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Bone metabolism assessment, bone metabolism index designation and the determination of its normal values range in young healthy women.

Tryniszewski W, Gadzicki M, Górska-Chrząstek M, Rysz J, Maziarz Z - Med. Sci. Monit. (2011)

Bottom Line: The normal results of basic, biochemical, hormonal and vascular tests were obtained.The examinations of bone turnover markers confirmed the balance between bone formation and bone resorption processes.The quantitative scintigraphic bone examinations provide an alternative to the bone markers examination for obtaining information about bone metabolism.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiological and Isotopic Diagnostics and Therapy, Medical University of Lodz, Lodz, Poland. wieslaw.tryniszewski@umed.lodz.pl

ABSTRACT

Background: Bone metabolism assessment requires the determination of bone mass and quality. The bone metabolism was assessed with the modified bone scintigraphy using 99mTc-MDP. The elaboration of radioisotopic method and program allowed for the assessment of bone metabolism, index of bone metabolism assay and definition of its normal values range with the possibility of clinical application.

Material/methods: We examined 70 healthy young women with normal BMI, in which bone system was assessed with scintigraphic and densitometric examinations, and bone turnover markers definition together with hormonal and biochemical blood tests were performed. Group exclusion examinations were also performed, including basic, biochemical and hormonal blood tests, bone turnover markers and densitometric examinations with DXA technique. The scintigraphic examinations were performed using a gamma camera after 99mTc-MDP injection. After the application of the BONS method and program, the normal values range was determined with the STATISTICA 8 program.

Results: The normal results of basic, biochemical, hormonal and vascular tests were obtained. The examinations of bone turnover markers confirmed the balance between bone formation and bone resorption processes. The normal results of densitometric examinations excluded osteopeny or osteoporosis. The normal values range of IBM in young healthy women was between 84.08 and 105.

Conclusions: The elaborated BONS program and method allow for the quantitative assessment of bone quality and definition of IBM normal values range. The quantitative scintigraphic bone examinations provide an alternative to the bone markers examination for obtaining information about bone metabolism.

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Related in: MedlinePlus

The dynamic examination.
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f3-medscimonit-17-10-cr563: The dynamic examination.

Mentions: As a result of multiple analyses of the examinations, 60% of the background separation was established, which guaranteed the automatic ROI generation with the maintenance of the necessary number of calculations for the drawing of curves of the activity changes in the thigh area. To optimize the activity changes in the dynamic phase, the obtained histograms underwent gamma adjusting, in which the point of maximal accumulation was assigned (Figure 3). The beginning of the coordinate system and the point defining the maximum on the curve was joined with the straight and the tangent of the angle between this straight and the ordinate (X axle) was calculated. The values for the right and the left thigh were calculated separately (TG_LEFT, TG_RIGHT) (Figure 3). The value of this parameter describes the speed of the index flow through the vessels of the thighs in vascular phase. The calculated quotient (IN) of those indexes defined the value of the symmetry of the index flow through the analyzed thigh area (Figure 3). It was assumed that for the definition of the normal index values, the full perfusion symmetry should be maintained in all the patients. However, taking into consideration the possible errors in the patients’ positioning, ±5% mistake was allowed, therefore the patients in which 0.95<IN<1.05 was confirmed were qualified for further examinations. After the analysis of the dynamic part, the program analyzed the static picture of the delayed phase 3 hours after the index application. The scintigram was purified from the noises with FCLEAN function and then filtered with a 9-point filter. With the generated indexes, the length of the left thigh bone was measured, and after the definition of the maximal point, the profilegram was traced. For the maximal separation of the bone picture, on the basis of the profilegram curve value, the background was isolated at the level of 40% of maximal value. After that, an auxiliary square ROI with the height equaling half of the femur length was generated and using markers it was positioned exactly in the middle of this bone.


Bone metabolism assessment, bone metabolism index designation and the determination of its normal values range in young healthy women.

Tryniszewski W, Gadzicki M, Górska-Chrząstek M, Rysz J, Maziarz Z - Med. Sci. Monit. (2011)

The dynamic examination.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3539482&req=5

f3-medscimonit-17-10-cr563: The dynamic examination.
Mentions: As a result of multiple analyses of the examinations, 60% of the background separation was established, which guaranteed the automatic ROI generation with the maintenance of the necessary number of calculations for the drawing of curves of the activity changes in the thigh area. To optimize the activity changes in the dynamic phase, the obtained histograms underwent gamma adjusting, in which the point of maximal accumulation was assigned (Figure 3). The beginning of the coordinate system and the point defining the maximum on the curve was joined with the straight and the tangent of the angle between this straight and the ordinate (X axle) was calculated. The values for the right and the left thigh were calculated separately (TG_LEFT, TG_RIGHT) (Figure 3). The value of this parameter describes the speed of the index flow through the vessels of the thighs in vascular phase. The calculated quotient (IN) of those indexes defined the value of the symmetry of the index flow through the analyzed thigh area (Figure 3). It was assumed that for the definition of the normal index values, the full perfusion symmetry should be maintained in all the patients. However, taking into consideration the possible errors in the patients’ positioning, ±5% mistake was allowed, therefore the patients in which 0.95<IN<1.05 was confirmed were qualified for further examinations. After the analysis of the dynamic part, the program analyzed the static picture of the delayed phase 3 hours after the index application. The scintigram was purified from the noises with FCLEAN function and then filtered with a 9-point filter. With the generated indexes, the length of the left thigh bone was measured, and after the definition of the maximal point, the profilegram was traced. For the maximal separation of the bone picture, on the basis of the profilegram curve value, the background was isolated at the level of 40% of maximal value. After that, an auxiliary square ROI with the height equaling half of the femur length was generated and using markers it was positioned exactly in the middle of this bone.

Bottom Line: The normal results of basic, biochemical, hormonal and vascular tests were obtained.The examinations of bone turnover markers confirmed the balance between bone formation and bone resorption processes.The quantitative scintigraphic bone examinations provide an alternative to the bone markers examination for obtaining information about bone metabolism.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiological and Isotopic Diagnostics and Therapy, Medical University of Lodz, Lodz, Poland. wieslaw.tryniszewski@umed.lodz.pl

ABSTRACT

Background: Bone metabolism assessment requires the determination of bone mass and quality. The bone metabolism was assessed with the modified bone scintigraphy using 99mTc-MDP. The elaboration of radioisotopic method and program allowed for the assessment of bone metabolism, index of bone metabolism assay and definition of its normal values range with the possibility of clinical application.

Material/methods: We examined 70 healthy young women with normal BMI, in which bone system was assessed with scintigraphic and densitometric examinations, and bone turnover markers definition together with hormonal and biochemical blood tests were performed. Group exclusion examinations were also performed, including basic, biochemical and hormonal blood tests, bone turnover markers and densitometric examinations with DXA technique. The scintigraphic examinations were performed using a gamma camera after 99mTc-MDP injection. After the application of the BONS method and program, the normal values range was determined with the STATISTICA 8 program.

Results: The normal results of basic, biochemical, hormonal and vascular tests were obtained. The examinations of bone turnover markers confirmed the balance between bone formation and bone resorption processes. The normal results of densitometric examinations excluded osteopeny or osteoporosis. The normal values range of IBM in young healthy women was between 84.08 and 105.

Conclusions: The elaborated BONS program and method allow for the quantitative assessment of bone quality and definition of IBM normal values range. The quantitative scintigraphic bone examinations provide an alternative to the bone markers examination for obtaining information about bone metabolism.

Show MeSH
Related in: MedlinePlus