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IGF-I and IGFBP-3 before and after inpatient alcohol detoxification in alcohol-dependent subjects.

Ilias I, Paparrigopoulos T, Tzavellas E, Karaiskos D, Kontoleon P, Liappas I - Med. Sci. Monit. (2011)

Bottom Line: No participants dropped out of the study.Overall, however, IGF-I and IGFBP-3 were within normal limits for most subjects both upon admission and after alcohol detoxification; no significant differences were detected among the examined parameters in men vs. women, and there were no significant correlations of IGF-I, IGFBP-3 or the IGF-I/IGFBP-3 molar ratio with BMI or age.Regardless of hepatic enzymes' elevation, alcohol detoxification had overall slight effects on IGF-I and IGFBP-3.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology, Diabetes and Metabolism, Elena Venizelou Hospital, Athens, Greece. iiliasmd@yahoo.com

ABSTRACT

Background: It is unclear whether alcohol detoxification has an effect on factors that are involved in growth, metabolic functions and cell proliferation. Alcohol abuse is associated with low IGF-I levels that tend to rise after alcohol withdrawal. There is a paucity of studies on the course of IGFBP-3 (the main binding protein for IGF-I) after alcohol detoxification.

Material/methods: We prospectively assessed IGF-I and IGFBP-3 changes at the time of admission and after 4 to 6 weeks of detoxification in an inpatient alcohol detoxification facility in 118 alcohol-dependent subjects given a regular hospital diet. No participants dropped out of the study.

Results: Changes in IGF-I after alcohol detoxification showed a marked dimorphism in altered hepatic biochemistry upon admission, with a rise in those with normal liver enzymes upon admission (p = 0.016, Kruskall-Wallis) and a drop in those with elevated liver enzymes upon admission (p = 0.05); the latter was noted in subjects that had consumed alcohol close to the time of admission. Overall, however, IGF-I and IGFBP-3 were within normal limits for most subjects both upon admission and after alcohol detoxification; no significant differences were detected among the examined parameters in men vs. women, and there were no significant correlations of IGF-I, IGFBP-3 or the IGF-I/IGFBP-3 molar ratio with BMI or age.

Conclusions: Regardless of hepatic enzymes' elevation, alcohol detoxification had overall slight effects on IGF-I and IGFBP-3.

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Related in: MedlinePlus

IGFBP-3 levels vs. IGF-I levels in subjects with elevated hepatic enzymes upon admission (closed circles) and subjects with normal hepatic enzymes upon admission (open circles).
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f1-medscimonit-17-10-cr547: IGFBP-3 levels vs. IGF-I levels in subjects with elevated hepatic enzymes upon admission (closed circles) and subjects with normal hepatic enzymes upon admission (open circles).

Mentions: Overall IGF-I and IGFBP-3 were within normal limits for most subjects both upon admission and after alcohol detoxification; no significant differences were detected among the examined parameters in men vs. women; there were no significant differences in BMI in subjects with normal hepatic biochemistry vs. those with impaired hepatic biochemistry, and no significant correlations of IGF-I, IGFBP-3 or the IGF-I/IGFBP-3 molar ratio with BMI or age were found (data not shown). Furthermore, Spearman’s correlations that were run for IGFBP-3 vs. IGF-I levels using hepatic enzymes’ levels, timing of last drink before admission and timing of sampling as dummy variables did not reach statistical significance (Figure 1).


IGF-I and IGFBP-3 before and after inpatient alcohol detoxification in alcohol-dependent subjects.

Ilias I, Paparrigopoulos T, Tzavellas E, Karaiskos D, Kontoleon P, Liappas I - Med. Sci. Monit. (2011)

IGFBP-3 levels vs. IGF-I levels in subjects with elevated hepatic enzymes upon admission (closed circles) and subjects with normal hepatic enzymes upon admission (open circles).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3539473&req=5

f1-medscimonit-17-10-cr547: IGFBP-3 levels vs. IGF-I levels in subjects with elevated hepatic enzymes upon admission (closed circles) and subjects with normal hepatic enzymes upon admission (open circles).
Mentions: Overall IGF-I and IGFBP-3 were within normal limits for most subjects both upon admission and after alcohol detoxification; no significant differences were detected among the examined parameters in men vs. women; there were no significant differences in BMI in subjects with normal hepatic biochemistry vs. those with impaired hepatic biochemistry, and no significant correlations of IGF-I, IGFBP-3 or the IGF-I/IGFBP-3 molar ratio with BMI or age were found (data not shown). Furthermore, Spearman’s correlations that were run for IGFBP-3 vs. IGF-I levels using hepatic enzymes’ levels, timing of last drink before admission and timing of sampling as dummy variables did not reach statistical significance (Figure 1).

Bottom Line: No participants dropped out of the study.Overall, however, IGF-I and IGFBP-3 were within normal limits for most subjects both upon admission and after alcohol detoxification; no significant differences were detected among the examined parameters in men vs. women, and there were no significant correlations of IGF-I, IGFBP-3 or the IGF-I/IGFBP-3 molar ratio with BMI or age.Regardless of hepatic enzymes' elevation, alcohol detoxification had overall slight effects on IGF-I and IGFBP-3.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology, Diabetes and Metabolism, Elena Venizelou Hospital, Athens, Greece. iiliasmd@yahoo.com

ABSTRACT

Background: It is unclear whether alcohol detoxification has an effect on factors that are involved in growth, metabolic functions and cell proliferation. Alcohol abuse is associated with low IGF-I levels that tend to rise after alcohol withdrawal. There is a paucity of studies on the course of IGFBP-3 (the main binding protein for IGF-I) after alcohol detoxification.

Material/methods: We prospectively assessed IGF-I and IGFBP-3 changes at the time of admission and after 4 to 6 weeks of detoxification in an inpatient alcohol detoxification facility in 118 alcohol-dependent subjects given a regular hospital diet. No participants dropped out of the study.

Results: Changes in IGF-I after alcohol detoxification showed a marked dimorphism in altered hepatic biochemistry upon admission, with a rise in those with normal liver enzymes upon admission (p = 0.016, Kruskall-Wallis) and a drop in those with elevated liver enzymes upon admission (p = 0.05); the latter was noted in subjects that had consumed alcohol close to the time of admission. Overall, however, IGF-I and IGFBP-3 were within normal limits for most subjects both upon admission and after alcohol detoxification; no significant differences were detected among the examined parameters in men vs. women, and there were no significant correlations of IGF-I, IGFBP-3 or the IGF-I/IGFBP-3 molar ratio with BMI or age.

Conclusions: Regardless of hepatic enzymes' elevation, alcohol detoxification had overall slight effects on IGF-I and IGFBP-3.

Show MeSH
Related in: MedlinePlus