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Differential diagnosis of behavioral variant of fronto-temporal dementia (bvFTD).

Pąchalska M, Bidzan L, Łukowicz M, Bidzan M, Markiewicz K, Jastrzębowska G, Talar J - Med. Sci. Monit. (2011)

Bottom Line: It was found that FTD patients scored the highest, while the VAD patients scored somewhat lower in the FBInv.In the process of the neurotherapy of FTD patients we found a reduction of the behavioral disturbances, despite the progression of the illness.The results obtained in the present study confirmed the diagnostic value of FBInv in the differential diagnosis of various types of FTD and in the evaluation of neurotherapy efficacy.

View Article: PubMed Central - PubMed

Affiliation: Andrzej Frycz-Modrzewski Cracow University, Cracow, Poland. neuropsychologia23@o2.pl

ABSTRACT

Background: The aim of the paper is the differential diagnosis of various types of Fronto-Temporal Dementia (FTD), with the focus on its behavioural variant (bvFTD).

Material/method: Screening was done in order to assess the depth of dementia with the short version of MMSE, while evaluation of various variants of FTD was performed with the use of such neuropsychological tests as Newcomb and Chicago Fluency Tests, Wechsler Memory Scale-III (WMS-III), Western Aphasia Battery (WAB-R), and the Boston Naming Test (BNT). Behaviour was evaluated with a Polish version of the Frontal Behavioral Inventory (FBInv). The inventory consists of 24 questions which enable an evaluation of social behaviour disorders. The study included 112 patients--68 men and 46 women treated in the Reintegrative-Training Centre of the Foundation for Persons with Brain Dysfunctions in Kraków and in the Clinic for Developmental Psychiatry, Psychotic Disorders and Old Age Psychiatry, of the Medical University at Gdańsk, who were suffering from various types of dementia.

Results: It was found that FTD patients scored the highest, while the VAD patients scored somewhat lower in the FBInv. At the same time the scores obtained by PPA patients were higher in comparison to the control groups, but not as high as in the case of patients with FTD. In the process of the neurotherapy of FTD patients we found a reduction of the behavioral disturbances, despite the progression of the illness.

Conclusions: The results obtained in the present study confirmed the diagnostic value of FBInv in the differential diagnosis of various types of FTD and in the evaluation of neurotherapy efficacy.

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Related in: MedlinePlus

Medial cross-section of the human brain and white matter connections (From: Pachalska and MacQueen [75]).
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f2-medscimonit-17-6-cr311: Medial cross-section of the human brain and white matter connections (From: Pachalska and MacQueen [75]).

Mentions: Ablation of the frontal part of the temporal lobe connected with the bilateral ablation of the amygdalia body in animals is followed by dramatic changes in sexual and aggressive behaviours [30]. Klüver-Bucy syndrome, including hypersexuality, lack of fear reaction and visual agnosia, show how dramatic the results of lesions of the limbic structures for emotional-motivational functions can be. FTD patients often exhibit Klüver-Bucy Syndrome. They exhibit various deviant social behaviors, such as disinhibition, verbal or physical aggression, and executive functions disorders connected with apathy [36]. Lesions leading to the above mentioned pathological behaviours are difficult to grasp. Dysfunctions observed in those patients remind one of the behaviours of animals with lesions disrupting the activity of the limbic system. Microgenetic theory of a symptom [74] developed on the basis of an evolutionary, four-dimensional model of brain work [75] may be of help in understanding those disorders. Damage to the limbic system or of one of its connections with other brain structure including the frontal lobes (Figure 2) disrupts the normal activity of the brain, and due to that basic limbic-cortical dysfunction many patients with dementia exhibit difficulties with “adult” or “civilized” behaviours [36,75].


Differential diagnosis of behavioral variant of fronto-temporal dementia (bvFTD).

Pąchalska M, Bidzan L, Łukowicz M, Bidzan M, Markiewicz K, Jastrzębowska G, Talar J - Med. Sci. Monit. (2011)

Medial cross-section of the human brain and white matter connections (From: Pachalska and MacQueen [75]).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3539546&req=5

f2-medscimonit-17-6-cr311: Medial cross-section of the human brain and white matter connections (From: Pachalska and MacQueen [75]).
Mentions: Ablation of the frontal part of the temporal lobe connected with the bilateral ablation of the amygdalia body in animals is followed by dramatic changes in sexual and aggressive behaviours [30]. Klüver-Bucy syndrome, including hypersexuality, lack of fear reaction and visual agnosia, show how dramatic the results of lesions of the limbic structures for emotional-motivational functions can be. FTD patients often exhibit Klüver-Bucy Syndrome. They exhibit various deviant social behaviors, such as disinhibition, verbal or physical aggression, and executive functions disorders connected with apathy [36]. Lesions leading to the above mentioned pathological behaviours are difficult to grasp. Dysfunctions observed in those patients remind one of the behaviours of animals with lesions disrupting the activity of the limbic system. Microgenetic theory of a symptom [74] developed on the basis of an evolutionary, four-dimensional model of brain work [75] may be of help in understanding those disorders. Damage to the limbic system or of one of its connections with other brain structure including the frontal lobes (Figure 2) disrupts the normal activity of the brain, and due to that basic limbic-cortical dysfunction many patients with dementia exhibit difficulties with “adult” or “civilized” behaviours [36,75].

Bottom Line: It was found that FTD patients scored the highest, while the VAD patients scored somewhat lower in the FBInv.In the process of the neurotherapy of FTD patients we found a reduction of the behavioral disturbances, despite the progression of the illness.The results obtained in the present study confirmed the diagnostic value of FBInv in the differential diagnosis of various types of FTD and in the evaluation of neurotherapy efficacy.

View Article: PubMed Central - PubMed

Affiliation: Andrzej Frycz-Modrzewski Cracow University, Cracow, Poland. neuropsychologia23@o2.pl

ABSTRACT

Background: The aim of the paper is the differential diagnosis of various types of Fronto-Temporal Dementia (FTD), with the focus on its behavioural variant (bvFTD).

Material/method: Screening was done in order to assess the depth of dementia with the short version of MMSE, while evaluation of various variants of FTD was performed with the use of such neuropsychological tests as Newcomb and Chicago Fluency Tests, Wechsler Memory Scale-III (WMS-III), Western Aphasia Battery (WAB-R), and the Boston Naming Test (BNT). Behaviour was evaluated with a Polish version of the Frontal Behavioral Inventory (FBInv). The inventory consists of 24 questions which enable an evaluation of social behaviour disorders. The study included 112 patients--68 men and 46 women treated in the Reintegrative-Training Centre of the Foundation for Persons with Brain Dysfunctions in Kraków and in the Clinic for Developmental Psychiatry, Psychotic Disorders and Old Age Psychiatry, of the Medical University at Gdańsk, who were suffering from various types of dementia.

Results: It was found that FTD patients scored the highest, while the VAD patients scored somewhat lower in the FBInv. At the same time the scores obtained by PPA patients were higher in comparison to the control groups, but not as high as in the case of patients with FTD. In the process of the neurotherapy of FTD patients we found a reduction of the behavioral disturbances, despite the progression of the illness.

Conclusions: The results obtained in the present study confirmed the diagnostic value of FBInv in the differential diagnosis of various types of FTD and in the evaluation of neurotherapy efficacy.

Show MeSH
Related in: MedlinePlus