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Levels of interferon-gamma increase after treatment for latent tuberculosis infection in a high-transmission setting.

Takenami I, Finkmoore B, Machado A, Emodi K, Riley LW, Arruda S - Pulm Med (2012)

Bottom Line: The IFN-γ response to Mycobacterium tuberculosis-specific antigens was measured, and the results before and after the completion of LTBI treatment were compared.Results.Conclusion.

View Article: PubMed Central - PubMed

Affiliation: Advanced Laboratory of Public Health, Oswaldo Cruz Foundation, Gonçalo Moniz Research Center, Salvador, Bahia 40296 710, Brazil.

ABSTRACT
Objectives. We investigated IFN-γ levels before and after a six month course of isoniazid among individuals with latent tuberculosis infection (LTBI) in a high-transmission setting. Design. A total of 26 household contacts of pulmonary tuberculosis patients who were positive for LTBI by tuberculin skin test completed six months of treatment and submitted a blood sample for a follow-up examination. The IFN-γ response to Mycobacterium tuberculosis-specific antigens was measured, and the results before and after the completion of LTBI treatment were compared. Results. Of the 26 study participants, 25 (96%) showed an IFN-γ level higher than their baseline level before treatment (P ≤ 0.001). Only one individual had a decreased IFN-γ level after treatment but remained positive for LTBI. Conclusion. In a high-transmission setting, the IFN-γ level has increased after LTBI treatment. Further studies must be undertaken to understand if this elevation is transient.

No MeSH data available.


Related in: MedlinePlus

The difference between the baseline and follow-up IGRA result according to the number of months elapsed between the completion of H treatment and the follow-up examination. IFN-γ levels were measured by QFT-IT and plotted for each study participant (n = 26). H = isoniazid; IFN-γ = interferon-gamma; QFT-IT = QuantiFERON TB Gold in Tube.
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Related In: Results  -  Collection


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fig1: The difference between the baseline and follow-up IGRA result according to the number of months elapsed between the completion of H treatment and the follow-up examination. IFN-γ levels were measured by QFT-IT and plotted for each study participant (n = 26). H = isoniazid; IFN-γ = interferon-gamma; QFT-IT = QuantiFERON TB Gold in Tube.

Mentions: Of the 101 HHC of pulmonary TB patients who tested positive for LTBI by TST and initiated on LTBI treatment between January 2007 and February 2008, 55 (54.5%) completed six months of therapy with H. Of the 55 HHC, 26 (47.3%) returned to HEOM for the follow-up examination and submitted a second blood sample for a second test. The second blood sample was submitted for follow-up examination between four and 14 months after the completion of LTBI treatment (Figure 1). None of the 26 HHC who returned for the follow-up examination sought medical attention at HEOM for symptoms consistent with TB between the time they concluded LTBI treatment and the follow-up examination.


Levels of interferon-gamma increase after treatment for latent tuberculosis infection in a high-transmission setting.

Takenami I, Finkmoore B, Machado A, Emodi K, Riley LW, Arruda S - Pulm Med (2012)

The difference between the baseline and follow-up IGRA result according to the number of months elapsed between the completion of H treatment and the follow-up examination. IFN-γ levels were measured by QFT-IT and plotted for each study participant (n = 26). H = isoniazid; IFN-γ = interferon-gamma; QFT-IT = QuantiFERON TB Gold in Tube.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3539439&req=5

fig1: The difference between the baseline and follow-up IGRA result according to the number of months elapsed between the completion of H treatment and the follow-up examination. IFN-γ levels were measured by QFT-IT and plotted for each study participant (n = 26). H = isoniazid; IFN-γ = interferon-gamma; QFT-IT = QuantiFERON TB Gold in Tube.
Mentions: Of the 101 HHC of pulmonary TB patients who tested positive for LTBI by TST and initiated on LTBI treatment between January 2007 and February 2008, 55 (54.5%) completed six months of therapy with H. Of the 55 HHC, 26 (47.3%) returned to HEOM for the follow-up examination and submitted a second blood sample for a second test. The second blood sample was submitted for follow-up examination between four and 14 months after the completion of LTBI treatment (Figure 1). None of the 26 HHC who returned for the follow-up examination sought medical attention at HEOM for symptoms consistent with TB between the time they concluded LTBI treatment and the follow-up examination.

Bottom Line: The IFN-γ response to Mycobacterium tuberculosis-specific antigens was measured, and the results before and after the completion of LTBI treatment were compared.Results.Conclusion.

View Article: PubMed Central - PubMed

Affiliation: Advanced Laboratory of Public Health, Oswaldo Cruz Foundation, Gonçalo Moniz Research Center, Salvador, Bahia 40296 710, Brazil.

ABSTRACT
Objectives. We investigated IFN-γ levels before and after a six month course of isoniazid among individuals with latent tuberculosis infection (LTBI) in a high-transmission setting. Design. A total of 26 household contacts of pulmonary tuberculosis patients who were positive for LTBI by tuberculin skin test completed six months of treatment and submitted a blood sample for a follow-up examination. The IFN-γ response to Mycobacterium tuberculosis-specific antigens was measured, and the results before and after the completion of LTBI treatment were compared. Results. Of the 26 study participants, 25 (96%) showed an IFN-γ level higher than their baseline level before treatment (P ≤ 0.001). Only one individual had a decreased IFN-γ level after treatment but remained positive for LTBI. Conclusion. In a high-transmission setting, the IFN-γ level has increased after LTBI treatment. Further studies must be undertaken to understand if this elevation is transient.

No MeSH data available.


Related in: MedlinePlus