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Involvement of the lymphatic system in salt-sensitive hypertension in humans.

Liu F, Mu J, Yuan Z, Lian Q, Zheng S, Wu G, Liu E - Med. Sci. Monit. (2011)

Bottom Line: High salt intake significantly increased the plasma VEGF-C level.The comparison of VEGF-C levels between the 2 groups had significant statistical difference (P<0.01).The VEGF-C level increases significantly in the salt-sensitive subjects after high salt intake.

View Article: PubMed Central - PubMed

Affiliation: Cardiovascular Department, 1st Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, PR China.

ABSTRACT

Background: The mechanisms of salt sensitivity as an important intermediate phenotype of essential hypertension remain elusive. A novel theory proposes that lymphatic vessels regulate sodium and fluid homeostasis. Since vascular endothelial growth factor C (VEGF-C) plays a vital role in lymphatic capillary hyperplasia, we hypothesized that VEGF-C was involved in salt-sensitive hypertension. We therefore investigated its plasma concentration in salt-sensitive subjects.

Material/methods: Twenty-seven subjects (BP ≤ 160/100 mmHg; age range 25-50 years) from a rural community of northern China were enrolled in this study. The baseline BP of volunteers was monitored for 3 days, followed by a low-salt diet for 7 days (3 g/day, NaCl) and a high-salt diet for 7 days (18 g/day, NaCl). Those who exhibited a BP increase of 10% from low-salt period to high-salt period were diagnosed as salt-sensitive subjects. The concentration of plasma VEGF-C was measured by an immunoenzyme method (ELISA).

Result: High salt intake significantly increased the plasma VEGF-C level. It was higher in the salt-sensitive subjects (3642.2 ± 406.1 pg/ml) than in the salt-resistant subjects (2249.8 ± 214.6 pg/ml). The comparison of VEGF-C levels between the 2 groups had significant statistical difference (P<0.01).

Conclusions: The VEGF-C level increases significantly in the salt-sensitive subjects after high salt intake. VEGF-C could be used as a biomarker of salt sensitivity.

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Related in: MedlinePlus

The plasma VEGF-C concentration in the salt sensitive and salt resistant subjects during low-salt and high-salt diet. * P<0.05 vs. low salt diet, #P<0.05 vs. SR group.
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f3-medscimonit-17-10-cr542: The plasma VEGF-C concentration in the salt sensitive and salt resistant subjects during low-salt and high-salt diet. * P<0.05 vs. low salt diet, #P<0.05 vs. SR group.

Mentions: As shown in Figure 3, the statistical difference was not significant in the plasma VEGF-C levels between the salt-sensitive subjects and the salt-resistant subjects during low salt intake (1921.1±238.2 μg/ml vs. 1804.2±206.4 μg/ml, P=0.59). However, the high salt intake clearly enhanced the plasma VEGF-C levels in both the salt-sensitive subjects (3642.2±406.1 μg/ml) and the salt-resistant subjects (2249.8±214.6 μg/ml). The increase was significantly higher in the salt-sensitive subjects than in the salt-resistant subjects (P=0.0038). Compared with the low salt intake, the salt-sensitive subjects had significantly increased plasma VEGF-C level after high salt intake (P<0.001). In contrast, the salt-resistant subjects did not show this trend (P=0.041). Moreover, there was no correlation between the plasma VEGF-C and BP (r=0.412, P=0.29).


Involvement of the lymphatic system in salt-sensitive hypertension in humans.

Liu F, Mu J, Yuan Z, Lian Q, Zheng S, Wu G, Liu E - Med. Sci. Monit. (2011)

The plasma VEGF-C concentration in the salt sensitive and salt resistant subjects during low-salt and high-salt diet. * P<0.05 vs. low salt diet, #P<0.05 vs. SR group.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3539464&req=5

f3-medscimonit-17-10-cr542: The plasma VEGF-C concentration in the salt sensitive and salt resistant subjects during low-salt and high-salt diet. * P<0.05 vs. low salt diet, #P<0.05 vs. SR group.
Mentions: As shown in Figure 3, the statistical difference was not significant in the plasma VEGF-C levels between the salt-sensitive subjects and the salt-resistant subjects during low salt intake (1921.1±238.2 μg/ml vs. 1804.2±206.4 μg/ml, P=0.59). However, the high salt intake clearly enhanced the plasma VEGF-C levels in both the salt-sensitive subjects (3642.2±406.1 μg/ml) and the salt-resistant subjects (2249.8±214.6 μg/ml). The increase was significantly higher in the salt-sensitive subjects than in the salt-resistant subjects (P=0.0038). Compared with the low salt intake, the salt-sensitive subjects had significantly increased plasma VEGF-C level after high salt intake (P<0.001). In contrast, the salt-resistant subjects did not show this trend (P=0.041). Moreover, there was no correlation between the plasma VEGF-C and BP (r=0.412, P=0.29).

Bottom Line: High salt intake significantly increased the plasma VEGF-C level.The comparison of VEGF-C levels between the 2 groups had significant statistical difference (P<0.01).The VEGF-C level increases significantly in the salt-sensitive subjects after high salt intake.

View Article: PubMed Central - PubMed

Affiliation: Cardiovascular Department, 1st Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, PR China.

ABSTRACT

Background: The mechanisms of salt sensitivity as an important intermediate phenotype of essential hypertension remain elusive. A novel theory proposes that lymphatic vessels regulate sodium and fluid homeostasis. Since vascular endothelial growth factor C (VEGF-C) plays a vital role in lymphatic capillary hyperplasia, we hypothesized that VEGF-C was involved in salt-sensitive hypertension. We therefore investigated its plasma concentration in salt-sensitive subjects.

Material/methods: Twenty-seven subjects (BP ≤ 160/100 mmHg; age range 25-50 years) from a rural community of northern China were enrolled in this study. The baseline BP of volunteers was monitored for 3 days, followed by a low-salt diet for 7 days (3 g/day, NaCl) and a high-salt diet for 7 days (18 g/day, NaCl). Those who exhibited a BP increase of 10% from low-salt period to high-salt period were diagnosed as salt-sensitive subjects. The concentration of plasma VEGF-C was measured by an immunoenzyme method (ELISA).

Result: High salt intake significantly increased the plasma VEGF-C level. It was higher in the salt-sensitive subjects (3642.2 ± 406.1 pg/ml) than in the salt-resistant subjects (2249.8 ± 214.6 pg/ml). The comparison of VEGF-C levels between the 2 groups had significant statistical difference (P<0.01).

Conclusions: The VEGF-C level increases significantly in the salt-sensitive subjects after high salt intake. VEGF-C could be used as a biomarker of salt sensitivity.

Show MeSH
Related in: MedlinePlus