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Gastric pH and motility in a porcine model of acute lung injury using a wireless motility capsule.

Rauch S, Muellenbach RM, Johannes A, Zollhöfer B, Roewer N - Med. Sci. Monit. (2011)

Bottom Line: Gastric pH values were statistically significantly different (P<0.003) in the animals over time and ranged from 1.15 to 9.94 [5.73 ± 0.47 (mean ± SD)] with an interquartile range of 0.11 to 2.07.The capsule pressure recordings ranged from 2 to 4 mmHg [2.6 ± 0.5 mmHg (mean ± SD)].There was no change in pressure patterns or sudden rise of pH >3 pH units during 24 hours.

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesiology, University of Wurzburg, Wurzburg, Germany. rauch_s@klinik.uni-wuerzburg.de

ABSTRACT

Background: Evaluation of gastric pH and motility in a porcine model of acute lung injury using a novel, wireless motility capsule.

Material/methods: A motility capsule was applied into the stomach of 7 Pietrain pigs with acute lung injury induced by high volume saline lavage. Wireless transmission of pH, pressure and temperature data was performed by a recorder attached to the animal's abdomen. Gastric motility was evaluated using pH and pressure values, and capsule location was confirmed by autopsy.

Results: Gastric pH values were statistically significantly different (P<0.003) in the animals over time and ranged from 1.15 to 9.94 [5.73 ± 0.47 (mean ± SD)] with an interquartile range of 0.11 to 2.07. The capsule pressure recordings ranged from 2 to 4 mmHg [2.6 ± 0.5 mmHg (mean ± SD)]. There was no change in pressure patterns or sudden rise of pH >3 pH units during 24 hours. All animals had a gastroparesis with the capsules located in the stomach as indicated by the pressure and pH data and confirmed by necropsy.

Conclusions: The preliminary data show that Pietrain pigs with acute lung injury have a high variability in gastric pH and severely disturbed gastric motility.

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Related in: MedlinePlus

SmartPill® GI Monitoring Capsule.
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f1-medscimonit-17-7-br161: SmartPill® GI Monitoring Capsule.

Mentions: Critically ill patients who are sedated and mechanically ventilated are likely to have gastrointestinal complications and motility disturbances [1–3]. Many methods used to determine gastric motility in the critical care setting are unreliable or impractical [4]. A newly developed motility capsule (Figure 1) for assessing gastric emptying in patients with suspected gastroparesis has been available since 2006 [5,6]. It is a wireless capsule that transmits pH, pressure, and temperature to a data recorder. This system detects gastric emptying by recording the abrupt rise of pH by more than 3 units that normally accompanies transition of the capsule into the duodenum with its pH of near 6.


Gastric pH and motility in a porcine model of acute lung injury using a wireless motility capsule.

Rauch S, Muellenbach RM, Johannes A, Zollhöfer B, Roewer N - Med. Sci. Monit. (2011)

SmartPill® GI Monitoring Capsule.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3539567&req=5

f1-medscimonit-17-7-br161: SmartPill® GI Monitoring Capsule.
Mentions: Critically ill patients who are sedated and mechanically ventilated are likely to have gastrointestinal complications and motility disturbances [1–3]. Many methods used to determine gastric motility in the critical care setting are unreliable or impractical [4]. A newly developed motility capsule (Figure 1) for assessing gastric emptying in patients with suspected gastroparesis has been available since 2006 [5,6]. It is a wireless capsule that transmits pH, pressure, and temperature to a data recorder. This system detects gastric emptying by recording the abrupt rise of pH by more than 3 units that normally accompanies transition of the capsule into the duodenum with its pH of near 6.

Bottom Line: Gastric pH values were statistically significantly different (P<0.003) in the animals over time and ranged from 1.15 to 9.94 [5.73 ± 0.47 (mean ± SD)] with an interquartile range of 0.11 to 2.07.The capsule pressure recordings ranged from 2 to 4 mmHg [2.6 ± 0.5 mmHg (mean ± SD)].There was no change in pressure patterns or sudden rise of pH >3 pH units during 24 hours.

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesiology, University of Wurzburg, Wurzburg, Germany. rauch_s@klinik.uni-wuerzburg.de

ABSTRACT

Background: Evaluation of gastric pH and motility in a porcine model of acute lung injury using a novel, wireless motility capsule.

Material/methods: A motility capsule was applied into the stomach of 7 Pietrain pigs with acute lung injury induced by high volume saline lavage. Wireless transmission of pH, pressure and temperature data was performed by a recorder attached to the animal's abdomen. Gastric motility was evaluated using pH and pressure values, and capsule location was confirmed by autopsy.

Results: Gastric pH values were statistically significantly different (P<0.003) in the animals over time and ranged from 1.15 to 9.94 [5.73 ± 0.47 (mean ± SD)] with an interquartile range of 0.11 to 2.07. The capsule pressure recordings ranged from 2 to 4 mmHg [2.6 ± 0.5 mmHg (mean ± SD)]. There was no change in pressure patterns or sudden rise of pH >3 pH units during 24 hours. All animals had a gastroparesis with the capsules located in the stomach as indicated by the pressure and pH data and confirmed by necropsy.

Conclusions: The preliminary data show that Pietrain pigs with acute lung injury have a high variability in gastric pH and severely disturbed gastric motility.

Show MeSH
Related in: MedlinePlus