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Editorial: NAR Awards 2012

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Stoddard The crystal structure of PthXo1 bound to its DNA target was determined with the use of a novel high-throughput computational structure prediction method, that was subsequently validated by heavy-atom derivitization... The structure illustrates the structural basis for site recognition by TAL effectors, which are now used by many laboratories for targeted gene modification experiments... Jones, and Scott A... Strobel Carly investigated which modifications to the bacterial second messenger c-di-GMP render the dinucleotide resistant to enzymatic degradation by the proteins that degrade the second messenger in the cell, as well as the effects of those analogs determined to be nuclease resistant on bacterial biofilm formation... In this study, Joël showed that viral protein 1 of Nora virus counteracts the antiviral RNAi pathway by inhibiting the endonucleic cleavage activity of the host Argonaute-2 protein... Vincent’s study reveals that the siRNA pathway is a broad antiviral defense mechanism, controlling not only the infection by RNA viruses, but also by a DNA virus (IIV-6), whereas the inducible antiviral response appears to be virus specific, unlike the interferon mediated inducible response in vertebrates... Dengue Virus NS4B is a Suppressor of RNAi Pavan Kumar Kakumani, Sanket Singh Ponia, Vikas Sood, Mahendran Chinnappan, Akhil C Banerjea, Pawan Malhotra, Sunil Mukherjee, Raj Bhatnagar In this work, Pavan showed that Dengue NS4B protein may contribute to virus replication by defying the host RNAi response in mammalian cells... Montréal, Québec, Canada 5–9 August, 2012 Optimizing DNA Detection Using Amplification by Destabilization Katie Mitran, Abu Kausar, Yimeng Li, Julianne Gibbs-Davis Katie has developed a method for isothermal DNA self-replication that can be applied to the development of point-of-care diagnostic systems... Her poster reports on a strategy that enables sensitive detection, temperature tunability and simplified result read-out methods... Landry Using a loss of function genetic screen using RNA interference, Claire identified genes which, when silenced, are synthetically lethal with a low dose of PAPR inhibitor ABT-888 in human pancreatic cancer cells Bonn, Germany 4–7 October, 2012 N3BC–A Powerful Label for RNA, DNA and Proteins Alike Stefanie Kellner, Salifu Seidu-Larry, Jürgen Burhenne, Yuri Motorin and Mark Helm Stefanie reported on N3BC, a post-transcriptional, uridine selective agent for versatile photoaffinity labeling and click chemistry of RNA, which is, in addition, usable on DNA and proteins... Amido-Bridged Nucleic Acid: Synthesis, Duplex Stability, Nuclease Resistance, and In Vitro Antisense Potency Aiko Yahara, Ajaya Ram Shrestha, Tsuyoshi Yamamoto, Yoshiyuki Hari, Takashi Osawa, Masaki Yamaguchi, Masaru Nishida, Tetsuya Kodama, Satoshi Obika Aiko described various urea, hydroxamate and amide-bridged analogues of 2′-4′-BNA/LNA... The potency of the amide analogue (AmNA) was greater than the corresponding 2′-4′-BNA/LNA in antisense targeting of human ApoB mRNA... Keith Fox, Senior Editor, Nucleic Acids Research Barry Stoddard, Senior Editor, Nucleic Acids Research

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Poster Prize winners at the Oligonucleotide Therapeutics Society meeting, Boston, 28–31 October 2012.
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gks1317-F1: Poster Prize winners at the Oligonucleotide Therapeutics Society meeting, Boston, 28–31 October 2012.


Editorial: NAR Awards 2012
Poster Prize winners at the Oligonucleotide Therapeutics Society meeting, Boston, 28–31 October 2012.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3526274&req=5

gks1317-F1: Poster Prize winners at the Oligonucleotide Therapeutics Society meeting, Boston, 28–31 October 2012.

View Article: PubMed Central

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Stoddard The crystal structure of PthXo1 bound to its DNA target was determined with the use of a novel high-throughput computational structure prediction method, that was subsequently validated by heavy-atom derivitization... The structure illustrates the structural basis for site recognition by TAL effectors, which are now used by many laboratories for targeted gene modification experiments... Jones, and Scott A... Strobel Carly investigated which modifications to the bacterial second messenger c-di-GMP render the dinucleotide resistant to enzymatic degradation by the proteins that degrade the second messenger in the cell, as well as the effects of those analogs determined to be nuclease resistant on bacterial biofilm formation... In this study, Joël showed that viral protein 1 of Nora virus counteracts the antiviral RNAi pathway by inhibiting the endonucleic cleavage activity of the host Argonaute-2 protein... Vincent’s study reveals that the siRNA pathway is a broad antiviral defense mechanism, controlling not only the infection by RNA viruses, but also by a DNA virus (IIV-6), whereas the inducible antiviral response appears to be virus specific, unlike the interferon mediated inducible response in vertebrates... Dengue Virus NS4B is a Suppressor of RNAi Pavan Kumar Kakumani, Sanket Singh Ponia, Vikas Sood, Mahendran Chinnappan, Akhil C Banerjea, Pawan Malhotra, Sunil Mukherjee, Raj Bhatnagar In this work, Pavan showed that Dengue NS4B protein may contribute to virus replication by defying the host RNAi response in mammalian cells... Montréal, Québec, Canada 5–9 August, 2012 Optimizing DNA Detection Using Amplification by Destabilization Katie Mitran, Abu Kausar, Yimeng Li, Julianne Gibbs-Davis Katie has developed a method for isothermal DNA self-replication that can be applied to the development of point-of-care diagnostic systems... Her poster reports on a strategy that enables sensitive detection, temperature tunability and simplified result read-out methods... Landry Using a loss of function genetic screen using RNA interference, Claire identified genes which, when silenced, are synthetically lethal with a low dose of PAPR inhibitor ABT-888 in human pancreatic cancer cells Bonn, Germany 4–7 October, 2012 N3BC–A Powerful Label for RNA, DNA and Proteins Alike Stefanie Kellner, Salifu Seidu-Larry, Jürgen Burhenne, Yuri Motorin and Mark Helm Stefanie reported on N3BC, a post-transcriptional, uridine selective agent for versatile photoaffinity labeling and click chemistry of RNA, which is, in addition, usable on DNA and proteins... Amido-Bridged Nucleic Acid: Synthesis, Duplex Stability, Nuclease Resistance, and In Vitro Antisense Potency Aiko Yahara, Ajaya Ram Shrestha, Tsuyoshi Yamamoto, Yoshiyuki Hari, Takashi Osawa, Masaki Yamaguchi, Masaru Nishida, Tetsuya Kodama, Satoshi Obika Aiko described various urea, hydroxamate and amide-bridged analogues of 2′-4′-BNA/LNA... The potency of the amide analogue (AmNA) was greater than the corresponding 2′-4′-BNA/LNA in antisense targeting of human ApoB mRNA... Keith Fox, Senior Editor, Nucleic Acids Research Barry Stoddard, Senior Editor, Nucleic Acids Research

No MeSH data available.