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Increased plasma peroxides as a marker of oxidative stress in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).

Maes M, Kubera M, Uytterhoeven M, Vrydags N, Bosmans E - Med. Sci. Monit. (2011)

Bottom Line: There was a trend towards significantly higher serum oxLDL antibodies in ME/CFS than in controls.Plasma peroxide and serum oxLDL antibody levels were both significantly related to one of the FF symptoms.The results show that ME/CFS is characterized by increased oxidative stress.

View Article: PubMed Central - PubMed

Affiliation: Maes Clinics@TRIA, Bangkok, Thailand. dr.michaelmaes@hotmail.com

ABSTRACT

Background: There is evidence that myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized by activation of immune, inflammatory, oxidative and nitrosative stress (IO&NS) pathways. The present study was carried out in order to examine whether ME/CFS is accompanied by increased levels of plasma peroxides and serum oxidized LDL (oxLDL) antibodies, two biomarkers of oxidative stress.

Material/methods: Blood was collected from 56 patients with ME/CFS and 37 normal volunteers. Severity of ME/CFS was measured using the Fibromyalgia and Chronic Fatigue Syndrome (FF) Rating Scale.

Results: Plasma peroxide concentrations were significantly higher in patients with ME/CFS than in normal controls. There was a trend towards significantly higher serum oxLDL antibodies in ME/CFS than in controls. Both biomarkers contributed significantly in discriminating between patients with ME/CFS and normal controls. Plasma peroxide and serum oxLDL antibody levels were both significantly related to one of the FF symptoms.

Conclusions: The results show that ME/CFS is characterized by increased oxidative stress.

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Related in: MedlinePlus

Scatter plot of the oxidized LDL antibodies (in mU/mL and in Box-Cox transformation) in normal controls (1.0) and ME/CFS patients (2.0).
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f2-medscimonit-17-4-sc11: Scatter plot of the oxidized LDL antibodies (in mU/mL and in Box-Cox transformation) in normal controls (1.0) and ME/CFS patients (2.0).

Mentions: Figure 2 shows that there is a trend towards higher oxLDL antibodies in ME/CFS patients than in normal controls. A factorial ANCOVA with diagnosis and gender as factors and age as covariate showed no significant differences in serum oxLDL antibodies between ME/CFS and controls (F=1.8, df=1/83, p=0.2), no significant gender (F=0.1, df=1/83, p=0.70) and age (F=2.5, df=1/83, p=0.09) effects, and no significant interaction between diagnosis and gender (F=1.8, p=1/83, p=0.20). The serum oxLDL antibodies showed no significant diagnostic performance for ME/CFS, where the area under the ROC curve was only 62.7%.


Increased plasma peroxides as a marker of oxidative stress in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).

Maes M, Kubera M, Uytterhoeven M, Vrydags N, Bosmans E - Med. Sci. Monit. (2011)

Scatter plot of the oxidized LDL antibodies (in mU/mL and in Box-Cox transformation) in normal controls (1.0) and ME/CFS patients (2.0).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3539515&req=5

f2-medscimonit-17-4-sc11: Scatter plot of the oxidized LDL antibodies (in mU/mL and in Box-Cox transformation) in normal controls (1.0) and ME/CFS patients (2.0).
Mentions: Figure 2 shows that there is a trend towards higher oxLDL antibodies in ME/CFS patients than in normal controls. A factorial ANCOVA with diagnosis and gender as factors and age as covariate showed no significant differences in serum oxLDL antibodies between ME/CFS and controls (F=1.8, df=1/83, p=0.2), no significant gender (F=0.1, df=1/83, p=0.70) and age (F=2.5, df=1/83, p=0.09) effects, and no significant interaction between diagnosis and gender (F=1.8, p=1/83, p=0.20). The serum oxLDL antibodies showed no significant diagnostic performance for ME/CFS, where the area under the ROC curve was only 62.7%.

Bottom Line: There was a trend towards significantly higher serum oxLDL antibodies in ME/CFS than in controls.Plasma peroxide and serum oxLDL antibody levels were both significantly related to one of the FF symptoms.The results show that ME/CFS is characterized by increased oxidative stress.

View Article: PubMed Central - PubMed

Affiliation: Maes Clinics@TRIA, Bangkok, Thailand. dr.michaelmaes@hotmail.com

ABSTRACT

Background: There is evidence that myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized by activation of immune, inflammatory, oxidative and nitrosative stress (IO&NS) pathways. The present study was carried out in order to examine whether ME/CFS is accompanied by increased levels of plasma peroxides and serum oxidized LDL (oxLDL) antibodies, two biomarkers of oxidative stress.

Material/methods: Blood was collected from 56 patients with ME/CFS and 37 normal volunteers. Severity of ME/CFS was measured using the Fibromyalgia and Chronic Fatigue Syndrome (FF) Rating Scale.

Results: Plasma peroxide concentrations were significantly higher in patients with ME/CFS than in normal controls. There was a trend towards significantly higher serum oxLDL antibodies in ME/CFS than in controls. Both biomarkers contributed significantly in discriminating between patients with ME/CFS and normal controls. Plasma peroxide and serum oxLDL antibody levels were both significantly related to one of the FF symptoms.

Conclusions: The results show that ME/CFS is characterized by increased oxidative stress.

Show MeSH
Related in: MedlinePlus