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Effects of lipid regulation using raw and processed radix polygoni multiflori in rats fed a high-fat diet.

Li N, Chen Z, Mao X, Yu J, Zhao R - Evid Based Complement Alternat Med (2012)

Bottom Line: Both Radix Polygoni Multiflori (RPM) and Radix Polygoni Multiflori Praeparata (RPMP) revealed TC-lowing effects, and middling doses of RPMP displayed the most significant TC-lowing effects, as indicated by blood samples.Nevertheless, RPM showed dose-dependent TC- and TG-lowing effects in the liver tissue samples.RPMP, however, displayed better effects in regulating lipids in circulating blood for the treatment of hyperlipidemia.

View Article: PubMed Central - PubMed

Affiliation: Yunnan University of Traditional Chinese Medicine, Kunming, Yunnan 650500, China.

ABSTRACT
Raw and processed Radix Polygoni Multiflori have been used in the prevention and treatment of nonalcoholic fatty liver disease (NAFLD), hyperlipidemia, and related diseases in Asian counties for centuries. The lipid regulation ability of raw and processed Poligoni Multiflori Radix were compared in high-fat diet fed rats in this research. Total cholesterol (TC) and low density lipoprotein-cholesterol (LDL-C) in blood and liver tissue were all significantly higher in model rats. However, triglyceride (TG) contents increased only in liver tissue, not in the blood samples. The rats fed the high-fat diets were considered the model of type IIa hyperlipidemia and early-stage nonalcoholic fatty liver disease. Both Radix Polygoni Multiflori (RPM) and Radix Polygoni Multiflori Praeparata (RPMP) revealed TC-lowing effects, and middling doses of RPMP displayed the most significant TC-lowing effects, as indicated by blood samples. Neither RPM nor RPMP was found to reduce LDL-C in rats' blood. Nevertheless, RPM showed dose-dependent TC- and TG-lowing effects in the liver tissue samples. In conclusion, RPM showed more pronounced effects on lipid regulation in liver samples in the treatment of early-stage NAFLD. RPMP, however, displayed better effects in regulating lipids in circulating blood for the treatment of hyperlipidemia.

No MeSH data available.


Related in: MedlinePlus

Body weight (a) and indexes of liver (b), kidney (c), and spleen (d) of rats in different groups. Note: The body weight was measured in every five days, however, only the data in 0th, 18th, 30th, and 42nd day were listed in this figure. The * indicates a significant difference compared with control group, *P < 0.05 and ***P < 0.001. The # indicates a significant difference compared with model group, #P < 0.05.
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fig2: Body weight (a) and indexes of liver (b), kidney (c), and spleen (d) of rats in different groups. Note: The body weight was measured in every five days, however, only the data in 0th, 18th, 30th, and 42nd day were listed in this figure. The * indicates a significant difference compared with control group, *P < 0.05 and ***P < 0.001. The # indicates a significant difference compared with model group, #P < 0.05.

Mentions: One hundred and twenty Sprague-Dawley rats of either sex were randomly divided into 10 groups of twelve in each (Table 1). The rats fed on normal diets showed about 43% weight gain in 42 days of experiment duration (Figure 2(a)). However, the body weights of rats fed high-fat diets were significantly lighter than those of rats fed normal diets groups beginning on day 18 day and persisted until the end of the experiment across all treatment groups (Figure 2(a)). We attributed the weight loss to the rats' displeasure with the taste of the high-fat diets.


Effects of lipid regulation using raw and processed radix polygoni multiflori in rats fed a high-fat diet.

Li N, Chen Z, Mao X, Yu J, Zhao R - Evid Based Complement Alternat Med (2012)

Body weight (a) and indexes of liver (b), kidney (c), and spleen (d) of rats in different groups. Note: The body weight was measured in every five days, however, only the data in 0th, 18th, 30th, and 42nd day were listed in this figure. The * indicates a significant difference compared with control group, *P < 0.05 and ***P < 0.001. The # indicates a significant difference compared with model group, #P < 0.05.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3526257&req=5

fig2: Body weight (a) and indexes of liver (b), kidney (c), and spleen (d) of rats in different groups. Note: The body weight was measured in every five days, however, only the data in 0th, 18th, 30th, and 42nd day were listed in this figure. The * indicates a significant difference compared with control group, *P < 0.05 and ***P < 0.001. The # indicates a significant difference compared with model group, #P < 0.05.
Mentions: One hundred and twenty Sprague-Dawley rats of either sex were randomly divided into 10 groups of twelve in each (Table 1). The rats fed on normal diets showed about 43% weight gain in 42 days of experiment duration (Figure 2(a)). However, the body weights of rats fed high-fat diets were significantly lighter than those of rats fed normal diets groups beginning on day 18 day and persisted until the end of the experiment across all treatment groups (Figure 2(a)). We attributed the weight loss to the rats' displeasure with the taste of the high-fat diets.

Bottom Line: Both Radix Polygoni Multiflori (RPM) and Radix Polygoni Multiflori Praeparata (RPMP) revealed TC-lowing effects, and middling doses of RPMP displayed the most significant TC-lowing effects, as indicated by blood samples.Nevertheless, RPM showed dose-dependent TC- and TG-lowing effects in the liver tissue samples.RPMP, however, displayed better effects in regulating lipids in circulating blood for the treatment of hyperlipidemia.

View Article: PubMed Central - PubMed

Affiliation: Yunnan University of Traditional Chinese Medicine, Kunming, Yunnan 650500, China.

ABSTRACT
Raw and processed Radix Polygoni Multiflori have been used in the prevention and treatment of nonalcoholic fatty liver disease (NAFLD), hyperlipidemia, and related diseases in Asian counties for centuries. The lipid regulation ability of raw and processed Poligoni Multiflori Radix were compared in high-fat diet fed rats in this research. Total cholesterol (TC) and low density lipoprotein-cholesterol (LDL-C) in blood and liver tissue were all significantly higher in model rats. However, triglyceride (TG) contents increased only in liver tissue, not in the blood samples. The rats fed the high-fat diets were considered the model of type IIa hyperlipidemia and early-stage nonalcoholic fatty liver disease. Both Radix Polygoni Multiflori (RPM) and Radix Polygoni Multiflori Praeparata (RPMP) revealed TC-lowing effects, and middling doses of RPMP displayed the most significant TC-lowing effects, as indicated by blood samples. Neither RPM nor RPMP was found to reduce LDL-C in rats' blood. Nevertheless, RPM showed dose-dependent TC- and TG-lowing effects in the liver tissue samples. In conclusion, RPM showed more pronounced effects on lipid regulation in liver samples in the treatment of early-stage NAFLD. RPMP, however, displayed better effects in regulating lipids in circulating blood for the treatment of hyperlipidemia.

No MeSH data available.


Related in: MedlinePlus