Limits...
Metastatic insulinoma - prolonged survival after multimodal approach.

Hagel AF, Hagel WH, Lindner AS, Kammerer FJ, Neurath MF, Konturek PC, Harsch IA - Med. Sci. Monit. (2011)

Bottom Line: To reachieve an asymptomatic state and further reduction in tumor mass, the decision was made for transarterial chemoembolization with streptozotocine.We regard this as the result of a multimodal approach and the extensive use of local tumor therapy.The different therapeutic options for local tumor therapy are reported and discussed.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine 1, University of Erlangen-Nuremberg, Erlangen, Germany. Alexander.Hagel@uk-erlangen.de

ABSTRACT

Background: Metastatic insulinoma is a disease associated with a poor life expectancy.

Case report: The case of a presently 68 year old female with malignant, metastatic insulinoma is reported. Due to severe clinical symptoms surgical tumor mass reduction was conducted. Furthermore the patient underwent a chemotherapy using streptozotocine and fluorouracil. After two years without any symptoms, the remaining hepatic metastases increased in size and again hypoglycemias occurred. To reachieve an asymptomatic state and further reduction in tumor mass, the decision was made for transarterial chemoembolization with streptozotocine. After the first treatment the patient was hypoglycemia - free for 3 months, after another more extensive chemoembolization the patient is presently symptom free for 8 months.

Conclusions: Since the diagnosis of extended disease was established, the patient has survived for 36 months. We regard this as the result of a multimodal approach and the extensive use of local tumor therapy. The different therapeutic options for local tumor therapy are reported and discussed.

Show MeSH

Related in: MedlinePlus

Abdominal MRI: Pancreatic tumor, invading the spleen, hepatic metastases.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3539604&req=5

f1-medscimonit-17-8-cs103: Abdominal MRI: Pancreatic tumor, invading the spleen, hepatic metastases.

Mentions: In magnetic resonance imaging and in ultrasonography several intrahepatic lesions were localized. Furthermore, a tumor in the pancreatic tail infiltrating the spleen could be detected. (Figure 1) Metastases were furthermore found in the lumbar spine and in the lower lobe of the right lung.


Metastatic insulinoma - prolonged survival after multimodal approach.

Hagel AF, Hagel WH, Lindner AS, Kammerer FJ, Neurath MF, Konturek PC, Harsch IA - Med. Sci. Monit. (2011)

Abdominal MRI: Pancreatic tumor, invading the spleen, hepatic metastases.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3539604&req=5

f1-medscimonit-17-8-cs103: Abdominal MRI: Pancreatic tumor, invading the spleen, hepatic metastases.
Mentions: In magnetic resonance imaging and in ultrasonography several intrahepatic lesions were localized. Furthermore, a tumor in the pancreatic tail infiltrating the spleen could be detected. (Figure 1) Metastases were furthermore found in the lumbar spine and in the lower lobe of the right lung.

Bottom Line: To reachieve an asymptomatic state and further reduction in tumor mass, the decision was made for transarterial chemoembolization with streptozotocine.We regard this as the result of a multimodal approach and the extensive use of local tumor therapy.The different therapeutic options for local tumor therapy are reported and discussed.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine 1, University of Erlangen-Nuremberg, Erlangen, Germany. Alexander.Hagel@uk-erlangen.de

ABSTRACT

Background: Metastatic insulinoma is a disease associated with a poor life expectancy.

Case report: The case of a presently 68 year old female with malignant, metastatic insulinoma is reported. Due to severe clinical symptoms surgical tumor mass reduction was conducted. Furthermore the patient underwent a chemotherapy using streptozotocine and fluorouracil. After two years without any symptoms, the remaining hepatic metastases increased in size and again hypoglycemias occurred. To reachieve an asymptomatic state and further reduction in tumor mass, the decision was made for transarterial chemoembolization with streptozotocine. After the first treatment the patient was hypoglycemia - free for 3 months, after another more extensive chemoembolization the patient is presently symptom free for 8 months.

Conclusions: Since the diagnosis of extended disease was established, the patient has survived for 36 months. We regard this as the result of a multimodal approach and the extensive use of local tumor therapy. The different therapeutic options for local tumor therapy are reported and discussed.

Show MeSH
Related in: MedlinePlus