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β-cell mass and turnover in humans: effects of obesity and aging.

Saisho Y, Butler AE, Manesso E, Elashoff D, Rizza RA, Butler PC - Diabetes Care (2012)

Bottom Line: We examined human autopsy pancreas from 167 nondiabetic individuals 20-102 years of age.The effect of obesity on β-cell mass was examined in 53 lean and 61 obese subjects, and the effect of aging was examined in 106 lean subjects. β-Cell mass is increased by ~50% with obesity (from 0.8 to 1.2 g).With advanced aging, the exocrine pancreas undergoes atrophy but β-cell mass is remarkably preserved.

View Article: PubMed Central - PubMed

Affiliation: Larry L. Hillblom Islet Research Center, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, USA.

ABSTRACT

Objective: We sought to establish β-cell mass, β-cell apoptosis, and β-cell replication in humans in response to obesity and advanced age.

Research design and methods: We examined human autopsy pancreas from 167 nondiabetic individuals 20-102 years of age. The effect of obesity on β-cell mass was examined in 53 lean and 61 obese subjects, and the effect of aging was examined in 106 lean subjects.

Results: β-Cell mass is increased by ~50% with obesity (from 0.8 to 1.2 g). With advanced aging, the exocrine pancreas undergoes atrophy but β-cell mass is remarkably preserved. There is minimal β-cell replication or apoptosis in lean humans throughout life with no detectable changes with obesity or advanced age.

Conclusions: β-Cell mass in human obesity increases by ~50% by an increase in β-cell number, the source of which is unknown. β-Cell mass is well preserved in humans with advanced aging.

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Related in: MedlinePlus

Fractional β-cell area (A), estimated pancreas parenchymal volume (B), and computed β-cell mass (C) in lean and obese nondiabetic subjects. The pancreatic fractional β-cell area was ∼30% greater in the obese vs. the lean group (A). Estimated pancreas parenchymal volume (see research design and methods) was ∼15% greater in the obese vs. the lean subjects (B). In consequence, the computed mean β-cell mass was ∼50% higher in obese subjects (0.8 g in lean and 1.2 g in obese) (C). However, there was no increase in mean individual β-cell size in obese subjects (D).
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Figure 2: Fractional β-cell area (A), estimated pancreas parenchymal volume (B), and computed β-cell mass (C) in lean and obese nondiabetic subjects. The pancreatic fractional β-cell area was ∼30% greater in the obese vs. the lean group (A). Estimated pancreas parenchymal volume (see research design and methods) was ∼15% greater in the obese vs. the lean subjects (B). In consequence, the computed mean β-cell mass was ∼50% higher in obese subjects (0.8 g in lean and 1.2 g in obese) (C). However, there was no increase in mean individual β-cell size in obese subjects (D).

Mentions: The fractional β-cell/pancreas parenchymal area is ∼30% higher in the obese compared with the lean group (2.2 ± 0.1 vs. 1.6 ± 0.1%, P < 0.01) (Figs. 1 and 2A). β-Cell mass is ∼50% higher in the obese compared with the lean group (1.2 ± 0.1 vs. 0.8 ± 0.04 g, P < 0.0001) (Fig. 2). Both the fractional β-cell area (r = 0.3, P = 0.001) and the calculated β-cell mass (r = 0.5, P < 0.0001) (Fig. 3) are increased as a function of BMI, although there is considerable variance in β-cell mass not explained by BMI. There is no correlation between β-cell mass and FPG, although the range of the FPG is, by design (all nondiabetic), narrow.


β-cell mass and turnover in humans: effects of obesity and aging.

Saisho Y, Butler AE, Manesso E, Elashoff D, Rizza RA, Butler PC - Diabetes Care (2012)

Fractional β-cell area (A), estimated pancreas parenchymal volume (B), and computed β-cell mass (C) in lean and obese nondiabetic subjects. The pancreatic fractional β-cell area was ∼30% greater in the obese vs. the lean group (A). Estimated pancreas parenchymal volume (see research design and methods) was ∼15% greater in the obese vs. the lean subjects (B). In consequence, the computed mean β-cell mass was ∼50% higher in obese subjects (0.8 g in lean and 1.2 g in obese) (C). However, there was no increase in mean individual β-cell size in obese subjects (D).
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3526241&req=5

Figure 2: Fractional β-cell area (A), estimated pancreas parenchymal volume (B), and computed β-cell mass (C) in lean and obese nondiabetic subjects. The pancreatic fractional β-cell area was ∼30% greater in the obese vs. the lean group (A). Estimated pancreas parenchymal volume (see research design and methods) was ∼15% greater in the obese vs. the lean subjects (B). In consequence, the computed mean β-cell mass was ∼50% higher in obese subjects (0.8 g in lean and 1.2 g in obese) (C). However, there was no increase in mean individual β-cell size in obese subjects (D).
Mentions: The fractional β-cell/pancreas parenchymal area is ∼30% higher in the obese compared with the lean group (2.2 ± 0.1 vs. 1.6 ± 0.1%, P < 0.01) (Figs. 1 and 2A). β-Cell mass is ∼50% higher in the obese compared with the lean group (1.2 ± 0.1 vs. 0.8 ± 0.04 g, P < 0.0001) (Fig. 2). Both the fractional β-cell area (r = 0.3, P = 0.001) and the calculated β-cell mass (r = 0.5, P < 0.0001) (Fig. 3) are increased as a function of BMI, although there is considerable variance in β-cell mass not explained by BMI. There is no correlation between β-cell mass and FPG, although the range of the FPG is, by design (all nondiabetic), narrow.

Bottom Line: We examined human autopsy pancreas from 167 nondiabetic individuals 20-102 years of age.The effect of obesity on β-cell mass was examined in 53 lean and 61 obese subjects, and the effect of aging was examined in 106 lean subjects. β-Cell mass is increased by ~50% with obesity (from 0.8 to 1.2 g).With advanced aging, the exocrine pancreas undergoes atrophy but β-cell mass is remarkably preserved.

View Article: PubMed Central - PubMed

Affiliation: Larry L. Hillblom Islet Research Center, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, USA.

ABSTRACT

Objective: We sought to establish β-cell mass, β-cell apoptosis, and β-cell replication in humans in response to obesity and advanced age.

Research design and methods: We examined human autopsy pancreas from 167 nondiabetic individuals 20-102 years of age. The effect of obesity on β-cell mass was examined in 53 lean and 61 obese subjects, and the effect of aging was examined in 106 lean subjects.

Results: β-Cell mass is increased by ~50% with obesity (from 0.8 to 1.2 g). With advanced aging, the exocrine pancreas undergoes atrophy but β-cell mass is remarkably preserved. There is minimal β-cell replication or apoptosis in lean humans throughout life with no detectable changes with obesity or advanced age.

Conclusions: β-Cell mass in human obesity increases by ~50% by an increase in β-cell number, the source of which is unknown. β-Cell mass is well preserved in humans with advanced aging.

Show MeSH
Related in: MedlinePlus