Limits...
Skin reactions and quality of life after x-ray therapy of Basal cell carcinoma.

Skiveren J, Mikkelsen MR, Daugbjerg H, Wulf HC - J Skin Cancer (2012)

Bottom Line: Background.Results.Conclusions.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Copenhagen University Hospital, Bispebjerg Hospital, Copenhagen 2400, Denmark.

ABSTRACT
Background. Advanced basal cell carcinoma (BCC) is often treated by surgery or X-ray therapy. The consequences of X-ray therapy on the patients' health-related quality-of-life (HRQOL) have so far not been described. Objectives. To quantify quality of life in BCC patients before and after X-ray therapy compared with matched healthy controls. Materials. Twenty-five patients (mean age 69) with BCC completed the Dermatology Life Quality Index (DLQI) before and two weeks and three months after X-ray therapy and their results were compared with the DLQI scores for 25 matched controls. Results. Compared to the healthy controls the patients' DLQI score was significantly higher before and 2 weeks after X-ray therapy (P = 0.005; P = 0.000). The patients' DLQI score decreased significantly from baseline to three months after X-ray therapy (P = 0.024), when it became similar to that of the healthy controls (P = 0.819). Three months after X-ray therapy eight patients had no skin reactions, 11 had slight atrophy, pigmentation change, and/or some hair loss, four had patch atrophy, moderate telangiectasia, and/or total hair loss. Conclusions. BCC has a negative effect on patients' quality of life. The study shows that HRQOL normalises shortly after X-ray therapy, despite minor skin manifestations.

No MeSH data available.


Related in: MedlinePlus

Percentages of patients with ulcerative BCC at baseline (immediately before X-ray therapy), and radiotherapy induced ulcerations at different time points after completed X-ray therapy (n = 25).
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3539380&req=5

fig1: Percentages of patients with ulcerative BCC at baseline (immediately before X-ray therapy), and radiotherapy induced ulcerations at different time points after completed X-ray therapy (n = 25).

Mentions: HRQOL is considered an important outcome in cancer research, and is associated with sequela such as depression, anxiety, and vulnerability [8]. Although BCC is not life-threatening, it may affect HRQOL, because BCC often results in skin changes and ulcerations after X-ray therapy and may result in recognition of illness (Figure 1) [5, 6].


Skin reactions and quality of life after x-ray therapy of Basal cell carcinoma.

Skiveren J, Mikkelsen MR, Daugbjerg H, Wulf HC - J Skin Cancer (2012)

Percentages of patients with ulcerative BCC at baseline (immediately before X-ray therapy), and radiotherapy induced ulcerations at different time points after completed X-ray therapy (n = 25).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3539380&req=5

fig1: Percentages of patients with ulcerative BCC at baseline (immediately before X-ray therapy), and radiotherapy induced ulcerations at different time points after completed X-ray therapy (n = 25).
Mentions: HRQOL is considered an important outcome in cancer research, and is associated with sequela such as depression, anxiety, and vulnerability [8]. Although BCC is not life-threatening, it may affect HRQOL, because BCC often results in skin changes and ulcerations after X-ray therapy and may result in recognition of illness (Figure 1) [5, 6].

Bottom Line: Background.Results.Conclusions.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Copenhagen University Hospital, Bispebjerg Hospital, Copenhagen 2400, Denmark.

ABSTRACT
Background. Advanced basal cell carcinoma (BCC) is often treated by surgery or X-ray therapy. The consequences of X-ray therapy on the patients' health-related quality-of-life (HRQOL) have so far not been described. Objectives. To quantify quality of life in BCC patients before and after X-ray therapy compared with matched healthy controls. Materials. Twenty-five patients (mean age 69) with BCC completed the Dermatology Life Quality Index (DLQI) before and two weeks and three months after X-ray therapy and their results were compared with the DLQI scores for 25 matched controls. Results. Compared to the healthy controls the patients' DLQI score was significantly higher before and 2 weeks after X-ray therapy (P = 0.005; P = 0.000). The patients' DLQI score decreased significantly from baseline to three months after X-ray therapy (P = 0.024), when it became similar to that of the healthy controls (P = 0.819). Three months after X-ray therapy eight patients had no skin reactions, 11 had slight atrophy, pigmentation change, and/or some hair loss, four had patch atrophy, moderate telangiectasia, and/or total hair loss. Conclusions. BCC has a negative effect on patients' quality of life. The study shows that HRQOL normalises shortly after X-ray therapy, despite minor skin manifestations.

No MeSH data available.


Related in: MedlinePlus