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Bone metabolism assessment, bone metabolism index designation and the determination of its normal values range in young healthy women.

Tryniszewski W, Gadzicki M, Górska-Chrząstek M, Rysz J, Maziarz Z - Med. Sci. Monit. (2011)

Bottom Line: The normal results of basic, biochemical, hormonal and vascular tests were obtained.The examinations of bone turnover markers confirmed the balance between bone formation and bone resorption processes.The quantitative scintigraphic bone examinations provide an alternative to the bone markers examination for obtaining information about bone metabolism.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiological and Isotopic Diagnostics and Therapy, Medical University of Lodz, Lodz, Poland. wieslaw.tryniszewski@umed.lodz.pl

ABSTRACT

Background: Bone metabolism assessment requires the determination of bone mass and quality. The bone metabolism was assessed with the modified bone scintigraphy using 99mTc-MDP. The elaboration of radioisotopic method and program allowed for the assessment of bone metabolism, index of bone metabolism assay and definition of its normal values range with the possibility of clinical application.

Material/methods: We examined 70 healthy young women with normal BMI, in which bone system was assessed with scintigraphic and densitometric examinations, and bone turnover markers definition together with hormonal and biochemical blood tests were performed. Group exclusion examinations were also performed, including basic, biochemical and hormonal blood tests, bone turnover markers and densitometric examinations with DXA technique. The scintigraphic examinations were performed using a gamma camera after 99mTc-MDP injection. After the application of the BONS method and program, the normal values range was determined with the STATISTICA 8 program.

Results: The normal results of basic, biochemical, hormonal and vascular tests were obtained. The examinations of bone turnover markers confirmed the balance between bone formation and bone resorption processes. The normal results of densitometric examinations excluded osteopeny or osteoporosis. The normal values range of IBM in young healthy women was between 84.08 and 105.

Conclusions: The elaborated BONS program and method allow for the quantitative assessment of bone quality and definition of IBM normal values range. The quantitative scintigraphic bone examinations provide an alternative to the bone markers examination for obtaining information about bone metabolism.

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f1-medscimonit-17-10-cr563: Whole body.

Mentions: Radiopharmaceutic 99mTc-MDP was used for the bone metabolism assessment. The distribution of the radiopharmaceutic is proportional to the size of the thigh blood flow and the intensification of osteoblastic processes, due to which about 60–80% of the given dose is accumulated in the bones. The maximal accumulation is observed after 2 hours of the injection and it remains unchanged for 72 hours. Radioisotopic examinations of the bone system were performed our own method and the BONS program. The program consists of 3 parts. The first part defines the acquisition parameters and facilitates the correction of the renewed patient’s position in the delayed phase for the proper acquisition of the analyzed region of interest (ROI). The second part – femur dynamic examination – was used for verification in the range of perfusion symmetry and the lack of lower limbs perfusion disturbances. The third part was definition of IBM with the applied program. The acquisition consisted of 2 parts (dynamic and static) and was performed with an APEX SP-6HR gamma camera with high-definition 5-HR. After the positioning of the camera head in P-A projection in the area of the femur and the injection of Tc99mMDP with 11.1 MBq/kg b.m. activity, 120 1-second pictures and 56 5-second pictures were registered (the dynamic phase lasted 5 min.). The dynamic acquisition was recorded in a 128×128 matrix. Next, the whole body scintigram was performed in P-A projection with the head constant speed of 38 cm/min. The static acquisition of femurs (delayed phase) was performed after 3 hours in P-A projection in 300 sec. in a 256/256 matrix. The analysis of the registered pictures was as follows. The whole body scintigram was put into 1 picture which, after purification from the background noise and filtration with a 9-point filter, was automatically described by ROI. On the basis of the information contained in this ROI (Figure 1), the number of calculations for 1 pixel of the matrix (in the further part of the program defined as the density of the whole body calculations) was established and registered in the symbol table. Then the pictures from the dynamic part were grouped into 1 5-minute picture for the profilegram of the picture establishment (Figure 2). From the obtained data, the ROI describing the muscles of this thigh in which the maximal accumulation point was defined was traced. The mirror ROI was put onto the other limb.


Bone metabolism assessment, bone metabolism index designation and the determination of its normal values range in young healthy women.

Tryniszewski W, Gadzicki M, Górska-Chrząstek M, Rysz J, Maziarz Z - Med. Sci. Monit. (2011)

Whole body.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3539482&req=5

f1-medscimonit-17-10-cr563: Whole body.
Mentions: Radiopharmaceutic 99mTc-MDP was used for the bone metabolism assessment. The distribution of the radiopharmaceutic is proportional to the size of the thigh blood flow and the intensification of osteoblastic processes, due to which about 60–80% of the given dose is accumulated in the bones. The maximal accumulation is observed after 2 hours of the injection and it remains unchanged for 72 hours. Radioisotopic examinations of the bone system were performed our own method and the BONS program. The program consists of 3 parts. The first part defines the acquisition parameters and facilitates the correction of the renewed patient’s position in the delayed phase for the proper acquisition of the analyzed region of interest (ROI). The second part – femur dynamic examination – was used for verification in the range of perfusion symmetry and the lack of lower limbs perfusion disturbances. The third part was definition of IBM with the applied program. The acquisition consisted of 2 parts (dynamic and static) and was performed with an APEX SP-6HR gamma camera with high-definition 5-HR. After the positioning of the camera head in P-A projection in the area of the femur and the injection of Tc99mMDP with 11.1 MBq/kg b.m. activity, 120 1-second pictures and 56 5-second pictures were registered (the dynamic phase lasted 5 min.). The dynamic acquisition was recorded in a 128×128 matrix. Next, the whole body scintigram was performed in P-A projection with the head constant speed of 38 cm/min. The static acquisition of femurs (delayed phase) was performed after 3 hours in P-A projection in 300 sec. in a 256/256 matrix. The analysis of the registered pictures was as follows. The whole body scintigram was put into 1 picture which, after purification from the background noise and filtration with a 9-point filter, was automatically described by ROI. On the basis of the information contained in this ROI (Figure 1), the number of calculations for 1 pixel of the matrix (in the further part of the program defined as the density of the whole body calculations) was established and registered in the symbol table. Then the pictures from the dynamic part were grouped into 1 5-minute picture for the profilegram of the picture establishment (Figure 2). From the obtained data, the ROI describing the muscles of this thigh in which the maximal accumulation point was defined was traced. The mirror ROI was put onto the other limb.

Bottom Line: The normal results of basic, biochemical, hormonal and vascular tests were obtained.The examinations of bone turnover markers confirmed the balance between bone formation and bone resorption processes.The quantitative scintigraphic bone examinations provide an alternative to the bone markers examination for obtaining information about bone metabolism.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiological and Isotopic Diagnostics and Therapy, Medical University of Lodz, Lodz, Poland. wieslaw.tryniszewski@umed.lodz.pl

ABSTRACT

Background: Bone metabolism assessment requires the determination of bone mass and quality. The bone metabolism was assessed with the modified bone scintigraphy using 99mTc-MDP. The elaboration of radioisotopic method and program allowed for the assessment of bone metabolism, index of bone metabolism assay and definition of its normal values range with the possibility of clinical application.

Material/methods: We examined 70 healthy young women with normal BMI, in which bone system was assessed with scintigraphic and densitometric examinations, and bone turnover markers definition together with hormonal and biochemical blood tests were performed. Group exclusion examinations were also performed, including basic, biochemical and hormonal blood tests, bone turnover markers and densitometric examinations with DXA technique. The scintigraphic examinations were performed using a gamma camera after 99mTc-MDP injection. After the application of the BONS method and program, the normal values range was determined with the STATISTICA 8 program.

Results: The normal results of basic, biochemical, hormonal and vascular tests were obtained. The examinations of bone turnover markers confirmed the balance between bone formation and bone resorption processes. The normal results of densitometric examinations excluded osteopeny or osteoporosis. The normal values range of IBM in young healthy women was between 84.08 and 105.

Conclusions: The elaborated BONS program and method allow for the quantitative assessment of bone quality and definition of IBM normal values range. The quantitative scintigraphic bone examinations provide an alternative to the bone markers examination for obtaining information about bone metabolism.

Show MeSH
Related in: MedlinePlus