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Primary uterine cervix schwannoma: a case report and review of the literature.

Tahmasbi M, Nguyen J, Ghayouri M, Shan Y, Hakam A - Case Rep Pathol (2012)

Bottom Line: Schwannoma (neurilemmoma) is a benign peripheral nerve sheath tumor that occurs in a wide variety of locations; however, its finding in the uterine cervix is extremely rare.In the English literature, a few cases of primary schwannoma of the cervix have been reported, which include seven cases of primary malignant cervical schwannoma and only two that are benign.These cases are reviewed in the following discussion.

View Article: PubMed Central - PubMed

Affiliation: Department of Anatomic Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA ; Department of Pathology and Cell Biology, University of South Florida, Tampa, FL 33612, USA.

ABSTRACT
Schwannoma (neurilemmoma) is a benign peripheral nerve sheath tumor that occurs in a wide variety of locations; however, its finding in the uterine cervix is extremely rare. We report a case of an incidental primary benign cervical schwannoma in a 48-year-old woman. In the English literature, a few cases of primary schwannoma of the cervix have been reported, which include seven cases of primary malignant cervical schwannoma and only two that are benign. These cases are reviewed in the following discussion.

No MeSH data available.


Related in: MedlinePlus

(a) Low-power view (2.5x) of the lesion showing a well-circumscribed mass with spindle cell proliferation and thick-wall hyalinized blood vessels. (b) Higher power view (10x) of the lesion. (c) Spindle cell component with strong S-100 immunoreactivity (10x). (d) Negative stain for NFP (10x).
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fig1: (a) Low-power view (2.5x) of the lesion showing a well-circumscribed mass with spindle cell proliferation and thick-wall hyalinized blood vessels. (b) Higher power view (10x) of the lesion. (c) Spindle cell component with strong S-100 immunoreactivity (10x). (d) Negative stain for NFP (10x).

Mentions: Histologically, the white rubbery nodule of the endocervical canal was a well circumscribed lesion composed of a spindle cell proliferation with localized nuclear palisading and abundant thick-wall hyalinized blood vessels (Figures 1(a) and 1(b)). Mitotic activity was minimal, which was confirmed with a scant Ki-67 staining pattern. Immunohistochemical stains with adequate controls showed strong immunoreactivity for S-100 (Figure 1(c)). However, the tumor cells were negative for NFP (neurofilament protein) (Figure 1(d)), CD34, desmin, actin, chromogranin, synaptophysin, and pan-melanoma. The combination of morphological and immunohistochemical features suggest a neoplasm of neural origin, specifically, schwannoma.


Primary uterine cervix schwannoma: a case report and review of the literature.

Tahmasbi M, Nguyen J, Ghayouri M, Shan Y, Hakam A - Case Rep Pathol (2012)

(a) Low-power view (2.5x) of the lesion showing a well-circumscribed mass with spindle cell proliferation and thick-wall hyalinized blood vessels. (b) Higher power view (10x) of the lesion. (c) Spindle cell component with strong S-100 immunoreactivity (10x). (d) Negative stain for NFP (10x).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3539385&req=5

fig1: (a) Low-power view (2.5x) of the lesion showing a well-circumscribed mass with spindle cell proliferation and thick-wall hyalinized blood vessels. (b) Higher power view (10x) of the lesion. (c) Spindle cell component with strong S-100 immunoreactivity (10x). (d) Negative stain for NFP (10x).
Mentions: Histologically, the white rubbery nodule of the endocervical canal was a well circumscribed lesion composed of a spindle cell proliferation with localized nuclear palisading and abundant thick-wall hyalinized blood vessels (Figures 1(a) and 1(b)). Mitotic activity was minimal, which was confirmed with a scant Ki-67 staining pattern. Immunohistochemical stains with adequate controls showed strong immunoreactivity for S-100 (Figure 1(c)). However, the tumor cells were negative for NFP (neurofilament protein) (Figure 1(d)), CD34, desmin, actin, chromogranin, synaptophysin, and pan-melanoma. The combination of morphological and immunohistochemical features suggest a neoplasm of neural origin, specifically, schwannoma.

Bottom Line: Schwannoma (neurilemmoma) is a benign peripheral nerve sheath tumor that occurs in a wide variety of locations; however, its finding in the uterine cervix is extremely rare.In the English literature, a few cases of primary schwannoma of the cervix have been reported, which include seven cases of primary malignant cervical schwannoma and only two that are benign.These cases are reviewed in the following discussion.

View Article: PubMed Central - PubMed

Affiliation: Department of Anatomic Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA ; Department of Pathology and Cell Biology, University of South Florida, Tampa, FL 33612, USA.

ABSTRACT
Schwannoma (neurilemmoma) is a benign peripheral nerve sheath tumor that occurs in a wide variety of locations; however, its finding in the uterine cervix is extremely rare. We report a case of an incidental primary benign cervical schwannoma in a 48-year-old woman. In the English literature, a few cases of primary schwannoma of the cervix have been reported, which include seven cases of primary malignant cervical schwannoma and only two that are benign. These cases are reviewed in the following discussion.

No MeSH data available.


Related in: MedlinePlus