Limits...
Evaluation of differentiated neurotherapy programs for a patient after severe TBI and long term coma using event-related potentials.

Pachalska M, Łukowicz M, Kropotov JD, Herman-Sucharska I, Talar J - Med. Sci. Monit. (2011)

Bottom Line: As hypothesized, patient M.L-S showed small improvements in executive dysfunction and behavioral disorders after the conclusion of program A, and major improvement after program B.Similarly, in physiological changes the patient showed small improvement after relative beta training and a significant improvement of the P300 NOGO component after the rTMS program.A combination of different neurotherapeutical approaches (such as neurofeedback, rTMS, tDCS) can be suggested for similar severe cases of TBI.

View Article: PubMed Central - PubMed

Affiliation: Andrzej Frycz Modrzewski Cracow University, Cracow, Poland and Center for Cognition and Communication, New York, NY, USA. neuropsychologia23@o2.pl

ABSTRACT

Background: This article examines the effectiveness of differentiated rehabilitation programs for a patient with frontal syndrome after severe TBI and long-term coma. We hypothesized that there would be a small response to relative beta training, and a good response to rTMS, applied to regulate the dynamics of brain function.

Case report: M. L-S, age 26, suffered from anosognosia, executive dysfunction, and behavioral changes, after a skiing accident and prolonged coma, rendering him unable to function independently in many situations of everyday life. Only slight progress was made after traditional rehabilitation. The patient took part in 20 sessions of relative beta training (program A) and later in 20 sessions of rTMS (program B); both programs were combined with behavioral training. We used standardized neuropsychological testing, as well as ERPs before the experiment, after the completion of program A, and again after the completion of program B. As hypothesized, patient M.L-S showed small improvements in executive dysfunction and behavioral disorders after the conclusion of program A, and major improvement after program B. Similarly, in physiological changes the patient showed small improvement after relative beta training and a significant improvement of the P300 NOGO component after the rTMS program.

Conclusions: The rTMS program produced larger physiological and behavioral changes than did relative beta training. A combination of different neurotherapeutical approaches (such as neurofeedback, rTMS, tDCS) can be suggested for similar severe cases of TBI. ERPs can be used to assess functional brain changes induced by neurotherapeutical programs.

Show MeSH

Related in: MedlinePlus

ERP recordings in examination 1st, 2nd and 3rd in comparison to norm.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3539468&req=5

f9-medscimonit-17-10-cs120: ERP recordings in examination 1st, 2nd and 3rd in comparison to norm.

Mentions: It should stressed here that EEG spectra did not change significantly during the course of the two rehabilitation programs. In contrast, ERPs changed substantially after Program B. Figure 9 depicts the results of ERP recordings before treatment (first recording), after rehabilitation program A (second recording), and after rehabilitation program B (third recording). As one can see, the amplitude of spatial distribution of the NOGO ERPs differed for the corresponding parameters of healthy controls at the first recording. No visible changes occurred after rehabilitation program A. Large and statistically significant changes occurred after rehabilitation program B. It should be stressed, however, that even after substantial change in the course of program B, the NOGO ERPs in the patient were still much different from the norm.


Evaluation of differentiated neurotherapy programs for a patient after severe TBI and long term coma using event-related potentials.

Pachalska M, Łukowicz M, Kropotov JD, Herman-Sucharska I, Talar J - Med. Sci. Monit. (2011)

ERP recordings in examination 1st, 2nd and 3rd in comparison to norm.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3539468&req=5

f9-medscimonit-17-10-cs120: ERP recordings in examination 1st, 2nd and 3rd in comparison to norm.
Mentions: It should stressed here that EEG spectra did not change significantly during the course of the two rehabilitation programs. In contrast, ERPs changed substantially after Program B. Figure 9 depicts the results of ERP recordings before treatment (first recording), after rehabilitation program A (second recording), and after rehabilitation program B (third recording). As one can see, the amplitude of spatial distribution of the NOGO ERPs differed for the corresponding parameters of healthy controls at the first recording. No visible changes occurred after rehabilitation program A. Large and statistically significant changes occurred after rehabilitation program B. It should be stressed, however, that even after substantial change in the course of program B, the NOGO ERPs in the patient were still much different from the norm.

Bottom Line: As hypothesized, patient M.L-S showed small improvements in executive dysfunction and behavioral disorders after the conclusion of program A, and major improvement after program B.Similarly, in physiological changes the patient showed small improvement after relative beta training and a significant improvement of the P300 NOGO component after the rTMS program.A combination of different neurotherapeutical approaches (such as neurofeedback, rTMS, tDCS) can be suggested for similar severe cases of TBI.

View Article: PubMed Central - PubMed

Affiliation: Andrzej Frycz Modrzewski Cracow University, Cracow, Poland and Center for Cognition and Communication, New York, NY, USA. neuropsychologia23@o2.pl

ABSTRACT

Background: This article examines the effectiveness of differentiated rehabilitation programs for a patient with frontal syndrome after severe TBI and long-term coma. We hypothesized that there would be a small response to relative beta training, and a good response to rTMS, applied to regulate the dynamics of brain function.

Case report: M. L-S, age 26, suffered from anosognosia, executive dysfunction, and behavioral changes, after a skiing accident and prolonged coma, rendering him unable to function independently in many situations of everyday life. Only slight progress was made after traditional rehabilitation. The patient took part in 20 sessions of relative beta training (program A) and later in 20 sessions of rTMS (program B); both programs were combined with behavioral training. We used standardized neuropsychological testing, as well as ERPs before the experiment, after the completion of program A, and again after the completion of program B. As hypothesized, patient M.L-S showed small improvements in executive dysfunction and behavioral disorders after the conclusion of program A, and major improvement after program B. Similarly, in physiological changes the patient showed small improvement after relative beta training and a significant improvement of the P300 NOGO component after the rTMS program.

Conclusions: The rTMS program produced larger physiological and behavioral changes than did relative beta training. A combination of different neurotherapeutical approaches (such as neurofeedback, rTMS, tDCS) can be suggested for similar severe cases of TBI. ERPs can be used to assess functional brain changes induced by neurotherapeutical programs.

Show MeSH
Related in: MedlinePlus