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Association between Takayasu arteritis and ulcerative colitis - case report and review of serological HLA analysis.

Takahashi N, Tanabe K, Sugamori T, Sato M, Kitamura J, Sato H, Yoshitomi H, Ishibashi Y, Shimada T - Med. Sci. Monit. (2011)

Bottom Line: However, the coexistence of these 2 diseases has rarely been reported.We present a case report and review of the pertinent literature on serological analysis of HLA haplotype of the patients who exhibit both these diseases.The pathological relevance of HLA-A24, B52, and DR2 to concomitant Takayasu arteritis and ulcerative colitis requires further investigation.

View Article: PubMed Central - PubMed

Affiliation: 4th Department of Internal Medicine, Shimane University Faculty of Medicine, Izumo City, Shimane, Japan. yukihiro@med.shimane-u.ac.jp

ABSTRACT

Background: Takayasu arteritis and ulcerative colitis are immune-mediated inflammatory diseases; genetic factors are assumed to play an important role in the pathogenesis of these 2 diseases. However, the coexistence of these 2 diseases has rarely been reported.

Case report: In this report, we present a rare case of a 29-year-old man with a 4 years history of ulcerative colitis who developed Takayasu arteritis. He was found to carry the following human leukocyte antigens (HLA): A11, A24, B52, B62, DR4, and DR9.

Conclusions: We present a case report and review of the pertinent literature on serological analysis of HLA haplotype of the patients who exhibit both these diseases. In patients with both Takayasu arteritis and ulcerative colitis, high frequency of HLA-A24, B52, and DR 2 is observed. The pathological relevance of HLA-A24, B52, and DR2 to concomitant Takayasu arteritis and ulcerative colitis requires further investigation.

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Related in: MedlinePlus

3-dimensional reconstruction of the great arteries by computed tomography, which demonstrates the dilatation of the ascending aorta and stenosis of the left subclavian artery, descending aorta with severe calcification of arterial wall.
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Related In: Results  -  Collection


getmorefigures.php?uid=PMC3539562&req=5

f1-medscimonit-17-7-cs81: 3-dimensional reconstruction of the great arteries by computed tomography, which demonstrates the dilatation of the ascending aorta and stenosis of the left subclavian artery, descending aorta with severe calcification of arterial wall.

Mentions: Contrast-enhanced computed tomography and magnetic resonance angiography revealed dilatation of the ascending aorta and stenosis of the left subclavian artery, descending aorta, and superior mesenteric artery with severe calcification of arterial wall (Figure 1). Multidetector computed tomography showed almost normal epicardial coronary arteries.


Association between Takayasu arteritis and ulcerative colitis - case report and review of serological HLA analysis.

Takahashi N, Tanabe K, Sugamori T, Sato M, Kitamura J, Sato H, Yoshitomi H, Ishibashi Y, Shimada T - Med. Sci. Monit. (2011)

3-dimensional reconstruction of the great arteries by computed tomography, which demonstrates the dilatation of the ascending aorta and stenosis of the left subclavian artery, descending aorta with severe calcification of arterial wall.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3539562&req=5

f1-medscimonit-17-7-cs81: 3-dimensional reconstruction of the great arteries by computed tomography, which demonstrates the dilatation of the ascending aorta and stenosis of the left subclavian artery, descending aorta with severe calcification of arterial wall.
Mentions: Contrast-enhanced computed tomography and magnetic resonance angiography revealed dilatation of the ascending aorta and stenosis of the left subclavian artery, descending aorta, and superior mesenteric artery with severe calcification of arterial wall (Figure 1). Multidetector computed tomography showed almost normal epicardial coronary arteries.

Bottom Line: However, the coexistence of these 2 diseases has rarely been reported.We present a case report and review of the pertinent literature on serological analysis of HLA haplotype of the patients who exhibit both these diseases.The pathological relevance of HLA-A24, B52, and DR2 to concomitant Takayasu arteritis and ulcerative colitis requires further investigation.

View Article: PubMed Central - PubMed

Affiliation: 4th Department of Internal Medicine, Shimane University Faculty of Medicine, Izumo City, Shimane, Japan. yukihiro@med.shimane-u.ac.jp

ABSTRACT

Background: Takayasu arteritis and ulcerative colitis are immune-mediated inflammatory diseases; genetic factors are assumed to play an important role in the pathogenesis of these 2 diseases. However, the coexistence of these 2 diseases has rarely been reported.

Case report: In this report, we present a rare case of a 29-year-old man with a 4 years history of ulcerative colitis who developed Takayasu arteritis. He was found to carry the following human leukocyte antigens (HLA): A11, A24, B52, B62, DR4, and DR9.

Conclusions: We present a case report and review of the pertinent literature on serological analysis of HLA haplotype of the patients who exhibit both these diseases. In patients with both Takayasu arteritis and ulcerative colitis, high frequency of HLA-A24, B52, and DR 2 is observed. The pathological relevance of HLA-A24, B52, and DR2 to concomitant Takayasu arteritis and ulcerative colitis requires further investigation.

Show MeSH
Related in: MedlinePlus