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Modeling Airflow Using Subject-Specific 4DCT-Based Deformable Volumetric Lung Models.

Ilegbusi OJ, Li Z, Seyfi B, Min Y, Meeks S, Kupelian P, Santhanam AP - Int J Biomed Imaging (2012)

Bottom Line: A flow-structure interaction technique is employed that simultaneously models airflow and lung deformation.The results include the 3D anisotropic lung deformation for known airflow pattern inside the lungs.The effects of anisotropy are also presented on both the spatiotemporal volumetric lung displacement and the regional lung hysteresis.

View Article: PubMed Central - PubMed

Affiliation: Department of Mechanical Materials and Aerospace Engineering, University of Central Florida, Orlando, FL 32816, USA.

ABSTRACT
Lung radiotherapy is greatly benefitted when the tumor motion caused by breathing can be modeled. The aim of this paper is to present the importance of using anisotropic and subject-specific tissue elasticity for simulating the airflow inside the lungs. A computational-fluid-dynamics (CFD) based approach is presented to simulate airflow inside a subject-specific deformable lung for modeling lung tumor motion and the motion of the surrounding tissues during radiotherapy. A flow-structure interaction technique is employed that simultaneously models airflow and lung deformation. The lung is modeled as a poroelastic medium with subject-specific anisotropic poroelastic properties on a geometry, which was reconstructed from four-dimensional computed tomography (4DCT) scan datasets of humans with lung cancer. The results include the 3D anisotropic lung deformation for known airflow pattern inside the lungs. The effects of anisotropy are also presented on both the spatiotemporal volumetric lung displacement and the regional lung hysteresis.

No MeSH data available.


Related in: MedlinePlus

Predicted lung deformation with linear YM.
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Related In: Results  -  Collection


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fig7: Predicted lung deformation with linear YM.

Mentions: The predicted lung deformation simulated using the flow structure interaction at different breathing phases is plotted in Figures 7 and 8 for the linear and anisotropic YM cases, respectively. The upper part of each figure is a cut-off view to illustrate the evolution of selected layers from the initial state over the specified duration. Figure 7 shows that with linear elasticity, the layers expanded monotonically in all directions. On the other hand, Figure 8 shows that the case with anisotropic elasticity exhibits both directional deformation as well as expansion.


Modeling Airflow Using Subject-Specific 4DCT-Based Deformable Volumetric Lung Models.

Ilegbusi OJ, Li Z, Seyfi B, Min Y, Meeks S, Kupelian P, Santhanam AP - Int J Biomed Imaging (2012)

Predicted lung deformation with linear YM.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3539421&req=5

fig7: Predicted lung deformation with linear YM.
Mentions: The predicted lung deformation simulated using the flow structure interaction at different breathing phases is plotted in Figures 7 and 8 for the linear and anisotropic YM cases, respectively. The upper part of each figure is a cut-off view to illustrate the evolution of selected layers from the initial state over the specified duration. Figure 7 shows that with linear elasticity, the layers expanded monotonically in all directions. On the other hand, Figure 8 shows that the case with anisotropic elasticity exhibits both directional deformation as well as expansion.

Bottom Line: A flow-structure interaction technique is employed that simultaneously models airflow and lung deformation.The results include the 3D anisotropic lung deformation for known airflow pattern inside the lungs.The effects of anisotropy are also presented on both the spatiotemporal volumetric lung displacement and the regional lung hysteresis.

View Article: PubMed Central - PubMed

Affiliation: Department of Mechanical Materials and Aerospace Engineering, University of Central Florida, Orlando, FL 32816, USA.

ABSTRACT
Lung radiotherapy is greatly benefitted when the tumor motion caused by breathing can be modeled. The aim of this paper is to present the importance of using anisotropic and subject-specific tissue elasticity for simulating the airflow inside the lungs. A computational-fluid-dynamics (CFD) based approach is presented to simulate airflow inside a subject-specific deformable lung for modeling lung tumor motion and the motion of the surrounding tissues during radiotherapy. A flow-structure interaction technique is employed that simultaneously models airflow and lung deformation. The lung is modeled as a poroelastic medium with subject-specific anisotropic poroelastic properties on a geometry, which was reconstructed from four-dimensional computed tomography (4DCT) scan datasets of humans with lung cancer. The results include the 3D anisotropic lung deformation for known airflow pattern inside the lungs. The effects of anisotropy are also presented on both the spatiotemporal volumetric lung displacement and the regional lung hysteresis.

No MeSH data available.


Related in: MedlinePlus