinkins (FBJ) virus containing the src oncogene. Figure 1 depicts the various causes of osteosarcoma.


Review of therapeutic strategies for osteosarcoma, chondrosarcoma, and Ewing's sarcoma.

Dai X, Ma W, He X, Jha RK - Med. Sci. Monit. (2011)

The causative agents contributing to the pathogenesis of osteosarcoma by altering the genetic make-up include the mutations in p53 and Rb tumor suppressor pathways, teenage growth spurt, Paget’s disease, chemical agents such as beryllium, radiations, and viruses such as Finkel-Biskis-Jinkins (FBJ) containing the src oncogene.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3539609&req=5

f1-medscimonit-17-8-ra177: The causative agents contributing to the pathogenesis of osteosarcoma by altering the genetic make-up include the mutations in p53 and Rb tumor suppressor pathways, teenage growth spurt, Paget’s disease, chemical agents such as beryllium, radiations, and viruses such as Finkel-Biskis-Jinkins (FBJ) containing the src oncogene.
Mentions: Fuchs and Pritchard [7] have suggested that certain agents contribute to the pathogenesis of osteosarcoma by altering the genetic make-up. These include radiation, chemical agents like beryllium, and viruses such as Finkel-Biskis-Jinkins (FBJ) virus containing the src oncogene. Figure 1 depicts the various causes of osteosarcoma.

Bottom Line: The most prevalent forms of bone cancer are osteosarcoma, chondrosarcoma, and Ewing's sarcoma.Although chemotherapy and radiotherapy have replaced traditional surgical treatments, survival rates have undergone only marginal improvements.Current knowledge of the molecular pathways involved in each type of cancer has led to better approaches in cancer treatment.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopedic Surgery, 1st Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

ABSTRACT
The most prevalent forms of bone cancer are osteosarcoma, chondrosarcoma, and Ewing's sarcoma. Although chemotherapy and radiotherapy have replaced traditional surgical treatments, survival rates have undergone only marginal improvements. Current knowledge of the molecular pathways involved in each type of cancer has led to better approaches in cancer treatment. A number of cell signaling molecules are involved in tumorigenesis, and specific targets have been identified based on these signal transducers. This review highlights some of the important cellular pathways and potential therapeutic targets, tumor site-specific irradiation techniques, and novel drug delivery systems used to administer these drugs.

Show MeSH
Related in: MedlinePlus