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Bone metabolism assessment, bone metabolism index designation and the determination of its normal values range in young healthy women.

Tryniszewski W, Gadzicki M, Górska-Chrząstek M, Rysz J, Maziarz Z - Med. Sci. Monit. (2011)

Bottom Line: The normal results of basic, biochemical, hormonal and vascular tests were obtained.The examinations of bone turnover markers confirmed the balance between bone formation and bone resorption processes.The quantitative scintigraphic bone examinations provide an alternative to the bone markers examination for obtaining information about bone metabolism.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiological and Isotopic Diagnostics and Therapy, Medical University of Lodz, Lodz, Poland. wieslaw.tryniszewski@umed.lodz.pl

ABSTRACT

Background: Bone metabolism assessment requires the determination of bone mass and quality. The bone metabolism was assessed with the modified bone scintigraphy using 99mTc-MDP. The elaboration of radioisotopic method and program allowed for the assessment of bone metabolism, index of bone metabolism assay and definition of its normal values range with the possibility of clinical application.

Material/methods: We examined 70 healthy young women with normal BMI, in which bone system was assessed with scintigraphic and densitometric examinations, and bone turnover markers definition together with hormonal and biochemical blood tests were performed. Group exclusion examinations were also performed, including basic, biochemical and hormonal blood tests, bone turnover markers and densitometric examinations with DXA technique. The scintigraphic examinations were performed using a gamma camera after 99mTc-MDP injection. After the application of the BONS method and program, the normal values range was determined with the STATISTICA 8 program.

Results: The normal results of basic, biochemical, hormonal and vascular tests were obtained. The examinations of bone turnover markers confirmed the balance between bone formation and bone resorption processes. The normal results of densitometric examinations excluded osteopeny or osteoporosis. The normal values range of IBM in young healthy women was between 84.08 and 105.

Conclusions: The elaborated BONS program and method allow for the quantitative assessment of bone quality and definition of IBM normal values range. The quantitative scintigraphic bone examinations provide an alternative to the bone markers examination for obtaining information about bone metabolism.

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Related in: MedlinePlus

Final report.
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f4-medscimonit-17-10-cr563: Final report.

Mentions: On the basis of the obtained values of both thighs, the symmetry factor of the osteotropic index accumulation in femurs in delayed phase was calculated and the value is presented as a percentage. This parameter had the auxiliary character and was additionally used in the qualification to the examined group. The patients in which the symmetry factor was <95% were excluded from further analysis. The obtained results were registered in 2 reports ascribed to the given examination. Figure 4 shows 1 page of final report.


Bone metabolism assessment, bone metabolism index designation and the determination of its normal values range in young healthy women.

Tryniszewski W, Gadzicki M, Górska-Chrząstek M, Rysz J, Maziarz Z - Med. Sci. Monit. (2011)

Final report.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3539482&req=5

f4-medscimonit-17-10-cr563: Final report.
Mentions: On the basis of the obtained values of both thighs, the symmetry factor of the osteotropic index accumulation in femurs in delayed phase was calculated and the value is presented as a percentage. This parameter had the auxiliary character and was additionally used in the qualification to the examined group. The patients in which the symmetry factor was <95% were excluded from further analysis. The obtained results were registered in 2 reports ascribed to the given examination. Figure 4 shows 1 page of final report.

Bottom Line: The normal results of basic, biochemical, hormonal and vascular tests were obtained.The examinations of bone turnover markers confirmed the balance between bone formation and bone resorption processes.The quantitative scintigraphic bone examinations provide an alternative to the bone markers examination for obtaining information about bone metabolism.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiological and Isotopic Diagnostics and Therapy, Medical University of Lodz, Lodz, Poland. wieslaw.tryniszewski@umed.lodz.pl

ABSTRACT

Background: Bone metabolism assessment requires the determination of bone mass and quality. The bone metabolism was assessed with the modified bone scintigraphy using 99mTc-MDP. The elaboration of radioisotopic method and program allowed for the assessment of bone metabolism, index of bone metabolism assay and definition of its normal values range with the possibility of clinical application.

Material/methods: We examined 70 healthy young women with normal BMI, in which bone system was assessed with scintigraphic and densitometric examinations, and bone turnover markers definition together with hormonal and biochemical blood tests were performed. Group exclusion examinations were also performed, including basic, biochemical and hormonal blood tests, bone turnover markers and densitometric examinations with DXA technique. The scintigraphic examinations were performed using a gamma camera after 99mTc-MDP injection. After the application of the BONS method and program, the normal values range was determined with the STATISTICA 8 program.

Results: The normal results of basic, biochemical, hormonal and vascular tests were obtained. The examinations of bone turnover markers confirmed the balance between bone formation and bone resorption processes. The normal results of densitometric examinations excluded osteopeny or osteoporosis. The normal values range of IBM in young healthy women was between 84.08 and 105.

Conclusions: The elaborated BONS program and method allow for the quantitative assessment of bone quality and definition of IBM normal values range. The quantitative scintigraphic bone examinations provide an alternative to the bone markers examination for obtaining information about bone metabolism.

Show MeSH
Related in: MedlinePlus