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Measuring affective reactivity in individuals with autism spectrum personality traits using the visual mismatch negativity event-related brain potential.

Gayle LC, Gal DE, Kieffaber PD - Front Hum Neurosci (2012)

Bottom Line: Consistent with prior research, it was anticipated that the amplitude of the vMMN would be increased for emotionally salient stimuli.Higher AQ scores were associated with smaller amplitudes of the vMMN in response to happy, but not sad emotional deviants.This research suggests that the vMMN elicited by deviant emotional expressions may be a useful indicator of affective reactivity and may thus be related to social competency in Autism Spectrum Disorder (ASD).

View Article: PubMed Central - PubMed

Affiliation: Department of Psychology, The College of William and Mary Williamsburg, VA, USA.

ABSTRACT
The primary aim of this research was to determine how modulation of the visual mismatch negativity (vMMN) by emotionally laden faces is related to autism spectrum personality traits. Emotionally neutral faces served as the standard stimuli and happy and sad expressions served as vMMN-eliciting deviants. Consistent with prior research, it was anticipated that the amplitude of the vMMN would be increased for emotionally salient stimuli. Extending this finding, it was expected that this emotion-based amplitude sensitivity of the vMMN would be decreased in individuals with higher levels of autism spectrum personality traits as measured by the Adult Autism Spectrum Quotient (AQ). Higher AQ scores were associated with smaller amplitudes of the vMMN in response to happy, but not sad emotional deviants. The fact that higher AQ scores were associated with less sensitivity only to happy emotional expressions is interpreted to be consistent with the negative experience of social interactions reported by individuals who are high on the autism spectrum. This research suggests that the vMMN elicited by deviant emotional expressions may be a useful indicator of affective reactivity and may thus be related to social competency in Autism Spectrum Disorder (ASD).

No MeSH data available.


Related in: MedlinePlus

Left: Butterfly plot of grand average vMMN waveforms (deviant minus standard) at all electrode sites separately for each of the deviant stimuli. Right: Scalp topographies of mean vMMN amplitude (deviant minus standard) over the 150–425 ms epoch for each condition.
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Figure 2: Left: Butterfly plot of grand average vMMN waveforms (deviant minus standard) at all electrode sites separately for each of the deviant stimuli. Right: Scalp topographies of mean vMMN amplitude (deviant minus standard) over the 150–425 ms epoch for each condition.

Mentions: vMMN was identified and measured for each condition in the difference waveform generated by subtracting the ERP in response to the Standard image from the ERP in response to the happy, sad, and control deviant images. Combined with prior research (Zhao and Li, 2006), an evaluation of the grand average difference waveforms in Figure 2 informed the decision to measure vMMN as the mean amplitude between 150 and 425 ms at parieto-occipital electrodes (P03, P04, P07, P08). A 3 (Emotion: happy, sad, and control) × 2 [Hemisphere: right (P04, PO8), left (P03, P07)] × 2 [Region: medial (PO3, PO4), lateral (P07, PO8)] repeated measures ANOVA was used to assess amplitude variability across emotional expressions, hemispheres, and medial/lateral regions. Greenhouse–Geisser correction for violations of sphericity was used where appropriate. Guided by the results of the ANOVA, a Pearson correlation coefficient was used to determine the relationship between vMMN amplitude and scores on the AQ.


Measuring affective reactivity in individuals with autism spectrum personality traits using the visual mismatch negativity event-related brain potential.

Gayle LC, Gal DE, Kieffaber PD - Front Hum Neurosci (2012)

Left: Butterfly plot of grand average vMMN waveforms (deviant minus standard) at all electrode sites separately for each of the deviant stimuli. Right: Scalp topographies of mean vMMN amplitude (deviant minus standard) over the 150–425 ms epoch for each condition.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3526074&req=5

Figure 2: Left: Butterfly plot of grand average vMMN waveforms (deviant minus standard) at all electrode sites separately for each of the deviant stimuli. Right: Scalp topographies of mean vMMN amplitude (deviant minus standard) over the 150–425 ms epoch for each condition.
Mentions: vMMN was identified and measured for each condition in the difference waveform generated by subtracting the ERP in response to the Standard image from the ERP in response to the happy, sad, and control deviant images. Combined with prior research (Zhao and Li, 2006), an evaluation of the grand average difference waveforms in Figure 2 informed the decision to measure vMMN as the mean amplitude between 150 and 425 ms at parieto-occipital electrodes (P03, P04, P07, P08). A 3 (Emotion: happy, sad, and control) × 2 [Hemisphere: right (P04, PO8), left (P03, P07)] × 2 [Region: medial (PO3, PO4), lateral (P07, PO8)] repeated measures ANOVA was used to assess amplitude variability across emotional expressions, hemispheres, and medial/lateral regions. Greenhouse–Geisser correction for violations of sphericity was used where appropriate. Guided by the results of the ANOVA, a Pearson correlation coefficient was used to determine the relationship between vMMN amplitude and scores on the AQ.

Bottom Line: Consistent with prior research, it was anticipated that the amplitude of the vMMN would be increased for emotionally salient stimuli.Higher AQ scores were associated with smaller amplitudes of the vMMN in response to happy, but not sad emotional deviants.This research suggests that the vMMN elicited by deviant emotional expressions may be a useful indicator of affective reactivity and may thus be related to social competency in Autism Spectrum Disorder (ASD).

View Article: PubMed Central - PubMed

Affiliation: Department of Psychology, The College of William and Mary Williamsburg, VA, USA.

ABSTRACT
The primary aim of this research was to determine how modulation of the visual mismatch negativity (vMMN) by emotionally laden faces is related to autism spectrum personality traits. Emotionally neutral faces served as the standard stimuli and happy and sad expressions served as vMMN-eliciting deviants. Consistent with prior research, it was anticipated that the amplitude of the vMMN would be increased for emotionally salient stimuli. Extending this finding, it was expected that this emotion-based amplitude sensitivity of the vMMN would be decreased in individuals with higher levels of autism spectrum personality traits as measured by the Adult Autism Spectrum Quotient (AQ). Higher AQ scores were associated with smaller amplitudes of the vMMN in response to happy, but not sad emotional deviants. The fact that higher AQ scores were associated with less sensitivity only to happy emotional expressions is interpreted to be consistent with the negative experience of social interactions reported by individuals who are high on the autism spectrum. This research suggests that the vMMN elicited by deviant emotional expressions may be a useful indicator of affective reactivity and may thus be related to social competency in Autism Spectrum Disorder (ASD).

No MeSH data available.


Related in: MedlinePlus