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CYP1A2 rs762551 polymorphism contributes to cancer susceptibility: a meta-analysis from 19 case-control studies.

Wang H, Zhang Z, Han S, Lu Y, Feng F, Yuan J - BMC Cancer (2012)

Bottom Line: The leave-one-out sensitivity analysis was conducted to determine whether our assumptions or decisions have a major effect on the results of the review.In subgroup analysis based on ethnicity, the rs762551CC genotype was associated with increased cancer risk (OR = 1.29, 95% CI = 1.27-1.63 in co-dominate model and OR = 1.17, 95% CI = 1.02-1.34 in dominant model in Caucasians, but not in Asians and the mixed population.These results suggested that CYP1A2 rs762551 polymorphism is likely to be associated with susceptibility to cancer in Caucasians.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Epidemiology, College of Public Health, Hebei United University, Tangshan 063000, China.

ABSTRACT

Background: Genetic polymorphism (rs762551A>C) in gene encoding cytochrome P450 1A2 (CYP1A2) has been shown to influence the inducibility of CYP1A2 expression and thus might be associated with risk of several types of human cancer. However, the results of previous studies on the associations of this polymorphism with risk of cancer are not all consistent. To clarify the potential contribution of CYP1A2 rs762551 to cancer risk, we performed a meta-analysis of the published case-control studies.

Methods: We used PubMed, Embase, OVID, ScienceDirect, and Chinese National Knowledge Infrastructure databases to identify the related publications for this meta-analysis. The pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using random effect model to evaluate the association of rs762551 with cancer risk. A χ(2)-based Q-test was used to examine the heterogeneity assumption and the funnel plot and Egger's test were used to examine the potential publication bias. The leave-one-out sensitivity analysis was conducted to determine whether our assumptions or decisions have a major effect on the results of the review.

Results: Our analysis of 19 eligible case-control studies showed a significant association between rs762551C variant with risk of cancer in the genetic model of CC versus AA (OR = 1.30, 95% CI = 1.02-1.64) and the dominant model (OR = 1.19, 95% CI = 1.04-1.36). In subgroup analysis based on ethnicity, the rs762551CC genotype was associated with increased cancer risk (OR = 1.29, 95% CI = 1.27-1.63 in co-dominate model and OR = 1.17, 95% CI = 1.02-1.34 in dominant model in Caucasians, but not in Asians and the mixed population.

Conclusion: These results suggested that CYP1A2 rs762551 polymorphism is likely to be associated with susceptibility to cancer in Caucasians.

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Related in: MedlinePlus

Forest plot of cancer risk associated with CYP1A2 rs762551 polymorphism in different ethnicity. Pooled odds ratio (OR) for (1) total samples, (2) Caucasians ethnicity, and (3) Asians ethnicity. The genetic models are CC versus AA. The squares and horizontal lines correspond to the study-specific odds ratio (OR) and 95% confidence interval (CI).
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Figure 2: Forest plot of cancer risk associated with CYP1A2 rs762551 polymorphism in different ethnicity. Pooled odds ratio (OR) for (1) total samples, (2) Caucasians ethnicity, and (3) Asians ethnicity. The genetic models are CC versus AA. The squares and horizontal lines correspond to the study-specific odds ratio (OR) and 95% confidence interval (CI).

Mentions: Regarding CYP1A2 rs762551 polymorphism, the eligible studies involved in 8218 cases and 11165 controls. For each study, we investigated the association based on the assumption of different inheritance models of CYP1A2 rs762551 A>C polymorphism. In all inheritance models of rs762551 polymorphism, due to the between-study heterogeneity in the individual studies (all P for Q test < 0.01 and I2>25%), the random-effect model was used to analyze the data[42]. We identified that rs762551 polymorphism had a weak correlation with the risk of cancer (CC versus AA, OR = 1.30, 95% CI = 1.02-1.64; dominant model, OR = 1.19, 95% CI = 1.04-1.36), but not in recessive model (OR = 1.19, 95% CI = 0.99-1.44) (Figure2 and Table2).


CYP1A2 rs762551 polymorphism contributes to cancer susceptibility: a meta-analysis from 19 case-control studies.

Wang H, Zhang Z, Han S, Lu Y, Feng F, Yuan J - BMC Cancer (2012)

Forest plot of cancer risk associated with CYP1A2 rs762551 polymorphism in different ethnicity. Pooled odds ratio (OR) for (1) total samples, (2) Caucasians ethnicity, and (3) Asians ethnicity. The genetic models are CC versus AA. The squares and horizontal lines correspond to the study-specific odds ratio (OR) and 95% confidence interval (CI).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3526566&req=5

Figure 2: Forest plot of cancer risk associated with CYP1A2 rs762551 polymorphism in different ethnicity. Pooled odds ratio (OR) for (1) total samples, (2) Caucasians ethnicity, and (3) Asians ethnicity. The genetic models are CC versus AA. The squares and horizontal lines correspond to the study-specific odds ratio (OR) and 95% confidence interval (CI).
Mentions: Regarding CYP1A2 rs762551 polymorphism, the eligible studies involved in 8218 cases and 11165 controls. For each study, we investigated the association based on the assumption of different inheritance models of CYP1A2 rs762551 A>C polymorphism. In all inheritance models of rs762551 polymorphism, due to the between-study heterogeneity in the individual studies (all P for Q test < 0.01 and I2>25%), the random-effect model was used to analyze the data[42]. We identified that rs762551 polymorphism had a weak correlation with the risk of cancer (CC versus AA, OR = 1.30, 95% CI = 1.02-1.64; dominant model, OR = 1.19, 95% CI = 1.04-1.36), but not in recessive model (OR = 1.19, 95% CI = 0.99-1.44) (Figure2 and Table2).

Bottom Line: The leave-one-out sensitivity analysis was conducted to determine whether our assumptions or decisions have a major effect on the results of the review.In subgroup analysis based on ethnicity, the rs762551CC genotype was associated with increased cancer risk (OR = 1.29, 95% CI = 1.27-1.63 in co-dominate model and OR = 1.17, 95% CI = 1.02-1.34 in dominant model in Caucasians, but not in Asians and the mixed population.These results suggested that CYP1A2 rs762551 polymorphism is likely to be associated with susceptibility to cancer in Caucasians.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Epidemiology, College of Public Health, Hebei United University, Tangshan 063000, China.

ABSTRACT

Background: Genetic polymorphism (rs762551A>C) in gene encoding cytochrome P450 1A2 (CYP1A2) has been shown to influence the inducibility of CYP1A2 expression and thus might be associated with risk of several types of human cancer. However, the results of previous studies on the associations of this polymorphism with risk of cancer are not all consistent. To clarify the potential contribution of CYP1A2 rs762551 to cancer risk, we performed a meta-analysis of the published case-control studies.

Methods: We used PubMed, Embase, OVID, ScienceDirect, and Chinese National Knowledge Infrastructure databases to identify the related publications for this meta-analysis. The pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using random effect model to evaluate the association of rs762551 with cancer risk. A χ(2)-based Q-test was used to examine the heterogeneity assumption and the funnel plot and Egger's test were used to examine the potential publication bias. The leave-one-out sensitivity analysis was conducted to determine whether our assumptions or decisions have a major effect on the results of the review.

Results: Our analysis of 19 eligible case-control studies showed a significant association between rs762551C variant with risk of cancer in the genetic model of CC versus AA (OR = 1.30, 95% CI = 1.02-1.64) and the dominant model (OR = 1.19, 95% CI = 1.04-1.36). In subgroup analysis based on ethnicity, the rs762551CC genotype was associated with increased cancer risk (OR = 1.29, 95% CI = 1.27-1.63 in co-dominate model and OR = 1.17, 95% CI = 1.02-1.34 in dominant model in Caucasians, but not in Asians and the mixed population.

Conclusion: These results suggested that CYP1A2 rs762551 polymorphism is likely to be associated with susceptibility to cancer in Caucasians.

Show MeSH
Related in: MedlinePlus