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Predicting the adult height of girls with central precocious puberty.

Allali S, Lemaire P, Couto-Silva AC, Prété G, Trivin C, Brauner R - Med. Sci. Monit. (2011)

Bottom Line: Treated: the difference between AH and TH (-0.6±5.4 cm) was predicted by (using SDS) =3.68 (height at initial evaluation - TH) - 1.94 (height at initial evaluation-predicted AH) - 4.23; R2=0.73.Untreated: the difference between AH and TH (1.7±4.3 cm) was predicted by =2.76 (height at initial evaluation - TH) - 3.68 LH/FSH peaks ratio - 3.49; R2=0.77.A greater difference between height at initial evaluation and TH (SDS) is associated with a greater AH in treated and untreated girls, as are smaller differences between height at initial evaluation and predicted AH in treated and lower LH/FSH peaks ratios in untreated girls.

View Article: PubMed Central - PubMed

Affiliation: Université Paris Descartes and AP-HP, Hôpital Bicêtre, Unité d'Endocrinologie Pédiatrique, Paris, France.

ABSTRACT

Background: There are no absolute criteria for identifying those girls with idiopathic central precocious puberty (CPP) who will benefit from gonadotropin-releasing hormone analog (GnRHa) treatment. Our objective was to predict at initial evaluation the differences between adult height (AH) and target height (TH) and (for untreated girls) the time between puberty onset and first menstruation.

Material/methods: The 122 girls with CPP who reached their AH included 70 who were given GnRHa because their predicted AH was <155 cm (n=24), their luteinising hormone (LH)/follicle-stimulating hormone peaks (FSH) ratio was >0.66 (n=41) and/or their estradiol was >15 pg/ml (n=40). The other 52 were untreated because their predicted AH was >155 cm. Multiple linear regressions were performed on several subsets of variables.

Results: Treated: the difference between AH and TH (-0.6±5.4 cm) was predicted by (using SDS) =3.68 (height at initial evaluation - TH) - 1.94 (height at initial evaluation-predicted AH) - 4.23; R2=0.73. Untreated: the difference between AH and TH (1.7±4.3 cm) was predicted by =2.76 (height at initial evaluation - TH) - 3.68 LH/FSH peaks ratio - 3.49; R2=0.77. Time between puberty onset and first menstruation (years) was predicted by =12.2 - 1.06 age CPP - 0.4 (height at initial evaluation - TH); R2=0.75.

Conclusions: A greater difference between height at initial evaluation and TH (SDS) is associated with a greater AH in treated and untreated girls, as are smaller differences between height at initial evaluation and predicted AH in treated and lower LH/FSH peaks ratios in untreated girls.

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Related in: MedlinePlus

Predictions of the difference (cm) between the adult height (AH) and target height (TH) of girls with CPP treated with GnRHa. Straight lines are contour plots, every cm. Each point corresponds to the predicted difference, with the actual difference indicated. The point is changed to a cross when the actual value is more than 3 cm lower than the calculated one. Three patients located in the upper part were deleted.
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f1-medscimonit-17-6-ph41: Predictions of the difference (cm) between the adult height (AH) and target height (TH) of girls with CPP treated with GnRHa. Straight lines are contour plots, every cm. Each point corresponds to the predicted difference, with the actual difference indicated. The point is changed to a cross when the actual value is more than 3 cm lower than the calculated one. Three patients located in the upper part were deleted.

Mentions: The difference between the AH and TH was −0.6±5.4 (−15.5 to 15) cm, and was positively correlated with the height at treatment initiation and the predicted AH. This difference (cm) can be predicted at the initial evaluation by the formula (using SDS) =3.68 (height at initial evaluation – TH) − 1.94 (height at initial evaluation – predicted AH) − 4.23 with R2=0.73 (Figure 1).


Predicting the adult height of girls with central precocious puberty.

Allali S, Lemaire P, Couto-Silva AC, Prété G, Trivin C, Brauner R - Med. Sci. Monit. (2011)

Predictions of the difference (cm) between the adult height (AH) and target height (TH) of girls with CPP treated with GnRHa. Straight lines are contour plots, every cm. Each point corresponds to the predicted difference, with the actual difference indicated. The point is changed to a cross when the actual value is more than 3 cm lower than the calculated one. Three patients located in the upper part were deleted.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3539549&req=5

f1-medscimonit-17-6-ph41: Predictions of the difference (cm) between the adult height (AH) and target height (TH) of girls with CPP treated with GnRHa. Straight lines are contour plots, every cm. Each point corresponds to the predicted difference, with the actual difference indicated. The point is changed to a cross when the actual value is more than 3 cm lower than the calculated one. Three patients located in the upper part were deleted.
Mentions: The difference between the AH and TH was −0.6±5.4 (−15.5 to 15) cm, and was positively correlated with the height at treatment initiation and the predicted AH. This difference (cm) can be predicted at the initial evaluation by the formula (using SDS) =3.68 (height at initial evaluation – TH) − 1.94 (height at initial evaluation – predicted AH) − 4.23 with R2=0.73 (Figure 1).

Bottom Line: Treated: the difference between AH and TH (-0.6±5.4 cm) was predicted by (using SDS) =3.68 (height at initial evaluation - TH) - 1.94 (height at initial evaluation-predicted AH) - 4.23; R2=0.73.Untreated: the difference between AH and TH (1.7±4.3 cm) was predicted by =2.76 (height at initial evaluation - TH) - 3.68 LH/FSH peaks ratio - 3.49; R2=0.77.A greater difference between height at initial evaluation and TH (SDS) is associated with a greater AH in treated and untreated girls, as are smaller differences between height at initial evaluation and predicted AH in treated and lower LH/FSH peaks ratios in untreated girls.

View Article: PubMed Central - PubMed

Affiliation: Université Paris Descartes and AP-HP, Hôpital Bicêtre, Unité d'Endocrinologie Pédiatrique, Paris, France.

ABSTRACT

Background: There are no absolute criteria for identifying those girls with idiopathic central precocious puberty (CPP) who will benefit from gonadotropin-releasing hormone analog (GnRHa) treatment. Our objective was to predict at initial evaluation the differences between adult height (AH) and target height (TH) and (for untreated girls) the time between puberty onset and first menstruation.

Material/methods: The 122 girls with CPP who reached their AH included 70 who were given GnRHa because their predicted AH was <155 cm (n=24), their luteinising hormone (LH)/follicle-stimulating hormone peaks (FSH) ratio was >0.66 (n=41) and/or their estradiol was >15 pg/ml (n=40). The other 52 were untreated because their predicted AH was >155 cm. Multiple linear regressions were performed on several subsets of variables.

Results: Treated: the difference between AH and TH (-0.6±5.4 cm) was predicted by (using SDS) =3.68 (height at initial evaluation - TH) - 1.94 (height at initial evaluation-predicted AH) - 4.23; R2=0.73. Untreated: the difference between AH and TH (1.7±4.3 cm) was predicted by =2.76 (height at initial evaluation - TH) - 3.68 LH/FSH peaks ratio - 3.49; R2=0.77. Time between puberty onset and first menstruation (years) was predicted by =12.2 - 1.06 age CPP - 0.4 (height at initial evaluation - TH); R2=0.75.

Conclusions: A greater difference between height at initial evaluation and TH (SDS) is associated with a greater AH in treated and untreated girls, as are smaller differences between height at initial evaluation and predicted AH in treated and lower LH/FSH peaks ratios in untreated girls.

Show MeSH
Related in: MedlinePlus