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Alteration of antioxidant defense status precedes humoral immune response abnormalities in macrosomia.

Haddouche M, Aribi M, Moulessehoul S, Smahi MC, Lammani M, Benyoucef M - Med. Sci. Monit. (2011)

Bottom Line: Moreover, macrosomia was significantly associated with high levels of complement C3 (OR=8, p=0.002); whereas no association with those of IgG was observed (OR<1, p>0.05).Furthermore, macrosomia was significantly associated with low levels of ORAC (OR=4.96, p=0.027), vitamin E (OR=4.5, p=0.018), SOD (OR=6.88, p=0.020) and CAT (OR=5.67, p=0.017), and with high levels of MDA (OR=10.29, p=0.005).Additionally, excessive weight could be a potential factor contributing to decreased anti-oxidative capacity and increased oxidative stress.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Applied Molecular Biology and Immunology, Tlemcen Abou-Bekr Belkaid University, Tlemcen, Algeria.

ABSTRACT

Background: This study aimed to investigate whether the anomalies affecting the antioxidant and humoral immune defenses could start at birth and to check whether the decrease in antioxidant defenses may precede the immune abnormalities in macrosomic newborns.

Material/methods: Thirty macrosomic and 30 sex-matched control newborns were recruited for a retrospective case-control study at the Maghnia Maternity Hospital of Tlemcen Department (Algeria).

Results: The serum IgG levels were similar in both groups. However, plasma ORAC, albumin, vitamin E, SOD, CAT and GSH-Px levels were significantly decreased in macrosomic as compared to control newborns, yet no difference was observed after adjustment for weight. Additionally, serum concentrations of complement C3, MDA and XO were significantly higher in macrosomic as compared to controls before adjustment for weight. Moreover, macrosomia was significantly associated with high levels of complement C3 (OR=8, p=0.002); whereas no association with those of IgG was observed (OR<1, p>0.05). Furthermore, macrosomia was significantly associated with low levels of ORAC (OR=4.96, p=0.027), vitamin E (OR=4.5, p=0.018), SOD (OR=6.88, p=0.020) and CAT (OR=5.67, p=0.017), and with high levels of MDA (OR=10.29, p=0.005).

Conclusions: Abnormalities of the humoral defense system in excessive weight could be preceded by alterations of the anti-oxidative defense and by inflammatory response and activation of innate immunity at birth. Additionally, excessive weight could be a potential factor contributing to decreased anti-oxidative capacity and increased oxidative stress.

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Related in: MedlinePlus

IgG humoral response and complement C3 levels in macrosomic and control newborns. C3 – complement component 3, IgG – Immunoglobulin G. ** p<0.01. The variables are presented as mean ± standard error. p>0.05 after adjustment for birthweight
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f2-medscimonit-17-11-cr650: IgG humoral response and complement C3 levels in macrosomic and control newborns. C3 – complement component 3, IgG – Immunoglobulin G. ** p<0.01. The variables are presented as mean ± standard error. p>0.05 after adjustment for birthweight

Mentions: The plasma levels of ORAC and serum levels of IgG and complement C3 are shown in Figures 1 and 2, respectively.


Alteration of antioxidant defense status precedes humoral immune response abnormalities in macrosomia.

Haddouche M, Aribi M, Moulessehoul S, Smahi MC, Lammani M, Benyoucef M - Med. Sci. Monit. (2011)

IgG humoral response and complement C3 levels in macrosomic and control newborns. C3 – complement component 3, IgG – Immunoglobulin G. ** p<0.01. The variables are presented as mean ± standard error. p>0.05 after adjustment for birthweight
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3539498&req=5

f2-medscimonit-17-11-cr650: IgG humoral response and complement C3 levels in macrosomic and control newborns. C3 – complement component 3, IgG – Immunoglobulin G. ** p<0.01. The variables are presented as mean ± standard error. p>0.05 after adjustment for birthweight
Mentions: The plasma levels of ORAC and serum levels of IgG and complement C3 are shown in Figures 1 and 2, respectively.

Bottom Line: Moreover, macrosomia was significantly associated with high levels of complement C3 (OR=8, p=0.002); whereas no association with those of IgG was observed (OR<1, p>0.05).Furthermore, macrosomia was significantly associated with low levels of ORAC (OR=4.96, p=0.027), vitamin E (OR=4.5, p=0.018), SOD (OR=6.88, p=0.020) and CAT (OR=5.67, p=0.017), and with high levels of MDA (OR=10.29, p=0.005).Additionally, excessive weight could be a potential factor contributing to decreased anti-oxidative capacity and increased oxidative stress.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Applied Molecular Biology and Immunology, Tlemcen Abou-Bekr Belkaid University, Tlemcen, Algeria.

ABSTRACT

Background: This study aimed to investigate whether the anomalies affecting the antioxidant and humoral immune defenses could start at birth and to check whether the decrease in antioxidant defenses may precede the immune abnormalities in macrosomic newborns.

Material/methods: Thirty macrosomic and 30 sex-matched control newborns were recruited for a retrospective case-control study at the Maghnia Maternity Hospital of Tlemcen Department (Algeria).

Results: The serum IgG levels were similar in both groups. However, plasma ORAC, albumin, vitamin E, SOD, CAT and GSH-Px levels were significantly decreased in macrosomic as compared to control newborns, yet no difference was observed after adjustment for weight. Additionally, serum concentrations of complement C3, MDA and XO were significantly higher in macrosomic as compared to controls before adjustment for weight. Moreover, macrosomia was significantly associated with high levels of complement C3 (OR=8, p=0.002); whereas no association with those of IgG was observed (OR<1, p>0.05). Furthermore, macrosomia was significantly associated with low levels of ORAC (OR=4.96, p=0.027), vitamin E (OR=4.5, p=0.018), SOD (OR=6.88, p=0.020) and CAT (OR=5.67, p=0.017), and with high levels of MDA (OR=10.29, p=0.005).

Conclusions: Abnormalities of the humoral defense system in excessive weight could be preceded by alterations of the anti-oxidative defense and by inflammatory response and activation of innate immunity at birth. Additionally, excessive weight could be a potential factor contributing to decreased anti-oxidative capacity and increased oxidative stress.

Show MeSH
Related in: MedlinePlus