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Predicting the adult height of girls with central precocious puberty.

Allali S, Lemaire P, Couto-Silva AC, Prété G, Trivin C, Brauner R - Med. Sci. Monit. (2011)

Bottom Line: Treated: the difference between AH and TH (-0.6±5.4 cm) was predicted by (using SDS) =3.68 (height at initial evaluation - TH) - 1.94 (height at initial evaluation-predicted AH) - 4.23; R2=0.73.Untreated: the difference between AH and TH (1.7±4.3 cm) was predicted by =2.76 (height at initial evaluation - TH) - 3.68 LH/FSH peaks ratio - 3.49; R2=0.77.A greater difference between height at initial evaluation and TH (SDS) is associated with a greater AH in treated and untreated girls, as are smaller differences between height at initial evaluation and predicted AH in treated and lower LH/FSH peaks ratios in untreated girls.

View Article: PubMed Central - PubMed

Affiliation: Université Paris Descartes and AP-HP, Hôpital Bicêtre, Unité d'Endocrinologie Pédiatrique, Paris, France.

ABSTRACT

Background: There are no absolute criteria for identifying those girls with idiopathic central precocious puberty (CPP) who will benefit from gonadotropin-releasing hormone analog (GnRHa) treatment. Our objective was to predict at initial evaluation the differences between adult height (AH) and target height (TH) and (for untreated girls) the time between puberty onset and first menstruation.

Material/methods: The 122 girls with CPP who reached their AH included 70 who were given GnRHa because their predicted AH was <155 cm (n=24), their luteinising hormone (LH)/follicle-stimulating hormone peaks (FSH) ratio was >0.66 (n=41) and/or their estradiol was >15 pg/ml (n=40). The other 52 were untreated because their predicted AH was >155 cm. Multiple linear regressions were performed on several subsets of variables.

Results: Treated: the difference between AH and TH (-0.6±5.4 cm) was predicted by (using SDS) =3.68 (height at initial evaluation - TH) - 1.94 (height at initial evaluation-predicted AH) - 4.23; R2=0.73. Untreated: the difference between AH and TH (1.7±4.3 cm) was predicted by =2.76 (height at initial evaluation - TH) - 3.68 LH/FSH peaks ratio - 3.49; R2=0.77. Time between puberty onset and first menstruation (years) was predicted by =12.2 - 1.06 age CPP - 0.4 (height at initial evaluation - TH); R2=0.75.

Conclusions: A greater difference between height at initial evaluation and TH (SDS) is associated with a greater AH in treated and untreated girls, as are smaller differences between height at initial evaluation and predicted AH in treated and lower LH/FSH peaks ratios in untreated girls.

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Predictions of the time (yr) between the onset of puberty and the first menstruation of girls with untreated CPP. TH: target height. Straight lines are contour plots, every year. Each point corresponds to the predicted time, with the actual time indicated. The point is changed to a cross when the actual time is more than one year less than the calculated one.
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f3-medscimonit-17-6-ph41: Predictions of the time (yr) between the onset of puberty and the first menstruation of girls with untreated CPP. TH: target height. Straight lines are contour plots, every year. Each point corresponds to the predicted time, with the actual time indicated. The point is changed to a cross when the actual time is more than one year less than the calculated one.

Mentions: The 52 girls included 39 who began menstruating before they were 11 years old (19/51 in their mothers). The time between the onset of puberty and first menstruation (years) can be calculated with the formula 12.2 – 1.06 age CPP − 0.4 (height at initial evaluation – TH, SDS) with R2=0.75 (Figure 3).


Predicting the adult height of girls with central precocious puberty.

Allali S, Lemaire P, Couto-Silva AC, Prété G, Trivin C, Brauner R - Med. Sci. Monit. (2011)

Predictions of the time (yr) between the onset of puberty and the first menstruation of girls with untreated CPP. TH: target height. Straight lines are contour plots, every year. Each point corresponds to the predicted time, with the actual time indicated. The point is changed to a cross when the actual time is more than one year less than the calculated one.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3539549&req=5

f3-medscimonit-17-6-ph41: Predictions of the time (yr) between the onset of puberty and the first menstruation of girls with untreated CPP. TH: target height. Straight lines are contour plots, every year. Each point corresponds to the predicted time, with the actual time indicated. The point is changed to a cross when the actual time is more than one year less than the calculated one.
Mentions: The 52 girls included 39 who began menstruating before they were 11 years old (19/51 in their mothers). The time between the onset of puberty and first menstruation (years) can be calculated with the formula 12.2 – 1.06 age CPP − 0.4 (height at initial evaluation – TH, SDS) with R2=0.75 (Figure 3).

Bottom Line: Treated: the difference between AH and TH (-0.6±5.4 cm) was predicted by (using SDS) =3.68 (height at initial evaluation - TH) - 1.94 (height at initial evaluation-predicted AH) - 4.23; R2=0.73.Untreated: the difference between AH and TH (1.7±4.3 cm) was predicted by =2.76 (height at initial evaluation - TH) - 3.68 LH/FSH peaks ratio - 3.49; R2=0.77.A greater difference between height at initial evaluation and TH (SDS) is associated with a greater AH in treated and untreated girls, as are smaller differences between height at initial evaluation and predicted AH in treated and lower LH/FSH peaks ratios in untreated girls.

View Article: PubMed Central - PubMed

Affiliation: Université Paris Descartes and AP-HP, Hôpital Bicêtre, Unité d'Endocrinologie Pédiatrique, Paris, France.

ABSTRACT

Background: There are no absolute criteria for identifying those girls with idiopathic central precocious puberty (CPP) who will benefit from gonadotropin-releasing hormone analog (GnRHa) treatment. Our objective was to predict at initial evaluation the differences between adult height (AH) and target height (TH) and (for untreated girls) the time between puberty onset and first menstruation.

Material/methods: The 122 girls with CPP who reached their AH included 70 who were given GnRHa because their predicted AH was <155 cm (n=24), their luteinising hormone (LH)/follicle-stimulating hormone peaks (FSH) ratio was >0.66 (n=41) and/or their estradiol was >15 pg/ml (n=40). The other 52 were untreated because their predicted AH was >155 cm. Multiple linear regressions were performed on several subsets of variables.

Results: Treated: the difference between AH and TH (-0.6±5.4 cm) was predicted by (using SDS) =3.68 (height at initial evaluation - TH) - 1.94 (height at initial evaluation-predicted AH) - 4.23; R2=0.73. Untreated: the difference between AH and TH (1.7±4.3 cm) was predicted by =2.76 (height at initial evaluation - TH) - 3.68 LH/FSH peaks ratio - 3.49; R2=0.77. Time between puberty onset and first menstruation (years) was predicted by =12.2 - 1.06 age CPP - 0.4 (height at initial evaluation - TH); R2=0.75.

Conclusions: A greater difference between height at initial evaluation and TH (SDS) is associated with a greater AH in treated and untreated girls, as are smaller differences between height at initial evaluation and predicted AH in treated and lower LH/FSH peaks ratios in untreated girls.

Show MeSH
Related in: MedlinePlus