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Melanocyte colonization and pigmentation of breast carcinoma: pathological and clinical aspects.

Mele M, Laurberg T, Engberg Damsgaard T, Funder J, Jensen V - Case Rep Pathol (2012)

Bottom Line: Discussion.The pathogenesis by which melanocyte migration takes place is not known, but a breached basement membrane is considered essential.Conclusion.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrine and Breast Surgery, Aarhus University Hospital, Tage Hansens Gade 2, 8000 Aarhus C, Denmark.

ABSTRACT
Introduction. Melanocyte colonization of breast carcinoma by nonneoplastic melanocytes of epidermal origin is a rare and serious condition first described in 1977. We report on the exceptional clinical and pathological features of this migration phenomenon in a 74-year-old patient. Discussion. The pathogenesis by which melanocyte migration takes place is not known, but a breached basement membrane is considered essential. Conclusion. Histological examination and additional staining of skin are essential to differentiate breast cancer melanosis from malignant melanoma.

No MeSH data available.


Related in: MedlinePlus

(a) Melanocytes colonizing the underlying carcinoma cells. (HE × 40). (b) Carcinoma cells surrounded by melan-A-positive melanocytes (×40). (c) Estrogen receptor positive carcinoma cells (×20).
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fig2: (a) Melanocytes colonizing the underlying carcinoma cells. (HE × 40). (b) Carcinoma cells surrounded by melan-A-positive melanocytes (×40). (c) Estrogen receptor positive carcinoma cells (×20).

Mentions: Massive vascular tumor embolisation was seen in the entire mammary tissue including the dermis. In several locations, the adenocarcinoma cells had infiltrated the superficial dermal connective tissue and penetrated the dermoepidermal junction (Figure 2(a)). At these specific areas, abundant melanin pigment was observed in elongated and dendritic melanocytes colonizing the underlying carcinoma cells.


Melanocyte colonization and pigmentation of breast carcinoma: pathological and clinical aspects.

Mele M, Laurberg T, Engberg Damsgaard T, Funder J, Jensen V - Case Rep Pathol (2012)

(a) Melanocytes colonizing the underlying carcinoma cells. (HE × 40). (b) Carcinoma cells surrounded by melan-A-positive melanocytes (×40). (c) Estrogen receptor positive carcinoma cells (×20).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3539375&req=5

fig2: (a) Melanocytes colonizing the underlying carcinoma cells. (HE × 40). (b) Carcinoma cells surrounded by melan-A-positive melanocytes (×40). (c) Estrogen receptor positive carcinoma cells (×20).
Mentions: Massive vascular tumor embolisation was seen in the entire mammary tissue including the dermis. In several locations, the adenocarcinoma cells had infiltrated the superficial dermal connective tissue and penetrated the dermoepidermal junction (Figure 2(a)). At these specific areas, abundant melanin pigment was observed in elongated and dendritic melanocytes colonizing the underlying carcinoma cells.

Bottom Line: Discussion.The pathogenesis by which melanocyte migration takes place is not known, but a breached basement membrane is considered essential.Conclusion.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrine and Breast Surgery, Aarhus University Hospital, Tage Hansens Gade 2, 8000 Aarhus C, Denmark.

ABSTRACT
Introduction. Melanocyte colonization of breast carcinoma by nonneoplastic melanocytes of epidermal origin is a rare and serious condition first described in 1977. We report on the exceptional clinical and pathological features of this migration phenomenon in a 74-year-old patient. Discussion. The pathogenesis by which melanocyte migration takes place is not known, but a breached basement membrane is considered essential. Conclusion. Histological examination and additional staining of skin are essential to differentiate breast cancer melanosis from malignant melanoma.

No MeSH data available.


Related in: MedlinePlus