Limits...
Impaired fetal adrenal function in intrahepatic cholestasis of pregnancy.

Wang C, Chen X, Zhou SF, Li X - Med. Sci. Monit. (2011)

Bottom Line: In women with ICP, the fetal serum cortisol and DHEAS levels were significantly higher than those in women with normal pregnancy, after correcting the impact of gestational age at delivery.The relationship between fetal cortisol and maternal cholic acid levels was bidirectional; the fetal cortisol tended to increase in mild ICP, while it decreased in severe ICP.In pregnant rats with estrogen-induced cholestasis, the fetal cortisol level was significantly lower in the group with oxytocin injection, compared with the group without oxytocin injection (191.92±18.86 vs. 272.71±31.83 ng/ml, P<0.05).

View Article: PubMed Central - PubMed

Affiliation: Department of Maternal and Fetal Medicine, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China.

ABSTRACT

Background: Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-associated liver disease of unknown etiology. The aim of this study was to investigate the change in maternal and fetal adrenal function in clinical and experimental ICP.

Material/methods: The maternal and fetal serum levels of cortisol and dehydroepiandrosterone sulfate (DHEAS) were determined in 14 women with ICP and in pregnant rats with estrogen-induced intrahepatic cholestasis.

Results: In women with ICP, the fetal serum cortisol and DHEAS levels were significantly higher than those in women with normal pregnancy, after correcting the impact of gestational age at delivery. The relationship between fetal cortisol and maternal cholic acid levels was bidirectional; the fetal cortisol tended to increase in mild ICP, while it decreased in severe ICP. In pregnant rats with estrogen-induced cholestasis, the fetal cortisol level was significantly lower in the group with oxytocin injection, compared with the group without oxytocin injection (191.92±18.86 vs. 272.71±31.83 ng/ml, P<0.05). In contrast, the fetal cortisol concentration was increased after oxytocin injection in normal control rats.

Conclusions: The data indicate that fetal stress-responsive system is stimulated in mild ICP, but it is suppressed in severe ICP, which might contribute to the occurrence of unpredictable sudden fetal death. Further studies are warranted to explore the role of impaired fetal adrenal function in the pathogenesis of ICP and the clinical implications.

Show MeSH

Related in: MedlinePlus

The maternal and fetal cortisol and DHEAS levels in ICP and normal pregnant rats with or without oxytocin injection. DHEAS, dehydroepiandrosterone sulfate; * P<0.05, ICP+ vs. ICP−; # P<0.05 Oxy− vs. Oxy+. ICP+, rats with ICP; ICP−, rats with normal pregnancy as control. Oxy+, rats with oxytocin injection, Oxy−, rats without oxytocin injection as control.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3539589&req=5

f2-medscimonit-17-5-cr265: The maternal and fetal cortisol and DHEAS levels in ICP and normal pregnant rats with or without oxytocin injection. DHEAS, dehydroepiandrosterone sulfate; * P<0.05, ICP+ vs. ICP−; # P<0.05 Oxy− vs. Oxy+. ICP+, rats with ICP; ICP−, rats with normal pregnancy as control. Oxy+, rats with oxytocin injection, Oxy−, rats without oxytocin injection as control.

Mentions: Figure 2 showed maternal and fetal DHEAS and cortisol levels in ICP and normal pregnant rats with and without injection of oxytocin. Except for that the fetal serum cortisol levels in the ICP+/Oxy+ group was significantly lower than in the ICP+/Oxy− group (191.92±18.86 vs. 272.71±31.83 ng/ml, P<0.05) in rats with ICP, the concentrations of maternal, maternal and fetal DHEAS and cortisol trended to increase in the groups with oxytocin injection in both ICP and normal rats, compared with corresponding groups without oxytocin injection, although the differences were insignificant. In rats injected with oxytocin, maternal and fetal DHEAS levels in ICP groups were significantly higher than in normal groups (P<0.05), while the levels of maternal and fetal cortisol in ICP groups were significantly lower (P<0.05). In rats without injection of oxytocin, the differences in maternal and fetal DHEAS and cortisol were insignificant between the ICP and control groups.


Impaired fetal adrenal function in intrahepatic cholestasis of pregnancy.

Wang C, Chen X, Zhou SF, Li X - Med. Sci. Monit. (2011)

The maternal and fetal cortisol and DHEAS levels in ICP and normal pregnant rats with or without oxytocin injection. DHEAS, dehydroepiandrosterone sulfate; * P<0.05, ICP+ vs. ICP−; # P<0.05 Oxy− vs. Oxy+. ICP+, rats with ICP; ICP−, rats with normal pregnancy as control. Oxy+, rats with oxytocin injection, Oxy−, rats without oxytocin injection as control.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3539589&req=5

f2-medscimonit-17-5-cr265: The maternal and fetal cortisol and DHEAS levels in ICP and normal pregnant rats with or without oxytocin injection. DHEAS, dehydroepiandrosterone sulfate; * P<0.05, ICP+ vs. ICP−; # P<0.05 Oxy− vs. Oxy+. ICP+, rats with ICP; ICP−, rats with normal pregnancy as control. Oxy+, rats with oxytocin injection, Oxy−, rats without oxytocin injection as control.
Mentions: Figure 2 showed maternal and fetal DHEAS and cortisol levels in ICP and normal pregnant rats with and without injection of oxytocin. Except for that the fetal serum cortisol levels in the ICP+/Oxy+ group was significantly lower than in the ICP+/Oxy− group (191.92±18.86 vs. 272.71±31.83 ng/ml, P<0.05) in rats with ICP, the concentrations of maternal, maternal and fetal DHEAS and cortisol trended to increase in the groups with oxytocin injection in both ICP and normal rats, compared with corresponding groups without oxytocin injection, although the differences were insignificant. In rats injected with oxytocin, maternal and fetal DHEAS levels in ICP groups were significantly higher than in normal groups (P<0.05), while the levels of maternal and fetal cortisol in ICP groups were significantly lower (P<0.05). In rats without injection of oxytocin, the differences in maternal and fetal DHEAS and cortisol were insignificant between the ICP and control groups.

Bottom Line: In women with ICP, the fetal serum cortisol and DHEAS levels were significantly higher than those in women with normal pregnancy, after correcting the impact of gestational age at delivery.The relationship between fetal cortisol and maternal cholic acid levels was bidirectional; the fetal cortisol tended to increase in mild ICP, while it decreased in severe ICP.In pregnant rats with estrogen-induced cholestasis, the fetal cortisol level was significantly lower in the group with oxytocin injection, compared with the group without oxytocin injection (191.92±18.86 vs. 272.71±31.83 ng/ml, P<0.05).

View Article: PubMed Central - PubMed

Affiliation: Department of Maternal and Fetal Medicine, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China.

ABSTRACT

Background: Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-associated liver disease of unknown etiology. The aim of this study was to investigate the change in maternal and fetal adrenal function in clinical and experimental ICP.

Material/methods: The maternal and fetal serum levels of cortisol and dehydroepiandrosterone sulfate (DHEAS) were determined in 14 women with ICP and in pregnant rats with estrogen-induced intrahepatic cholestasis.

Results: In women with ICP, the fetal serum cortisol and DHEAS levels were significantly higher than those in women with normal pregnancy, after correcting the impact of gestational age at delivery. The relationship between fetal cortisol and maternal cholic acid levels was bidirectional; the fetal cortisol tended to increase in mild ICP, while it decreased in severe ICP. In pregnant rats with estrogen-induced cholestasis, the fetal cortisol level was significantly lower in the group with oxytocin injection, compared with the group without oxytocin injection (191.92±18.86 vs. 272.71±31.83 ng/ml, P<0.05). In contrast, the fetal cortisol concentration was increased after oxytocin injection in normal control rats.

Conclusions: The data indicate that fetal stress-responsive system is stimulated in mild ICP, but it is suppressed in severe ICP, which might contribute to the occurrence of unpredictable sudden fetal death. Further studies are warranted to explore the role of impaired fetal adrenal function in the pathogenesis of ICP and the clinical implications.

Show MeSH
Related in: MedlinePlus