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The inhibitory effect of Zingiber corallinum Hance essential oil on drug-resistant bacteria and evaluation of its acute toxicity.

Yang C, Zhou LL, Wang HY, Huang SN, Liu Q, Hu SL, Li TR, Chen YB, Jiang JX - Med. Sci. Monit. (2011)

Bottom Line: The ZCHO containing 79% terpinen-4-ol revealed better bacteriostatic effect than ZCHO with 34% terpinen-4-ol.ZCHO has obvious bacteriostasis and bactericidal effects, especially against drug-resistant Acinetobacter baumannii.Therefore, ZCHO is a promising natural bioactive component with antibacterial effect and satisfactory safety due to its low toxicity.

View Article: PubMed Central - PubMed

Affiliation: State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, 3rd Military Medical University, Changjiang Zhilu, Daping, Chongqing, P. R. China.

ABSTRACT

Background: The excessive and irregular use of antibiotics could result in the generation and diffusion of drug-resistant bacteria. The aim of this study was to investigate the inhibitory effect of Zingiber corallinum Hance essential oil (ZCHO) on drug-resistant bacteria, especially on drug-resistant Acinetobacter baumannii.

Material/methods: Susceptibility testing was used to evaluate the effect of ZCHO on growth inhibition of drug-resistant bacteria by paper disk method. Mice orally administered with ZCHO were used to observe acute toxicity and to determine median lethal dose (LD₅₀) of ZCHO. Broth dilution method was used to determine minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of ZCHO on drug-resistant Acinetobacter baumannii.

Results: ZCHO exhibited an obvious inhibitory effect not only on gram-negative drug-resistant bacteria including Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae and Acinetobacter baumannii, but also on gram-positive drug-resistant bacteria including Staphylococcus aureus, Staphylococcus epidermidis and Staphylococcus haemolyticus. The ZCHO containing 79% terpinen-4-ol revealed better bacteriostatic effect than ZCHO with 34% terpinen-4-ol. The LD₅₀ of ZCHO was 1790.427 mg/kg. The MIC and MBC of ZCHO on drug-resistant Acinetobacter baumannii were 1457.81 mg/L.

Conclusions: ZCHO has obvious bacteriostasis and bactericidal effects, especially against drug-resistant Acinetobacter baumannii. Therefore, ZCHO is a promising natural bioactive component with antibacterial effect and satisfactory safety due to its low toxicity.

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Related in: MedlinePlus

Zingiber corallinum Hance.
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f1-medscimonit-17-5-br139: Zingiber corallinum Hance.

Mentions: Zingiber corallinum Hance, also referred to as Yin Jiang or Jab bangx hnaib diel, is a Chinese herbal plant in the ginger family and ginger group (Figure 1). It has anti-inflammatory, detoxifying and anti-bacterial functions [5,6]. As a traditional perennial herb native to Yunnan, Guangxi, Guangdong and Guizhou areas, Zingiber corallinum Hance has been used for catarrhal rhinitis, cough, lumbago and diarrhea with satisfactory therapeutic effects [7]. The bioactive components in Zingiber corallinum Hance are aetherolea and coral ginger essential oil, and Zingiber corallinum Hance essential oil (ZCHO) that has obvious antibacterial activity [8,9]. Through supercritical carbon dioxide extraction, the essential oil was isolated from Zingiber corallinum Hance and identified by gas chromatography-mass spectroscopy [10]. The major bioactive components among 60 compounds that were identified are terpinen-4-ol, sabinene, β-bisabolene and γ-terpinene. ZCHO has attracted extensive attention due to its antibiosis property. Previous reports described its inhibitory effect on fungi and some non-drug-resistant pathogenic bacteria [11]; however, there have been few reports on its role in controlling drug-resistant pathogenic bacteria.


The inhibitory effect of Zingiber corallinum Hance essential oil on drug-resistant bacteria and evaluation of its acute toxicity.

Yang C, Zhou LL, Wang HY, Huang SN, Liu Q, Hu SL, Li TR, Chen YB, Jiang JX - Med. Sci. Monit. (2011)

Zingiber corallinum Hance.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3539599&req=5

f1-medscimonit-17-5-br139: Zingiber corallinum Hance.
Mentions: Zingiber corallinum Hance, also referred to as Yin Jiang or Jab bangx hnaib diel, is a Chinese herbal plant in the ginger family and ginger group (Figure 1). It has anti-inflammatory, detoxifying and anti-bacterial functions [5,6]. As a traditional perennial herb native to Yunnan, Guangxi, Guangdong and Guizhou areas, Zingiber corallinum Hance has been used for catarrhal rhinitis, cough, lumbago and diarrhea with satisfactory therapeutic effects [7]. The bioactive components in Zingiber corallinum Hance are aetherolea and coral ginger essential oil, and Zingiber corallinum Hance essential oil (ZCHO) that has obvious antibacterial activity [8,9]. Through supercritical carbon dioxide extraction, the essential oil was isolated from Zingiber corallinum Hance and identified by gas chromatography-mass spectroscopy [10]. The major bioactive components among 60 compounds that were identified are terpinen-4-ol, sabinene, β-bisabolene and γ-terpinene. ZCHO has attracted extensive attention due to its antibiosis property. Previous reports described its inhibitory effect on fungi and some non-drug-resistant pathogenic bacteria [11]; however, there have been few reports on its role in controlling drug-resistant pathogenic bacteria.

Bottom Line: The ZCHO containing 79% terpinen-4-ol revealed better bacteriostatic effect than ZCHO with 34% terpinen-4-ol.ZCHO has obvious bacteriostasis and bactericidal effects, especially against drug-resistant Acinetobacter baumannii.Therefore, ZCHO is a promising natural bioactive component with antibacterial effect and satisfactory safety due to its low toxicity.

View Article: PubMed Central - PubMed

Affiliation: State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, 3rd Military Medical University, Changjiang Zhilu, Daping, Chongqing, P. R. China.

ABSTRACT

Background: The excessive and irregular use of antibiotics could result in the generation and diffusion of drug-resistant bacteria. The aim of this study was to investigate the inhibitory effect of Zingiber corallinum Hance essential oil (ZCHO) on drug-resistant bacteria, especially on drug-resistant Acinetobacter baumannii.

Material/methods: Susceptibility testing was used to evaluate the effect of ZCHO on growth inhibition of drug-resistant bacteria by paper disk method. Mice orally administered with ZCHO were used to observe acute toxicity and to determine median lethal dose (LD₅₀) of ZCHO. Broth dilution method was used to determine minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of ZCHO on drug-resistant Acinetobacter baumannii.

Results: ZCHO exhibited an obvious inhibitory effect not only on gram-negative drug-resistant bacteria including Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae and Acinetobacter baumannii, but also on gram-positive drug-resistant bacteria including Staphylococcus aureus, Staphylococcus epidermidis and Staphylococcus haemolyticus. The ZCHO containing 79% terpinen-4-ol revealed better bacteriostatic effect than ZCHO with 34% terpinen-4-ol. The LD₅₀ of ZCHO was 1790.427 mg/kg. The MIC and MBC of ZCHO on drug-resistant Acinetobacter baumannii were 1457.81 mg/L.

Conclusions: ZCHO has obvious bacteriostasis and bactericidal effects, especially against drug-resistant Acinetobacter baumannii. Therefore, ZCHO is a promising natural bioactive component with antibacterial effect and satisfactory safety due to its low toxicity.

Show MeSH
Related in: MedlinePlus