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Beta-Thalassemia in Iran: new insight into the role of genetic admixture and migration.

Rezaee AR, Banoei MM, Khalili E, Houshmand M - ScientificWorldJournal (2012)

Bottom Line: The Iranian population consists of multiethnic groups that have been influenced by various invasions and migration throughout history.We compared the frequencies of β-globin mutations in different regions of Iran with those derived from neighboring countries.The analysis provided evidence of complementary information about the genetic admixture and migration of some mutations, as well as the remarkable genetic classification of the Iranian people and ethnic groups.

View Article: PubMed Central - PubMed

Affiliation: Department of Animal Science, Faculty of Agriculture, Ferdowsi University of Mashhad, Mashhad, Iran.

ABSTRACT
Iran with an area of 1.648 million km(2) is located between the Caspian Sea and the Persian Gulf. The Iranian population consists of multiethnic groups that have been influenced by various invasions and migration throughout history. Studies have revealed the presence of more than 47 different β-globin gene mutations responsible for β-Thalassemia in Iran. This paper is an attempt to study the origin of β-Thalassemia mutations in different parts of Iran. Distribution of β-Thalassemia mutations in Iran shows different patterns in different areas. β-Thalassemia mutations have been a reflection of people and area in correlation with migration and origin of ancestors. We compared the frequencies of β-globin mutations in different regions of Iran with those derived from neighboring countries. The analysis provided evidence of complementary information about the genetic admixture and migration of some mutations, as well as the remarkable genetic classification of the Iranian people and ethnic groups.

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Related in: MedlinePlus

Distribution pattern of different mutations of β-Thalassemia in 21 provinces of Iran.
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Related In: Results  -  Collection


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fig1: Distribution pattern of different mutations of β-Thalassemia in 21 provinces of Iran.

Mentions: Among the eastern Mediterranean region, Iran is one of the major centers for the prevalence of β-Thalassemia. Regarding to high consanguinity among population, it is estimated that there are between two and three million β-Thalassemia carriers and 25,000 patients in Iran. Like many other countries in the region, a large number of Thalassemia patients are β-Thalassemia [7]. Alpha Thalassemia is not as prevalent as β-Thalassemia in Iran [8]. The gene frequency of β-Thalassemia, however, is high and varies considerably between areas. Recent studies have revealed the presence of more than 47 different β-globin gene mutations responsible for β-Thalassemia in Iran. The predominant IVS-II-1 (G > A; beta0) mutation is followed by decreasing order of frequency by the IVS-I-5 (G > C, beta+), the codons 8/9 (+G, beta0), the IVS-I-110 (G > A, beta+), the IVS-I-1 (G > A, beta0), 25 bp deletion (beta0), the IVS-I-6 (T > C, beta+), the codon 5 (-CT, beta0), and codon 39 (C > T, beta0) mutations. This group of mutations covers more than 85% of the total β-Thalassemia defects present in Iran [6, 9]. We compared β-Thalassemia mutations based on geographical area and frequency of mutation. Distribution of β-Thalassemia mutations in Iran shows different pattern in different area. In general, β-Thalassemia mutations have been a reflection of people and area in correlation with migration and origin of ancestors. We evaluated nine regions (A, B, C,…, I) which cover all of throughout Iran. Molecular screening revealed distribution pattern of different mutations of β-Thalassemia in 21 provinces (Figure 1, Table 1).


Beta-Thalassemia in Iran: new insight into the role of genetic admixture and migration.

Rezaee AR, Banoei MM, Khalili E, Houshmand M - ScientificWorldJournal (2012)

Distribution pattern of different mutations of β-Thalassemia in 21 provinces of Iran.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3539370&req=5

fig1: Distribution pattern of different mutations of β-Thalassemia in 21 provinces of Iran.
Mentions: Among the eastern Mediterranean region, Iran is one of the major centers for the prevalence of β-Thalassemia. Regarding to high consanguinity among population, it is estimated that there are between two and three million β-Thalassemia carriers and 25,000 patients in Iran. Like many other countries in the region, a large number of Thalassemia patients are β-Thalassemia [7]. Alpha Thalassemia is not as prevalent as β-Thalassemia in Iran [8]. The gene frequency of β-Thalassemia, however, is high and varies considerably between areas. Recent studies have revealed the presence of more than 47 different β-globin gene mutations responsible for β-Thalassemia in Iran. The predominant IVS-II-1 (G > A; beta0) mutation is followed by decreasing order of frequency by the IVS-I-5 (G > C, beta+), the codons 8/9 (+G, beta0), the IVS-I-110 (G > A, beta+), the IVS-I-1 (G > A, beta0), 25 bp deletion (beta0), the IVS-I-6 (T > C, beta+), the codon 5 (-CT, beta0), and codon 39 (C > T, beta0) mutations. This group of mutations covers more than 85% of the total β-Thalassemia defects present in Iran [6, 9]. We compared β-Thalassemia mutations based on geographical area and frequency of mutation. Distribution of β-Thalassemia mutations in Iran shows different pattern in different area. In general, β-Thalassemia mutations have been a reflection of people and area in correlation with migration and origin of ancestors. We evaluated nine regions (A, B, C,…, I) which cover all of throughout Iran. Molecular screening revealed distribution pattern of different mutations of β-Thalassemia in 21 provinces (Figure 1, Table 1).

Bottom Line: The Iranian population consists of multiethnic groups that have been influenced by various invasions and migration throughout history.We compared the frequencies of β-globin mutations in different regions of Iran with those derived from neighboring countries.The analysis provided evidence of complementary information about the genetic admixture and migration of some mutations, as well as the remarkable genetic classification of the Iranian people and ethnic groups.

View Article: PubMed Central - PubMed

Affiliation: Department of Animal Science, Faculty of Agriculture, Ferdowsi University of Mashhad, Mashhad, Iran.

ABSTRACT
Iran with an area of 1.648 million km(2) is located between the Caspian Sea and the Persian Gulf. The Iranian population consists of multiethnic groups that have been influenced by various invasions and migration throughout history. Studies have revealed the presence of more than 47 different β-globin gene mutations responsible for β-Thalassemia in Iran. This paper is an attempt to study the origin of β-Thalassemia mutations in different parts of Iran. Distribution of β-Thalassemia mutations in Iran shows different patterns in different areas. β-Thalassemia mutations have been a reflection of people and area in correlation with migration and origin of ancestors. We compared the frequencies of β-globin mutations in different regions of Iran with those derived from neighboring countries. The analysis provided evidence of complementary information about the genetic admixture and migration of some mutations, as well as the remarkable genetic classification of the Iranian people and ethnic groups.

Show MeSH
Related in: MedlinePlus