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Melanocyte colonization and pigmentation of breast carcinoma: pathological and clinical aspects.

Mele M, Laurberg T, Engberg Damsgaard T, Funder J, Jensen V - Case Rep Pathol (2012)

Bottom Line: Discussion.The pathogenesis by which melanocyte migration takes place is not known, but a breached basement membrane is considered essential.Conclusion.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrine and Breast Surgery, Aarhus University Hospital, Tage Hansens Gade 2, 8000 Aarhus C, Denmark.

ABSTRACT
Introduction. Melanocyte colonization of breast carcinoma by nonneoplastic melanocytes of epidermal origin is a rare and serious condition first described in 1977. We report on the exceptional clinical and pathological features of this migration phenomenon in a 74-year-old patient. Discussion. The pathogenesis by which melanocyte migration takes place is not known, but a breached basement membrane is considered essential. Conclusion. Histological examination and additional staining of skin are essential to differentiate breast cancer melanosis from malignant melanoma.

No MeSH data available.


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(a) Large numbers of pigmented areas on the skin of the affected breast. (b) Pigmented maculae.
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fig1: (a) Large numbers of pigmented areas on the skin of the affected breast. (b) Pigmented maculae.

Mentions: The histological examination after core needle biopsy showed an estrogen receptor positive carcinoma. The patient was initially treated with Letrozole. This treatment induced partial regression of the tumor and metastases. In April 2010 she developed large numbers of heavily pigmented areas on the skin of the affected breast mimicking malignant melanoma, and she was referred to the Department of Plastic Surgery (Figure 1(a)).


Melanocyte colonization and pigmentation of breast carcinoma: pathological and clinical aspects.

Mele M, Laurberg T, Engberg Damsgaard T, Funder J, Jensen V - Case Rep Pathol (2012)

(a) Large numbers of pigmented areas on the skin of the affected breast. (b) Pigmented maculae.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3539375&req=5

fig1: (a) Large numbers of pigmented areas on the skin of the affected breast. (b) Pigmented maculae.
Mentions: The histological examination after core needle biopsy showed an estrogen receptor positive carcinoma. The patient was initially treated with Letrozole. This treatment induced partial regression of the tumor and metastases. In April 2010 she developed large numbers of heavily pigmented areas on the skin of the affected breast mimicking malignant melanoma, and she was referred to the Department of Plastic Surgery (Figure 1(a)).

Bottom Line: Discussion.The pathogenesis by which melanocyte migration takes place is not known, but a breached basement membrane is considered essential.Conclusion.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrine and Breast Surgery, Aarhus University Hospital, Tage Hansens Gade 2, 8000 Aarhus C, Denmark.

ABSTRACT
Introduction. Melanocyte colonization of breast carcinoma by nonneoplastic melanocytes of epidermal origin is a rare and serious condition first described in 1977. We report on the exceptional clinical and pathological features of this migration phenomenon in a 74-year-old patient. Discussion. The pathogenesis by which melanocyte migration takes place is not known, but a breached basement membrane is considered essential. Conclusion. Histological examination and additional staining of skin are essential to differentiate breast cancer melanosis from malignant melanoma.

No MeSH data available.


Related in: MedlinePlus