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Measurement and comparison of skin dose using OneDose MOSFET and Mobile MOSFET for patients with acute lymphoblastic leukemia.

Mattar EH, Hammad LF, Al-Mohammed HI - Med. Sci. Monit. (2011)

Bottom Line: The results showed there was no variation between skin dose measured with OneDose MOSFET and Mobile MOSFET in all patients.Furthermore, the results showed for every anatomical site selected there was no significant difference in the dose delivered using either OneDose MOSFET detector or Mobile MOSFET as compared to the prescribed dose.The study concludes that One-Dose MOSFET detectors and Mobile MOSFET both give a direct read-out immediately after the treatment; therefore both detectors are suitable options when measuring skin dose for total body irradiation treatment.

View Article: PubMed Central - PubMed

Affiliation: Radiologic Sciences Department, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.

ABSTRACT

Background: Total body irradiation is a protocol used to treat acute lymphoblastic leukemia in patients prior to bone marrow transplant. It is involved in the treatment of the whole body using a large radiation field with extended source-skin distance. Therefore measuring and monitoring the skin dose during the treatment is important. Two kinds of metal oxide semiconductor field effect transistor (OneDose MOSFET and mobile MOSEFT) dosimeter are used during the treatment delivery to measure the skin dose to specific points and compare it with the target prescribed dose. The objective of this study was to compare the variation of skin dose in patients with acute lymphatic leukemia (ALL) treated with total body irradiation (TBI) using OneDose MOSFET detectors and Mobile MOSFET, and then compare both results with the target prescribed dose.

Material/methods: The measurements involved 32 patient's (16 males, 16 females), aged between 14-30 years, with an average age of 22.41 years. One-Dose MOSFET and Mobile MOSFET dosimetry were performed at 10 different anatomical sites on every patient.

Results: The results showed there was no variation between skin dose measured with OneDose MOSFET and Mobile MOSFET in all patients. Furthermore, the results showed for every anatomical site selected there was no significant difference in the dose delivered using either OneDose MOSFET detector or Mobile MOSFET as compared to the prescribed dose.

Conclusions: The study concludes that One-Dose MOSFET detectors and Mobile MOSFET both give a direct read-out immediately after the treatment; therefore both detectors are suitable options when measuring skin dose for total body irradiation treatment.

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Related in: MedlinePlus

Mobile MOSEFT system.
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f2-medscimonit-17-7-mt51: Mobile MOSEFT system.

Mentions: In contrast, the Mobile MOSFET system (TN-502RD MOSFET dosimeters, Thomson and Nielsen Electronics Ltd, Ottawa, Canada) (Figure 2), consists of 5 high-sensitivity dosimeters attached to a reader. The 5 supports on the MOSFETs probes permit measurements of 5 different locations [3,5]. The attached reader records a voltage difference in each of the dosimeters when exposed to radiation. The difference between the voltages is proportional to the total amount of radiation [3]. The Mobile MOSFET channels are used in the standard basic setting, giving a normal sensitivity of ~1 mV/cGy. The overall physical size of the sensors is 1.0×1.0×3.5 mm3, and the actual sensitive volume is 0.2×0.2 mm×0.5 μm. MOSFET calibrations were performed under full buildup conditions, which then produced a very small sensing volume and less than 2% isotropy under full build-up through 360 degrees rotation. A group of MOSFET detectors were exposed to 100 cGy dose using 6 MV from Varian Clinac 2300 EX accelerator at 10 cm water equivalent depth. Both MOSFETs detectors are characterized for energy response, [5,6]; however, the details of energy depend for MOSFET is out of the scope of the present study. All 5 channels of the mobile MOSFET are made for multiple uses and can accumulate a dose up to 7000 cGy before it needs to be replaced [7]. The system is controlled by remote dose-verification software running on a personal laptop. The present study aimed to compare the target prescribed dose to the dose that is the measured by OneDose MOSFET detector and Mobile MOSFET dosimetry in order to determine which system is superior in monitoring and measuring the TBI doses.


Measurement and comparison of skin dose using OneDose MOSFET and Mobile MOSFET for patients with acute lymphoblastic leukemia.

Mattar EH, Hammad LF, Al-Mohammed HI - Med. Sci. Monit. (2011)

Mobile MOSEFT system.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3539560&req=5

f2-medscimonit-17-7-mt51: Mobile MOSEFT system.
Mentions: In contrast, the Mobile MOSFET system (TN-502RD MOSFET dosimeters, Thomson and Nielsen Electronics Ltd, Ottawa, Canada) (Figure 2), consists of 5 high-sensitivity dosimeters attached to a reader. The 5 supports on the MOSFETs probes permit measurements of 5 different locations [3,5]. The attached reader records a voltage difference in each of the dosimeters when exposed to radiation. The difference between the voltages is proportional to the total amount of radiation [3]. The Mobile MOSFET channels are used in the standard basic setting, giving a normal sensitivity of ~1 mV/cGy. The overall physical size of the sensors is 1.0×1.0×3.5 mm3, and the actual sensitive volume is 0.2×0.2 mm×0.5 μm. MOSFET calibrations were performed under full buildup conditions, which then produced a very small sensing volume and less than 2% isotropy under full build-up through 360 degrees rotation. A group of MOSFET detectors were exposed to 100 cGy dose using 6 MV from Varian Clinac 2300 EX accelerator at 10 cm water equivalent depth. Both MOSFETs detectors are characterized for energy response, [5,6]; however, the details of energy depend for MOSFET is out of the scope of the present study. All 5 channels of the mobile MOSFET are made for multiple uses and can accumulate a dose up to 7000 cGy before it needs to be replaced [7]. The system is controlled by remote dose-verification software running on a personal laptop. The present study aimed to compare the target prescribed dose to the dose that is the measured by OneDose MOSFET detector and Mobile MOSFET dosimetry in order to determine which system is superior in monitoring and measuring the TBI doses.

Bottom Line: The results showed there was no variation between skin dose measured with OneDose MOSFET and Mobile MOSFET in all patients.Furthermore, the results showed for every anatomical site selected there was no significant difference in the dose delivered using either OneDose MOSFET detector or Mobile MOSFET as compared to the prescribed dose.The study concludes that One-Dose MOSFET detectors and Mobile MOSFET both give a direct read-out immediately after the treatment; therefore both detectors are suitable options when measuring skin dose for total body irradiation treatment.

View Article: PubMed Central - PubMed

Affiliation: Radiologic Sciences Department, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.

ABSTRACT

Background: Total body irradiation is a protocol used to treat acute lymphoblastic leukemia in patients prior to bone marrow transplant. It is involved in the treatment of the whole body using a large radiation field with extended source-skin distance. Therefore measuring and monitoring the skin dose during the treatment is important. Two kinds of metal oxide semiconductor field effect transistor (OneDose MOSFET and mobile MOSEFT) dosimeter are used during the treatment delivery to measure the skin dose to specific points and compare it with the target prescribed dose. The objective of this study was to compare the variation of skin dose in patients with acute lymphatic leukemia (ALL) treated with total body irradiation (TBI) using OneDose MOSFET detectors and Mobile MOSFET, and then compare both results with the target prescribed dose.

Material/methods: The measurements involved 32 patient's (16 males, 16 females), aged between 14-30 years, with an average age of 22.41 years. One-Dose MOSFET and Mobile MOSFET dosimetry were performed at 10 different anatomical sites on every patient.

Results: The results showed there was no variation between skin dose measured with OneDose MOSFET and Mobile MOSFET in all patients. Furthermore, the results showed for every anatomical site selected there was no significant difference in the dose delivered using either OneDose MOSFET detector or Mobile MOSFET as compared to the prescribed dose.

Conclusions: The study concludes that One-Dose MOSFET detectors and Mobile MOSFET both give a direct read-out immediately after the treatment; therefore both detectors are suitable options when measuring skin dose for total body irradiation treatment.

Show MeSH
Related in: MedlinePlus