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Association between Takayasu arteritis and ulcerative colitis - case report and review of serological HLA analysis.

Takahashi N, Tanabe K, Sugamori T, Sato M, Kitamura J, Sato H, Yoshitomi H, Ishibashi Y, Shimada T - Med. Sci. Monit. (2011)

Bottom Line: However, the coexistence of these 2 diseases has rarely been reported.We present a case report and review of the pertinent literature on serological analysis of HLA haplotype of the patients who exhibit both these diseases.The pathological relevance of HLA-A24, B52, and DR2 to concomitant Takayasu arteritis and ulcerative colitis requires further investigation.

View Article: PubMed Central - PubMed

Affiliation: 4th Department of Internal Medicine, Shimane University Faculty of Medicine, Izumo City, Shimane, Japan. yukihiro@med.shimane-u.ac.jp

ABSTRACT

Background: Takayasu arteritis and ulcerative colitis are immune-mediated inflammatory diseases; genetic factors are assumed to play an important role in the pathogenesis of these 2 diseases. However, the coexistence of these 2 diseases has rarely been reported.

Case report: In this report, we present a rare case of a 29-year-old man with a 4 years history of ulcerative colitis who developed Takayasu arteritis. He was found to carry the following human leukocyte antigens (HLA): A11, A24, B52, B62, DR4, and DR9.

Conclusions: We present a case report and review of the pertinent literature on serological analysis of HLA haplotype of the patients who exhibit both these diseases. In patients with both Takayasu arteritis and ulcerative colitis, high frequency of HLA-A24, B52, and DR 2 is observed. The pathological relevance of HLA-A24, B52, and DR2 to concomitant Takayasu arteritis and ulcerative colitis requires further investigation.

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Related in: MedlinePlus

Apical long-axis view of left ventricle in 2-dimensional transthoracic echocardiograpy, which demonstrates severe aortic valve regurgitation.
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Related In: Results  -  Collection


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f2-medscimonit-17-7-cs81: Apical long-axis view of left ventricle in 2-dimensional transthoracic echocardiograpy, which demonstrates severe aortic valve regurgitation.

Mentions: Transthoracic echocardiogram revealed severe aortic valve insufficiency (Figure 2) with mild left ventricular hypertrophy (left ventricular end-diastolic diameter: 52 mm, end-systolic diameter: 31 mm, left ventricular ejection fraction measured by using modified Simpson method: 68%, interventricular septum: 13 mm, posterior wall: 12 mm, Left ventricular mass index 152 g/m2). HLA typing revealed demonstrated the following antigens: A11, A24, B52, B62, DR4, and DR9.


Association between Takayasu arteritis and ulcerative colitis - case report and review of serological HLA analysis.

Takahashi N, Tanabe K, Sugamori T, Sato M, Kitamura J, Sato H, Yoshitomi H, Ishibashi Y, Shimada T - Med. Sci. Monit. (2011)

Apical long-axis view of left ventricle in 2-dimensional transthoracic echocardiograpy, which demonstrates severe aortic valve regurgitation.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3539562&req=5

f2-medscimonit-17-7-cs81: Apical long-axis view of left ventricle in 2-dimensional transthoracic echocardiograpy, which demonstrates severe aortic valve regurgitation.
Mentions: Transthoracic echocardiogram revealed severe aortic valve insufficiency (Figure 2) with mild left ventricular hypertrophy (left ventricular end-diastolic diameter: 52 mm, end-systolic diameter: 31 mm, left ventricular ejection fraction measured by using modified Simpson method: 68%, interventricular septum: 13 mm, posterior wall: 12 mm, Left ventricular mass index 152 g/m2). HLA typing revealed demonstrated the following antigens: A11, A24, B52, B62, DR4, and DR9.

Bottom Line: However, the coexistence of these 2 diseases has rarely been reported.We present a case report and review of the pertinent literature on serological analysis of HLA haplotype of the patients who exhibit both these diseases.The pathological relevance of HLA-A24, B52, and DR2 to concomitant Takayasu arteritis and ulcerative colitis requires further investigation.

View Article: PubMed Central - PubMed

Affiliation: 4th Department of Internal Medicine, Shimane University Faculty of Medicine, Izumo City, Shimane, Japan. yukihiro@med.shimane-u.ac.jp

ABSTRACT

Background: Takayasu arteritis and ulcerative colitis are immune-mediated inflammatory diseases; genetic factors are assumed to play an important role in the pathogenesis of these 2 diseases. However, the coexistence of these 2 diseases has rarely been reported.

Case report: In this report, we present a rare case of a 29-year-old man with a 4 years history of ulcerative colitis who developed Takayasu arteritis. He was found to carry the following human leukocyte antigens (HLA): A11, A24, B52, B62, DR4, and DR9.

Conclusions: We present a case report and review of the pertinent literature on serological analysis of HLA haplotype of the patients who exhibit both these diseases. In patients with both Takayasu arteritis and ulcerative colitis, high frequency of HLA-A24, B52, and DR 2 is observed. The pathological relevance of HLA-A24, B52, and DR2 to concomitant Takayasu arteritis and ulcerative colitis requires further investigation.

Show MeSH
Related in: MedlinePlus