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Primary pulmonary mucoepidermoid carcinoma: an analysis of 21 cases.

Xi JJ, Jiang W, Lu SH, Zhang CY, Fan H, Wang Q - World J Surg Oncol (2012)

Bottom Line: The prognosis was found to be poor in the presence of lymph nodes.Log-rank test results indicated that age, grade, lymph node metastasis, and tumor-node-metastasis stage were prognostic factors.Written informed consent was obtained from all participants prior to treatment.

View Article: PubMed Central - HTML - PubMed

Affiliation: Division of Thoracic Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.

ABSTRACT

Background: The optimal treatment for pulmonary mucoepidermoid carcinoma (MEC), a rare type of tumor, has not been established yet. This study analyzed the survival of pulmonary MEC patients and attempted to find clues for optimal treatment.

Methods: A total of 21 patients with pulmonary MEC from November 2004 to January 2011 were included in the investigation. Immunohistochemistry, epidermal growth factor receptor (EGFR) mutation, and survival were retrospectively studied.

Results: Among the 21 pulmonary MEC patients, 17 were diagnosed with low-grade malignancy and 4 with high-grade malignancy through pathological examination. The prognosis was found to be poor in the presence of lymph nodes. The expression rates of EGFR and HER2 were 28.6% and 0%, respectively, which correlated with neither grade nor prognosis. The mutation rate of EGFR was 0. Log-rank test results indicated that age, grade, lymph node metastasis, and tumor-node-metastasis stage were prognostic factors.

Conclusion: Age, grade, lymph node metastasis and tumor-node-metastasis stage correlate with the survival of pulmonary MEC patients.

Trial registration: This study was approved and registered by the Ethics Committee of Zhongshan Hospital. Written informed consent was obtained from all participants prior to treatment.

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Related in: MedlinePlus

Representative images of immunohistochemistry staining. (A) Positive EGFR expression, 100×; (B) positive EGFR expression, 400×; (C) false-positive HER2 expression because only cytoplasmic staining was observed, 100×; (D) false-positive HER2 expression because only cytoplasmic staining was observed, 400×.
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Figure 2: Representative images of immunohistochemistry staining. (A) Positive EGFR expression, 100×; (B) positive EGFR expression, 400×; (C) false-positive HER2 expression because only cytoplasmic staining was observed, 100×; (D) false-positive HER2 expression because only cytoplasmic staining was observed, 400×.

Mentions: Table2 describes the expression of EGFR, and the specimen was considered positive if the percentage/intensity was >10%+. The positive rates of EGFR and HER2 were 28.6% (6/21) and 0%, respectively (Figure2). The expression of EGFR was not associated with differentiation (P = 1) or lymph node metastasis (P = 0.28).


Primary pulmonary mucoepidermoid carcinoma: an analysis of 21 cases.

Xi JJ, Jiang W, Lu SH, Zhang CY, Fan H, Wang Q - World J Surg Oncol (2012)

Representative images of immunohistochemistry staining. (A) Positive EGFR expression, 100×; (B) positive EGFR expression, 400×; (C) false-positive HER2 expression because only cytoplasmic staining was observed, 100×; (D) false-positive HER2 expression because only cytoplasmic staining was observed, 400×.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3526401&req=5

Figure 2: Representative images of immunohistochemistry staining. (A) Positive EGFR expression, 100×; (B) positive EGFR expression, 400×; (C) false-positive HER2 expression because only cytoplasmic staining was observed, 100×; (D) false-positive HER2 expression because only cytoplasmic staining was observed, 400×.
Mentions: Table2 describes the expression of EGFR, and the specimen was considered positive if the percentage/intensity was >10%+. The positive rates of EGFR and HER2 were 28.6% (6/21) and 0%, respectively (Figure2). The expression of EGFR was not associated with differentiation (P = 1) or lymph node metastasis (P = 0.28).

Bottom Line: The prognosis was found to be poor in the presence of lymph nodes.Log-rank test results indicated that age, grade, lymph node metastasis, and tumor-node-metastasis stage were prognostic factors.Written informed consent was obtained from all participants prior to treatment.

View Article: PubMed Central - HTML - PubMed

Affiliation: Division of Thoracic Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.

ABSTRACT

Background: The optimal treatment for pulmonary mucoepidermoid carcinoma (MEC), a rare type of tumor, has not been established yet. This study analyzed the survival of pulmonary MEC patients and attempted to find clues for optimal treatment.

Methods: A total of 21 patients with pulmonary MEC from November 2004 to January 2011 were included in the investigation. Immunohistochemistry, epidermal growth factor receptor (EGFR) mutation, and survival were retrospectively studied.

Results: Among the 21 pulmonary MEC patients, 17 were diagnosed with low-grade malignancy and 4 with high-grade malignancy through pathological examination. The prognosis was found to be poor in the presence of lymph nodes. The expression rates of EGFR and HER2 were 28.6% and 0%, respectively, which correlated with neither grade nor prognosis. The mutation rate of EGFR was 0. Log-rank test results indicated that age, grade, lymph node metastasis, and tumor-node-metastasis stage were prognostic factors.

Conclusion: Age, grade, lymph node metastasis and tumor-node-metastasis stage correlate with the survival of pulmonary MEC patients.

Trial registration: This study was approved and registered by the Ethics Committee of Zhongshan Hospital. Written informed consent was obtained from all participants prior to treatment.

Show MeSH
Related in: MedlinePlus