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Usefulness of marking alkaline phosphatase and C-reactive protein in monitoring the risk of preterm delivery.

Huras H, Ossowski P, Jach R, Reron A - Med. Sci. Monit. (2011)

Bottom Line: In more than half of women (72.1%) from study group, CRP level exceeded 7 mg/l; in the control group, the CRP level exceeded 7 mg/l in 35% of cases.Significantly higher levels of CRP (above 20 mg/l) and ALP (above 300 u/l) were found in the 18 patients from the study group compared to the control group.Although an increase in the level of ALP in serum cannot be an absolute and sole marker of the risk of preterm delivery, it can be used in conjunction with a significantly elevated CRP level.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Perinatology Jagiellonian University, Cracow, Poland. huberthuras@wp.pl

ABSTRACT

Background: The purpose of this paper is to compare the effectiveness of use of alkaline phosphatase (ALP) and C-reactive protein (CRP) levels in marking and monitoring the risk of preterm delivery due to infection.

Material/methods: The study involved 83 patients assigned to groups: Group I (n=43) consisted of patients hospitalized for symptoms of preterm delivery, and Group II (control group n=40) consisted of patients controlled or hospitalized delivering on time without complications, whose pregnancy had a physiological course. All patients had a single marking of ALP and CRP levels in serum performed.

Results: CRP levels were within the range 7 mg/l to 94 mg/l in the study group, and 4.83 mg/l to 90 mg/l in the control group. The level of ALP in the study group ranged from 139 u/l to 368 u/l and from 218 u/l to 321 u/l in the control group. In more than half of women (72.1%) from study group, CRP level exceeded 7 mg/l; in the control group, the CRP level exceeded 7 mg/l in 35% of cases. Significantly higher levels of CRP (above 20 mg/l) and ALP (above 300 u/l) were found in the 18 patients from the study group compared to the control group.

Conclusions: Although an increase in the level of ALP in serum cannot be an absolute and sole marker of the risk of preterm delivery, it can be used in conjunction with a significantly elevated CRP level.

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Distribution of ratio of miscarriage in previous pregnancy in the tested and control group.
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f3-medscimonit-17-11-cr657: Distribution of ratio of miscarriage in previous pregnancy in the tested and control group.

Mentions: The percentage of miscarriages in this study was higher in women at risk of preterm delivery (27.9%) as compared to the control group (12.5%) (Table 3 and Figure 3). The difference is significant at the level of p=0.05. Comparison between distributions was made by non-parametric χ2 test of independence.


Usefulness of marking alkaline phosphatase and C-reactive protein in monitoring the risk of preterm delivery.

Huras H, Ossowski P, Jach R, Reron A - Med. Sci. Monit. (2011)

Distribution of ratio of miscarriage in previous pregnancy in the tested and control group.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3539487&req=5

f3-medscimonit-17-11-cr657: Distribution of ratio of miscarriage in previous pregnancy in the tested and control group.
Mentions: The percentage of miscarriages in this study was higher in women at risk of preterm delivery (27.9%) as compared to the control group (12.5%) (Table 3 and Figure 3). The difference is significant at the level of p=0.05. Comparison between distributions was made by non-parametric χ2 test of independence.

Bottom Line: In more than half of women (72.1%) from study group, CRP level exceeded 7 mg/l; in the control group, the CRP level exceeded 7 mg/l in 35% of cases.Significantly higher levels of CRP (above 20 mg/l) and ALP (above 300 u/l) were found in the 18 patients from the study group compared to the control group.Although an increase in the level of ALP in serum cannot be an absolute and sole marker of the risk of preterm delivery, it can be used in conjunction with a significantly elevated CRP level.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Perinatology Jagiellonian University, Cracow, Poland. huberthuras@wp.pl

ABSTRACT

Background: The purpose of this paper is to compare the effectiveness of use of alkaline phosphatase (ALP) and C-reactive protein (CRP) levels in marking and monitoring the risk of preterm delivery due to infection.

Material/methods: The study involved 83 patients assigned to groups: Group I (n=43) consisted of patients hospitalized for symptoms of preterm delivery, and Group II (control group n=40) consisted of patients controlled or hospitalized delivering on time without complications, whose pregnancy had a physiological course. All patients had a single marking of ALP and CRP levels in serum performed.

Results: CRP levels were within the range 7 mg/l to 94 mg/l in the study group, and 4.83 mg/l to 90 mg/l in the control group. The level of ALP in the study group ranged from 139 u/l to 368 u/l and from 218 u/l to 321 u/l in the control group. In more than half of women (72.1%) from study group, CRP level exceeded 7 mg/l; in the control group, the CRP level exceeded 7 mg/l in 35% of cases. Significantly higher levels of CRP (above 20 mg/l) and ALP (above 300 u/l) were found in the 18 patients from the study group compared to the control group.

Conclusions: Although an increase in the level of ALP in serum cannot be an absolute and sole marker of the risk of preterm delivery, it can be used in conjunction with a significantly elevated CRP level.

Show MeSH
Related in: MedlinePlus