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Coffee Consumption and Stroke Risk: A Meta-analysis of Epidemiologic Studies.

Kim B, Nam Y, Kim J, Choi H, Won C - Korean J Fam Med (2012)

Bottom Line: The search was limited to English language.When subgroup analysis was performed, for Europeans, increased coffee drinking showed a preventive effect on stroke occurrence with RR 0.82 (95% CI, 0.74 to 0.92); RR for women 0.81 (95% CI, 0.70 to 0.93); for ischemic stroke 0.80 (95% CI, 0.71 to 0.90); and for those drinking 4 cups or more per day 0.83 (95% CI, 0.75 to 0.91).We found that coffee consumption of 4 cups or more per day showed a preventive effect on stroke in this meta-analysis.

View Article: PubMed Central - PubMed

Affiliation: Department of Family Medicine, Kyung Hee University School of Medicine, Seoul, Korea.

ABSTRACT

Background: Coffee is one of the most widely consumed beverages in the world, and contains caffeine and phenolic compounds. Many studies on the association between coffee consumption and risk of stroke have been reported, however, more research is needed to further explore many studies' inconsistent results. Therefore, we conducted a meta-analysis to verify the relationship between coffee consumption and stroke.

Methods: We searched MEDLINE (PubMed), EMBASE, and the Cochrane Library, using the keywords "coffee" or "caffeine" for the exposure factors, and "transient ischemic attack" or "stroke" or "acute cerebral infarction" or "cardiovascular events" for the outcome factors. We included prospective cohort and case-control studies published between 2001 and July 2011 in this review. The search was limited to English language.

Results: Among 27 articles identified for this review, only 9 studies met the inclusion criteria, all of which were cohort studies. When using all cohort studies, the pooled relative risk (RR) of stroke for the highest vs. lowest category of coffee consumption was 0.83 (95% confidence interval [CI], 0.76 to 0.91). When subgroup analysis was performed, for Europeans, increased coffee drinking showed a preventive effect on stroke occurrence with RR 0.82 (95% CI, 0.74 to 0.92); RR for women 0.81 (95% CI, 0.70 to 0.93); for ischemic stroke 0.80 (95% CI, 0.71 to 0.90); and for those drinking 4 cups or more per day 0.83 (95% CI, 0.75 to 0.91).

Conclusion: We found that coffee consumption of 4 cups or more per day showed a preventive effect on stroke in this meta-analysis.

No MeSH data available.


Related in: MedlinePlus

Coffee consumption and stroke risk in a subgroup analysis of women groups (n = 3). RR: relative risk, CI: confidence interval.
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Figure 3: Coffee consumption and stroke risk in a subgroup analysis of women groups (n = 3). RR: relative risk, CI: confidence interval.

Mentions: Thirdly, analysis was conducted by subgroups. With the exclusion of one paper12) that only investigated men, 5 studies that investigated both women and men and 3 studies that only investigated women were selected for analysis. Studies that included both sexes were unable to demonstrate a statistically significant association (RR, 1.02; 95% CI, 0.83 to 1.26), while the ones that included only the female sex showed a prophylactic effect on the development of stroke exclusively in the group with high coffee intake (RR, 0.81; 95% CI, 0.70 to 0.93) (Figure 3).


Coffee Consumption and Stroke Risk: A Meta-analysis of Epidemiologic Studies.

Kim B, Nam Y, Kim J, Choi H, Won C - Korean J Fam Med (2012)

Coffee consumption and stroke risk in a subgroup analysis of women groups (n = 3). RR: relative risk, CI: confidence interval.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3526718&req=5

Figure 3: Coffee consumption and stroke risk in a subgroup analysis of women groups (n = 3). RR: relative risk, CI: confidence interval.
Mentions: Thirdly, analysis was conducted by subgroups. With the exclusion of one paper12) that only investigated men, 5 studies that investigated both women and men and 3 studies that only investigated women were selected for analysis. Studies that included both sexes were unable to demonstrate a statistically significant association (RR, 1.02; 95% CI, 0.83 to 1.26), while the ones that included only the female sex showed a prophylactic effect on the development of stroke exclusively in the group with high coffee intake (RR, 0.81; 95% CI, 0.70 to 0.93) (Figure 3).

Bottom Line: The search was limited to English language.When subgroup analysis was performed, for Europeans, increased coffee drinking showed a preventive effect on stroke occurrence with RR 0.82 (95% CI, 0.74 to 0.92); RR for women 0.81 (95% CI, 0.70 to 0.93); for ischemic stroke 0.80 (95% CI, 0.71 to 0.90); and for those drinking 4 cups or more per day 0.83 (95% CI, 0.75 to 0.91).We found that coffee consumption of 4 cups or more per day showed a preventive effect on stroke in this meta-analysis.

View Article: PubMed Central - PubMed

Affiliation: Department of Family Medicine, Kyung Hee University School of Medicine, Seoul, Korea.

ABSTRACT

Background: Coffee is one of the most widely consumed beverages in the world, and contains caffeine and phenolic compounds. Many studies on the association between coffee consumption and risk of stroke have been reported, however, more research is needed to further explore many studies' inconsistent results. Therefore, we conducted a meta-analysis to verify the relationship between coffee consumption and stroke.

Methods: We searched MEDLINE (PubMed), EMBASE, and the Cochrane Library, using the keywords "coffee" or "caffeine" for the exposure factors, and "transient ischemic attack" or "stroke" or "acute cerebral infarction" or "cardiovascular events" for the outcome factors. We included prospective cohort and case-control studies published between 2001 and July 2011 in this review. The search was limited to English language.

Results: Among 27 articles identified for this review, only 9 studies met the inclusion criteria, all of which were cohort studies. When using all cohort studies, the pooled relative risk (RR) of stroke for the highest vs. lowest category of coffee consumption was 0.83 (95% confidence interval [CI], 0.76 to 0.91). When subgroup analysis was performed, for Europeans, increased coffee drinking showed a preventive effect on stroke occurrence with RR 0.82 (95% CI, 0.74 to 0.92); RR for women 0.81 (95% CI, 0.70 to 0.93); for ischemic stroke 0.80 (95% CI, 0.71 to 0.90); and for those drinking 4 cups or more per day 0.83 (95% CI, 0.75 to 0.91).

Conclusion: We found that coffee consumption of 4 cups or more per day showed a preventive effect on stroke in this meta-analysis.

No MeSH data available.


Related in: MedlinePlus