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A case report of spindle cell (sarcomatoid) carcinoma of the larynx.

Boamah H, Ballard B - Case Rep Med (2012)

Bottom Line: Most spindle cell tumors are polypoid and pedunculated; they are often detected at an early stage, removed by polypectomy during diagnosis, and tend to have a very good prognosis.We present a case of spindle cell carcinoma in a 67-year-old Caucasian male who presented with progressive hoarseness of his voice, dysphagia, odynophagia and a 20-pound weight loss.His symptoms gradually improved, and he regained good control of his voice.

View Article: PubMed Central - PubMed

Affiliation: Meharry Medical College, 1005 DR DB Todd Boulevard, Nashville, TN 37208, USA.

ABSTRACT
Spindle cell carcinoma (SpCC) or sarcomatoid carcinoma is a highly malignant variant of squamous cell carcinoma which comprises 2% to 3% of all laryngeal cancers. It is considered to be a biphasic tumor that is composed of a squamous cell carcinoma (in situ or invasive) and spindle cell carcinoma with sarcomatous appearance. Most spindle cell tumors are polypoid and pedunculated; they are often detected at an early stage, removed by polypectomy during diagnosis, and tend to have a very good prognosis. We present a case of spindle cell carcinoma in a 67-year-old Caucasian male who presented with progressive hoarseness of his voice, dysphagia, odynophagia and a 20-pound weight loss. The patient underwent direct laryngoscopy with excision of the malignant mass and received radiation therapy. His symptoms gradually improved, and he regained good control of his voice.

No MeSH data available.


Related in: MedlinePlus

Immunohistochemistry: cytokeratin AE1/AE3, strongly positive diffuse nuclear staining of neoplastic cells, Ck 5/6, strongly positive nuclear cytoplasmic staining of neoplastic cells, vimentin, strongly positive. Epithelial membrane antigens (EMA) was positive.
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fig3: Immunohistochemistry: cytokeratin AE1/AE3, strongly positive diffuse nuclear staining of neoplastic cells, Ck 5/6, strongly positive nuclear cytoplasmic staining of neoplastic cells, vimentin, strongly positive. Epithelial membrane antigens (EMA) was positive.

Mentions: The pathology report showed a spindle cell (sarcomatoid) carcinoma (Figure 2) that strongly stained for EMA, CK 5/6 and AE 1/3, and a high MIB-1 but negative for myoD1, SMA, desmin, and myf4 (Figure 3).


A case report of spindle cell (sarcomatoid) carcinoma of the larynx.

Boamah H, Ballard B - Case Rep Med (2012)

Immunohistochemistry: cytokeratin AE1/AE3, strongly positive diffuse nuclear staining of neoplastic cells, Ck 5/6, strongly positive nuclear cytoplasmic staining of neoplastic cells, vimentin, strongly positive. Epithelial membrane antigens (EMA) was positive.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3539458&req=5

fig3: Immunohistochemistry: cytokeratin AE1/AE3, strongly positive diffuse nuclear staining of neoplastic cells, Ck 5/6, strongly positive nuclear cytoplasmic staining of neoplastic cells, vimentin, strongly positive. Epithelial membrane antigens (EMA) was positive.
Mentions: The pathology report showed a spindle cell (sarcomatoid) carcinoma (Figure 2) that strongly stained for EMA, CK 5/6 and AE 1/3, and a high MIB-1 but negative for myoD1, SMA, desmin, and myf4 (Figure 3).

Bottom Line: Most spindle cell tumors are polypoid and pedunculated; they are often detected at an early stage, removed by polypectomy during diagnosis, and tend to have a very good prognosis.We present a case of spindle cell carcinoma in a 67-year-old Caucasian male who presented with progressive hoarseness of his voice, dysphagia, odynophagia and a 20-pound weight loss.His symptoms gradually improved, and he regained good control of his voice.

View Article: PubMed Central - PubMed

Affiliation: Meharry Medical College, 1005 DR DB Todd Boulevard, Nashville, TN 37208, USA.

ABSTRACT
Spindle cell carcinoma (SpCC) or sarcomatoid carcinoma is a highly malignant variant of squamous cell carcinoma which comprises 2% to 3% of all laryngeal cancers. It is considered to be a biphasic tumor that is composed of a squamous cell carcinoma (in situ or invasive) and spindle cell carcinoma with sarcomatous appearance. Most spindle cell tumors are polypoid and pedunculated; they are often detected at an early stage, removed by polypectomy during diagnosis, and tend to have a very good prognosis. We present a case of spindle cell carcinoma in a 67-year-old Caucasian male who presented with progressive hoarseness of his voice, dysphagia, odynophagia and a 20-pound weight loss. The patient underwent direct laryngoscopy with excision of the malignant mass and received radiation therapy. His symptoms gradually improved, and he regained good control of his voice.

No MeSH data available.


Related in: MedlinePlus