Limits...
APOE status modulates the changes in network connectivity induced by brain stimulation in non-demented elders.

Peña-Gomez C, Solé-Padullés C, Clemente IC, Junqué C, Bargalló N, Bosch B, Molinuevo JL, Valls-Solé J, Pascual-Leone A, Bartrés-Faz D - PLoS ONE (2012)

Bottom Line: Baseline task performance was associated with activation of a network of brain regions in prefrontal, parietal, medial temporal and visual associative areas.However, after rTMS APOE ε4-carriers showed significant changes in brain network activation, expressing strikingly similar spatial configuration as the one observed in the non-carrier group prior to stimulation.Similarly, activity in areas of the default-mode network (DMN) was found in a single component among the ε4-non bearers, whereas among carriers it appeared disaggregated in three distinct spatiotemporal components that changed to an integrated single component after rTMS.Our findings demonstrate that genetic background play a fundamental role in the brain responses to focal insults, conditioning expression of distinct brain networks to sustain similar cognitive performance.

View Article: PubMed Central - PubMed

Affiliation: Department de Psiquiatria i Psicobiologia Clinica, Universitat de Barcelona, Barcelona, Catalonia, Spain.

ABSTRACT
Behavioral consequences of a brain insult represent an interaction between the injury and the capacity of the rest of the brain to adapt to it. We provide experimental support for the notion that genetic factors play a critical role in such adaptation. We induced a controlled brain disruption using repetitive transcranial magnetic stimulation (rTMS) and show that APOE status determines its impact on distributed brain networks as assessed by functional MRI (fMRI).Twenty non-demented elders exhibiting mild memory dysfunction underwent two fMRI studies during face-name encoding tasks (before and after rTMS). Baseline task performance was associated with activation of a network of brain regions in prefrontal, parietal, medial temporal and visual associative areas. APOE ε4 bearers exhibited this pattern in two separate independent components, whereas ε4-non carriers presented a single partially overlapping network. Following rTMS all subjects showed slight ameliorations in memory performance, regardless of APOE status. However, after rTMS APOE ε4-carriers showed significant changes in brain network activation, expressing strikingly similar spatial configuration as the one observed in the non-carrier group prior to stimulation. Similarly, activity in areas of the default-mode network (DMN) was found in a single component among the ε4-non bearers, whereas among carriers it appeared disaggregated in three distinct spatiotemporal components that changed to an integrated single component after rTMS.Our findings demonstrate that genetic background play a fundamental role in the brain responses to focal insults, conditioning expression of distinct brain networks to sustain similar cognitive performance.

Show MeSH

Related in: MedlinePlus

Independent components (networks) that were significantly correlated with the deactivation period (DTBRP = deactivation-task brain related pattern).Networks are separated for each condition (pre-post TMS) and group (ε4 carriers-noncarriers). DTRP = Dectivation Task Related Patterns. Coordinates are given in MNI space. Intensity values are thresholded at z = 2.3. Brain areas of each network are fully described in table 4.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3526481&req=5

pone-0051833-g002: Independent components (networks) that were significantly correlated with the deactivation period (DTBRP = deactivation-task brain related pattern).Networks are separated for each condition (pre-post TMS) and group (ε4 carriers-noncarriers). DTRP = Dectivation Task Related Patterns. Coordinates are given in MNI space. Intensity values are thresholded at z = 2.3. Brain areas of each network are fully described in table 4.

Mentions: Figure 2 and table 3 depict different sets of independent components that were significantly correlated with the blocks of encoding of new face-name pairs, as well as with subsequent memory performance in each genetic subgroup.


APOE status modulates the changes in network connectivity induced by brain stimulation in non-demented elders.

Peña-Gomez C, Solé-Padullés C, Clemente IC, Junqué C, Bargalló N, Bosch B, Molinuevo JL, Valls-Solé J, Pascual-Leone A, Bartrés-Faz D - PLoS ONE (2012)

Independent components (networks) that were significantly correlated with the deactivation period (DTBRP = deactivation-task brain related pattern).Networks are separated for each condition (pre-post TMS) and group (ε4 carriers-noncarriers). DTRP = Dectivation Task Related Patterns. Coordinates are given in MNI space. Intensity values are thresholded at z = 2.3. Brain areas of each network are fully described in table 4.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3526481&req=5

pone-0051833-g002: Independent components (networks) that were significantly correlated with the deactivation period (DTBRP = deactivation-task brain related pattern).Networks are separated for each condition (pre-post TMS) and group (ε4 carriers-noncarriers). DTRP = Dectivation Task Related Patterns. Coordinates are given in MNI space. Intensity values are thresholded at z = 2.3. Brain areas of each network are fully described in table 4.
Mentions: Figure 2 and table 3 depict different sets of independent components that were significantly correlated with the blocks of encoding of new face-name pairs, as well as with subsequent memory performance in each genetic subgroup.

Bottom Line: Baseline task performance was associated with activation of a network of brain regions in prefrontal, parietal, medial temporal and visual associative areas.However, after rTMS APOE ε4-carriers showed significant changes in brain network activation, expressing strikingly similar spatial configuration as the one observed in the non-carrier group prior to stimulation.Similarly, activity in areas of the default-mode network (DMN) was found in a single component among the ε4-non bearers, whereas among carriers it appeared disaggregated in three distinct spatiotemporal components that changed to an integrated single component after rTMS.Our findings demonstrate that genetic background play a fundamental role in the brain responses to focal insults, conditioning expression of distinct brain networks to sustain similar cognitive performance.

View Article: PubMed Central - PubMed

Affiliation: Department de Psiquiatria i Psicobiologia Clinica, Universitat de Barcelona, Barcelona, Catalonia, Spain.

ABSTRACT
Behavioral consequences of a brain insult represent an interaction between the injury and the capacity of the rest of the brain to adapt to it. We provide experimental support for the notion that genetic factors play a critical role in such adaptation. We induced a controlled brain disruption using repetitive transcranial magnetic stimulation (rTMS) and show that APOE status determines its impact on distributed brain networks as assessed by functional MRI (fMRI).Twenty non-demented elders exhibiting mild memory dysfunction underwent two fMRI studies during face-name encoding tasks (before and after rTMS). Baseline task performance was associated with activation of a network of brain regions in prefrontal, parietal, medial temporal and visual associative areas. APOE ε4 bearers exhibited this pattern in two separate independent components, whereas ε4-non carriers presented a single partially overlapping network. Following rTMS all subjects showed slight ameliorations in memory performance, regardless of APOE status. However, after rTMS APOE ε4-carriers showed significant changes in brain network activation, expressing strikingly similar spatial configuration as the one observed in the non-carrier group prior to stimulation. Similarly, activity in areas of the default-mode network (DMN) was found in a single component among the ε4-non bearers, whereas among carriers it appeared disaggregated in three distinct spatiotemporal components that changed to an integrated single component after rTMS.Our findings demonstrate that genetic background play a fundamental role in the brain responses to focal insults, conditioning expression of distinct brain networks to sustain similar cognitive performance.

Show MeSH
Related in: MedlinePlus