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An animal model of femoral head osteonecrosis induced by a single injection of absolute alcohol: an experimental study.

Zhu ZH, Gao YS, Luo SH, Zeng BF, Zhang CQ - Med. Sci. Monit. (2011)

Bottom Line: Macrostructural and radiographic examinations revealed that the contour of both femoral heads was deformed slightly at 12 weeks, but a contour deformation with joint space narrowing was observed at 25 weeks.Histologically, a strong concordance with the natural history of ONFH in humans was found.The present model demonstrated bone trabeculae, marrow necrosis, a reconstruction deficiency and destruction of the microcirculation.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopedic Surgery, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, China.

ABSTRACT

Background: The lack of an experimental animal model that can reliably mimic all stages of osteonecrosis of the femoral head has hindered progress toward the successful prevention and treatment of the disease.

Material/methods: A goat model of osteonecrosis of the femoral head (ONFH) was established and observed from the early to the intermediate-to-late stage of mechanical failure. Absolute alcohol was injected slowly into the center of bilateral femoral heads in 12 adult Small Tail Han goats. Postoperatively, the femoral heads were harvested and examined using macrostructural and histological analyses and radiographic and MRI examinations at weeks 4, 8, 12, and 25.

Results: Macrostructural and radiographic examinations revealed that the contour of both femoral heads was deformed slightly at 12 weeks, but a contour deformation with joint space narrowing was observed at 25 weeks. Histologically, a strong concordance with the natural history of ONFH in humans was found. The present model demonstrated bone trabeculae, marrow necrosis, a reconstruction deficiency and destruction of the microcirculation.

Conclusions: Among quadrupedal models, the goat model of ONFH, which is induced by a single injection of absolute alcohol, may be suitable and valuable for the evaluation of various therapeutics and side effects in the treatment of ONFH.

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The contour of the femoral head was deformed at week 25. The joint surface was not smooth and cartilage was damaged.
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f1-medscimonit-17-4-br97: The contour of the femoral head was deformed at week 25. The joint surface was not smooth and cartilage was damaged.

Mentions: At 4 and 8 weeks postoperatively, the articular surfaces and the femoral heads were intact. Osteonecrosis was observed around the drill track and demonstrated a decrease with an increase in distance to the tip of the drill track. At 12 weeks, 3 experimental goats were examined, and 5 articular surfaces demonstrated a local loss of luster. The defect of the articular cartilage was observed at 25 weeks (Figure 1).


An animal model of femoral head osteonecrosis induced by a single injection of absolute alcohol: an experimental study.

Zhu ZH, Gao YS, Luo SH, Zeng BF, Zhang CQ - Med. Sci. Monit. (2011)

The contour of the femoral head was deformed at week 25. The joint surface was not smooth and cartilage was damaged.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3539532&req=5

f1-medscimonit-17-4-br97: The contour of the femoral head was deformed at week 25. The joint surface was not smooth and cartilage was damaged.
Mentions: At 4 and 8 weeks postoperatively, the articular surfaces and the femoral heads were intact. Osteonecrosis was observed around the drill track and demonstrated a decrease with an increase in distance to the tip of the drill track. At 12 weeks, 3 experimental goats were examined, and 5 articular surfaces demonstrated a local loss of luster. The defect of the articular cartilage was observed at 25 weeks (Figure 1).

Bottom Line: Macrostructural and radiographic examinations revealed that the contour of both femoral heads was deformed slightly at 12 weeks, but a contour deformation with joint space narrowing was observed at 25 weeks.Histologically, a strong concordance with the natural history of ONFH in humans was found.The present model demonstrated bone trabeculae, marrow necrosis, a reconstruction deficiency and destruction of the microcirculation.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopedic Surgery, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, China.

ABSTRACT

Background: The lack of an experimental animal model that can reliably mimic all stages of osteonecrosis of the femoral head has hindered progress toward the successful prevention and treatment of the disease.

Material/methods: A goat model of osteonecrosis of the femoral head (ONFH) was established and observed from the early to the intermediate-to-late stage of mechanical failure. Absolute alcohol was injected slowly into the center of bilateral femoral heads in 12 adult Small Tail Han goats. Postoperatively, the femoral heads were harvested and examined using macrostructural and histological analyses and radiographic and MRI examinations at weeks 4, 8, 12, and 25.

Results: Macrostructural and radiographic examinations revealed that the contour of both femoral heads was deformed slightly at 12 weeks, but a contour deformation with joint space narrowing was observed at 25 weeks. Histologically, a strong concordance with the natural history of ONFH in humans was found. The present model demonstrated bone trabeculae, marrow necrosis, a reconstruction deficiency and destruction of the microcirculation.

Conclusions: Among quadrupedal models, the goat model of ONFH, which is induced by a single injection of absolute alcohol, may be suitable and valuable for the evaluation of various therapeutics and side effects in the treatment of ONFH.

Show MeSH
Related in: MedlinePlus