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Usefulness of marking alkaline phosphatase and C-reactive protein in monitoring the risk of preterm delivery.

Huras H, Ossowski P, Jach R, Reron A - Med. Sci. Monit. (2011)

Bottom Line: In more than half of women (72.1%) from study group, CRP level exceeded 7 mg/l; in the control group, the CRP level exceeded 7 mg/l in 35% of cases.Significantly higher levels of CRP (above 20 mg/l) and ALP (above 300 u/l) were found in the 18 patients from the study group compared to the control group.Although an increase in the level of ALP in serum cannot be an absolute and sole marker of the risk of preterm delivery, it can be used in conjunction with a significantly elevated CRP level.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Perinatology Jagiellonian University, Cracow, Poland. huberthuras@wp.pl

ABSTRACT

Background: The purpose of this paper is to compare the effectiveness of use of alkaline phosphatase (ALP) and C-reactive protein (CRP) levels in marking and monitoring the risk of preterm delivery due to infection.

Material/methods: The study involved 83 patients assigned to groups: Group I (n=43) consisted of patients hospitalized for symptoms of preterm delivery, and Group II (control group n=40) consisted of patients controlled or hospitalized delivering on time without complications, whose pregnancy had a physiological course. All patients had a single marking of ALP and CRP levels in serum performed.

Results: CRP levels were within the range 7 mg/l to 94 mg/l in the study group, and 4.83 mg/l to 90 mg/l in the control group. The level of ALP in the study group ranged from 139 u/l to 368 u/l and from 218 u/l to 321 u/l in the control group. In more than half of women (72.1%) from study group, CRP level exceeded 7 mg/l; in the control group, the CRP level exceeded 7 mg/l in 35% of cases. Significantly higher levels of CRP (above 20 mg/l) and ALP (above 300 u/l) were found in the 18 patients from the study group compared to the control group.

Conclusions: Although an increase in the level of ALP in serum cannot be an absolute and sole marker of the risk of preterm delivery, it can be used in conjunction with a significantly elevated CRP level.

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Related in: MedlinePlus

Dependence of ALP and CRP levels on week of gestation.
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f5-medscimonit-17-11-cr657: Dependence of ALP and CRP levels on week of gestation.

Mentions: Figure 5 presents the dependence between the time of gestation and the levels of CRP and ALP. Due to high dispersion in results, medians were used to observe the general tendency. The figure shows that together with the period of gestation, the values of medians grow for both CRP and ALP. The growth in time is statistically significant at the level of p=0.05. A standard T test was used for testing of significance of slopes in linear regression models (Figure 5).


Usefulness of marking alkaline phosphatase and C-reactive protein in monitoring the risk of preterm delivery.

Huras H, Ossowski P, Jach R, Reron A - Med. Sci. Monit. (2011)

Dependence of ALP and CRP levels on week of gestation.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3539487&req=5

f5-medscimonit-17-11-cr657: Dependence of ALP and CRP levels on week of gestation.
Mentions: Figure 5 presents the dependence between the time of gestation and the levels of CRP and ALP. Due to high dispersion in results, medians were used to observe the general tendency. The figure shows that together with the period of gestation, the values of medians grow for both CRP and ALP. The growth in time is statistically significant at the level of p=0.05. A standard T test was used for testing of significance of slopes in linear regression models (Figure 5).

Bottom Line: In more than half of women (72.1%) from study group, CRP level exceeded 7 mg/l; in the control group, the CRP level exceeded 7 mg/l in 35% of cases.Significantly higher levels of CRP (above 20 mg/l) and ALP (above 300 u/l) were found in the 18 patients from the study group compared to the control group.Although an increase in the level of ALP in serum cannot be an absolute and sole marker of the risk of preterm delivery, it can be used in conjunction with a significantly elevated CRP level.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Perinatology Jagiellonian University, Cracow, Poland. huberthuras@wp.pl

ABSTRACT

Background: The purpose of this paper is to compare the effectiveness of use of alkaline phosphatase (ALP) and C-reactive protein (CRP) levels in marking and monitoring the risk of preterm delivery due to infection.

Material/methods: The study involved 83 patients assigned to groups: Group I (n=43) consisted of patients hospitalized for symptoms of preterm delivery, and Group II (control group n=40) consisted of patients controlled or hospitalized delivering on time without complications, whose pregnancy had a physiological course. All patients had a single marking of ALP and CRP levels in serum performed.

Results: CRP levels were within the range 7 mg/l to 94 mg/l in the study group, and 4.83 mg/l to 90 mg/l in the control group. The level of ALP in the study group ranged from 139 u/l to 368 u/l and from 218 u/l to 321 u/l in the control group. In more than half of women (72.1%) from study group, CRP level exceeded 7 mg/l; in the control group, the CRP level exceeded 7 mg/l in 35% of cases. Significantly higher levels of CRP (above 20 mg/l) and ALP (above 300 u/l) were found in the 18 patients from the study group compared to the control group.

Conclusions: Although an increase in the level of ALP in serum cannot be an absolute and sole marker of the risk of preterm delivery, it can be used in conjunction with a significantly elevated CRP level.

Show MeSH
Related in: MedlinePlus