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Beneficial Effects of Pentanema vestitum Linn. Whole Plant on the Glucose and Other Biochemical Parameters of Alloxan Induced Diabetic Rabbits.

Ilahi I, Asghar A, Ali S, Khan M, Khan N - ISRN Pharmacol (2012)

Bottom Line: The extract of Pentanema vestitum whole plant exhibited significant (P < 0.05) antihyperglycemic activity in glucose-induced hyperglycemic rabbits.During the study of lipid profile, the extract proved to be antihyperlipidemic and HDL boosting in diabetic rabbit models.From the finding of the present research, it was concluded that the 70% methanol extract of Pentanema vestitum whole plant has beneficial effects on serum levels of glucose, lipid profile, GPT, ALP, bilirubin, and creatinine of diabetic rabbits.

View Article: PubMed Central - PubMed

Affiliation: Department of Zoology, University of Malakand, Chakdara, Dir Lower 25000, Khyber Pakhtunkhwa, Pakistan.

ABSTRACT
The residents of Lower Dir and Malakand agency, Khyber Pakhtunkhwa, Pakistan, use the dry powder of whole plant of Pentanema vestitum for the treatment of asthma and diabetes. No documented reports are available about the therapeutic action of Pentanema vestitum. The present study was aimed to explore the antihyperglycemic effect of 70% methanol extract of Pentanema vestitum whole plant in glucose-induced nondiabetic hyperglycemic and alloxan-induced diabetic rabbits. During this study, the effects of plant extract on the serum lipid profile, GPT, ALP, bilirubin and creatinine of diabetic rabbits were also studied. The extract of Pentanema vestitum whole plant exhibited significant (P < 0.05) antihyperglycemic activity in glucose-induced hyperglycemic rabbits. Treatment of alloxan-induced diabetic rabbits with extract significantly (P < 0.05) reduced the elevated levels of serum glucose, GPT, ALP, bilirubin and creatinine. During the study of lipid profile, the extract proved to be antihyperlipidemic and HDL boosting in diabetic rabbit models. From the finding of the present research, it was concluded that the 70% methanol extract of Pentanema vestitum whole plant has beneficial effects on serum levels of glucose, lipid profile, GPT, ALP, bilirubin, and creatinine of diabetic rabbits.

No MeSH data available.


Related in: MedlinePlus

The effect of 70% methanol extract of Pentanema vestitum whole plant on the blood glucose level of glucose-induced nondiabetic hyperglycemic rabbits. Values are means and standard deviation of 5 replicates. Mean sharing a letter in common are not significantly different at P < 0.05. Means sharing no letter in common are significantly different at P < 0.05.
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Related In: Results  -  Collection


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fig1: The effect of 70% methanol extract of Pentanema vestitum whole plant on the blood glucose level of glucose-induced nondiabetic hyperglycemic rabbits. Values are means and standard deviation of 5 replicates. Mean sharing a letter in common are not significantly different at P < 0.05. Means sharing no letter in common are significantly different at P < 0.05.

Mentions: During the first phase of the present research, the anti-hyperglycemic effect of 70% methanol extracts of Pentenema vestitum whole plant was studied in glucose-induced nondiabetic hyperglycemic rabbits (Figure 1). During this study, at zero hour, there was no significant difference in the blood glucose levels of all groups (P > 0.05). After 1/2 hour of glucose load, there occurred extensive increase in the glucose levels of all the groups, however the mean glucose levels of the glibenclamide (305.2 ± 9.1 mg/dL) and the Pentenema vestitum extract-treated groups (294.2 ± 16.09 mg/dL) were non-significantly (P > 0.05) lower than the glucose-loaded control group (318.5 ± 18.12 mg/dL). After the 2nd hour of glucose load the level of glucose declined in all the groups in response to time. The mean glucose level of the glibenclamide (149 ± 11.4 mg/dL) and the extract-treated group (126.2 ± 6.2 mg/dL) was lower than that of the hyperglycemic control group (182.5 ± 1.7 mg/dL), and this time the difference was significant (P > 0.05). The plant extract and the drug glibenclamide were statistically homogeneous in antihyperglycemic activity (P > 0.05). After 3rd hour of glucose load the drug and the extract were still showing glucose-lowering activity. The blood glucose level of the drug (93 ± 11.95 mg/dL) and the extract-treated group (114.2 ± 12.91) was significantly lower than the hyperglycemic control group (135 ± 6.21 mg/dL) (P > 0.05). This time also the drug and the extract showed similar anti hyperglycemic effect (P > 0.05).


Beneficial Effects of Pentanema vestitum Linn. Whole Plant on the Glucose and Other Biochemical Parameters of Alloxan Induced Diabetic Rabbits.

Ilahi I, Asghar A, Ali S, Khan M, Khan N - ISRN Pharmacol (2012)

The effect of 70% methanol extract of Pentanema vestitum whole plant on the blood glucose level of glucose-induced nondiabetic hyperglycemic rabbits. Values are means and standard deviation of 5 replicates. Mean sharing a letter in common are not significantly different at P < 0.05. Means sharing no letter in common are significantly different at P < 0.05.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3539413&req=5

fig1: The effect of 70% methanol extract of Pentanema vestitum whole plant on the blood glucose level of glucose-induced nondiabetic hyperglycemic rabbits. Values are means and standard deviation of 5 replicates. Mean sharing a letter in common are not significantly different at P < 0.05. Means sharing no letter in common are significantly different at P < 0.05.
Mentions: During the first phase of the present research, the anti-hyperglycemic effect of 70% methanol extracts of Pentenema vestitum whole plant was studied in glucose-induced nondiabetic hyperglycemic rabbits (Figure 1). During this study, at zero hour, there was no significant difference in the blood glucose levels of all groups (P > 0.05). After 1/2 hour of glucose load, there occurred extensive increase in the glucose levels of all the groups, however the mean glucose levels of the glibenclamide (305.2 ± 9.1 mg/dL) and the Pentenema vestitum extract-treated groups (294.2 ± 16.09 mg/dL) were non-significantly (P > 0.05) lower than the glucose-loaded control group (318.5 ± 18.12 mg/dL). After the 2nd hour of glucose load the level of glucose declined in all the groups in response to time. The mean glucose level of the glibenclamide (149 ± 11.4 mg/dL) and the extract-treated group (126.2 ± 6.2 mg/dL) was lower than that of the hyperglycemic control group (182.5 ± 1.7 mg/dL), and this time the difference was significant (P > 0.05). The plant extract and the drug glibenclamide were statistically homogeneous in antihyperglycemic activity (P > 0.05). After 3rd hour of glucose load the drug and the extract were still showing glucose-lowering activity. The blood glucose level of the drug (93 ± 11.95 mg/dL) and the extract-treated group (114.2 ± 12.91) was significantly lower than the hyperglycemic control group (135 ± 6.21 mg/dL) (P > 0.05). This time also the drug and the extract showed similar anti hyperglycemic effect (P > 0.05).

Bottom Line: The extract of Pentanema vestitum whole plant exhibited significant (P < 0.05) antihyperglycemic activity in glucose-induced hyperglycemic rabbits.During the study of lipid profile, the extract proved to be antihyperlipidemic and HDL boosting in diabetic rabbit models.From the finding of the present research, it was concluded that the 70% methanol extract of Pentanema vestitum whole plant has beneficial effects on serum levels of glucose, lipid profile, GPT, ALP, bilirubin, and creatinine of diabetic rabbits.

View Article: PubMed Central - PubMed

Affiliation: Department of Zoology, University of Malakand, Chakdara, Dir Lower 25000, Khyber Pakhtunkhwa, Pakistan.

ABSTRACT
The residents of Lower Dir and Malakand agency, Khyber Pakhtunkhwa, Pakistan, use the dry powder of whole plant of Pentanema vestitum for the treatment of asthma and diabetes. No documented reports are available about the therapeutic action of Pentanema vestitum. The present study was aimed to explore the antihyperglycemic effect of 70% methanol extract of Pentanema vestitum whole plant in glucose-induced nondiabetic hyperglycemic and alloxan-induced diabetic rabbits. During this study, the effects of plant extract on the serum lipid profile, GPT, ALP, bilirubin and creatinine of diabetic rabbits were also studied. The extract of Pentanema vestitum whole plant exhibited significant (P < 0.05) antihyperglycemic activity in glucose-induced hyperglycemic rabbits. Treatment of alloxan-induced diabetic rabbits with extract significantly (P < 0.05) reduced the elevated levels of serum glucose, GPT, ALP, bilirubin and creatinine. During the study of lipid profile, the extract proved to be antihyperlipidemic and HDL boosting in diabetic rabbit models. From the finding of the present research, it was concluded that the 70% methanol extract of Pentanema vestitum whole plant has beneficial effects on serum levels of glucose, lipid profile, GPT, ALP, bilirubin, and creatinine of diabetic rabbits.

No MeSH data available.


Related in: MedlinePlus