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Population-based study of high plasma C-reactive protein concentrations among the Inuit of Nunavik.

Labonté ME, Dewailly E, Chateau-Degat ML, Couture P, Lamarche B - Int J Circumpolar Health (2012)

Bottom Line: Multivariate logistic regression analysis indicated that every 1 mmHg increase in systolic BP was associated with a 3% increase in the odds of having hs-CRP concentrations ≥ 2 mg/L in the Inuit population (95% CI 1.01-1.04).The combination of older age (≥ 50 vs. <30 years) and elevated waist circumference (gender-specific cut-off values) in a multivariate logistic model was also associated with a 13.3-fold increase in the odds of having plasma hs-CRP concentrations ≥ 2 mg/L (95% CI 5.8-30.9).Sex, age, waist circumference and systolic BP are major factors that increase the risk of this inflammatory phenotype among Inuit from Nunavik, despite their different lifestyle background compared with Caucasians.

View Article: PubMed Central - PubMed

Affiliation: Institute of Nutraceuticals and Functional Foods, Laval University, Québec, QC, Canada.

ABSTRACT

Background: The shift away from traditional lifestyle in the Inuit population over the past few decades has been associated with an increased prevalence of coronary heart disease (CHD) risk factors such as obesity, high blood pressure (BP) and diabetes. However, the impact of this transition on the pro-inflammatory marker high-sensitivity C-reactive protein (hs-CRP) has not been documented.

Objectives: To examine the prevalence of elevated plasma hs-CRP concentrations in Inuit from Nunavik in the province of Quebec (Canada) and identify anthropometric, biochemical and lifestyle risk factors associated with elevated hs-CRP.

Design: A population-representative sample of 801 Inuit residents from 14 villages of Nunavik, aged between 18 and 74 years, was included in the analyses. Subjects participated in a clinical session and completed questionnaires on lifestyle. Multivariate logistic regression was used to determine risk factors for elevated hs-CRP.

Results: Elevated plasma hs-CRP concentrations (≥ 2 mg/L) were present in 32.7% (95% confidence interval (CI) 29.5-35.8) of the Inuit adult population and were more prevalent among women than among men (36.7% vs. 29.0%, p=0.007). Multivariate logistic regression analysis indicated that every 1 mmHg increase in systolic BP was associated with a 3% increase in the odds of having hs-CRP concentrations ≥ 2 mg/L in the Inuit population (95% CI 1.01-1.04). The combination of older age (≥ 50 vs. <30 years) and elevated waist circumference (gender-specific cut-off values) in a multivariate logistic model was also associated with a 13.3-fold increase in the odds of having plasma hs-CRP concentrations ≥ 2 mg/L (95% CI 5.8-30.9).

Conclusions: These data indicate that elevated hs-CRP is relatively prevalent among Inuit with values that are similar to those seen in Canadian Caucasian populations. Sex, age, waist circumference and systolic BP are major factors that increase the risk of this inflammatory phenotype among Inuit from Nunavik, despite their different lifestyle background compared with Caucasians.

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Related in: MedlinePlus

Flow of participants through the Nunavik Inuit Health Survey 2004.*58 subjects were excluded because they had hs-CRP concentrations ≥10 mg/L, which is indicative of an acute inflammatory response (17).
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Figure 0001: Flow of participants through the Nunavik Inuit Health Survey 2004.*58 subjects were excluded because they had hs-CRP concentrations ≥10 mg/L, which is indicative of an acute inflammatory response (17).

Mentions: Figure 1 illustrates the flow of participants throughout the study. Analyses were based on a sample of 801 Inuit adults among 919 recruited participants from whom a blood sample was taken. Overall, 20 participants were excluded from the analyses because they were non-Inuit, 26 women were excluded because they were pregnant and 14 subjects were excluded because of missing data on hs-CRP concentrations. Also, 58 subjects (7.0% of the population, 95% CI 5.3–8.7) were excluded because their hs-CRP concentrations were ≥10 mg/L, which is indicative of an active acute inflammatory response (17).


Population-based study of high plasma C-reactive protein concentrations among the Inuit of Nunavik.

Labonté ME, Dewailly E, Chateau-Degat ML, Couture P, Lamarche B - Int J Circumpolar Health (2012)

Flow of participants through the Nunavik Inuit Health Survey 2004.*58 subjects were excluded because they had hs-CRP concentrations ≥10 mg/L, which is indicative of an acute inflammatory response (17).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3475996&req=5

Figure 0001: Flow of participants through the Nunavik Inuit Health Survey 2004.*58 subjects were excluded because they had hs-CRP concentrations ≥10 mg/L, which is indicative of an acute inflammatory response (17).
Mentions: Figure 1 illustrates the flow of participants throughout the study. Analyses were based on a sample of 801 Inuit adults among 919 recruited participants from whom a blood sample was taken. Overall, 20 participants were excluded from the analyses because they were non-Inuit, 26 women were excluded because they were pregnant and 14 subjects were excluded because of missing data on hs-CRP concentrations. Also, 58 subjects (7.0% of the population, 95% CI 5.3–8.7) were excluded because their hs-CRP concentrations were ≥10 mg/L, which is indicative of an active acute inflammatory response (17).

Bottom Line: Multivariate logistic regression analysis indicated that every 1 mmHg increase in systolic BP was associated with a 3% increase in the odds of having hs-CRP concentrations ≥ 2 mg/L in the Inuit population (95% CI 1.01-1.04).The combination of older age (≥ 50 vs. <30 years) and elevated waist circumference (gender-specific cut-off values) in a multivariate logistic model was also associated with a 13.3-fold increase in the odds of having plasma hs-CRP concentrations ≥ 2 mg/L (95% CI 5.8-30.9).Sex, age, waist circumference and systolic BP are major factors that increase the risk of this inflammatory phenotype among Inuit from Nunavik, despite their different lifestyle background compared with Caucasians.

View Article: PubMed Central - PubMed

Affiliation: Institute of Nutraceuticals and Functional Foods, Laval University, Québec, QC, Canada.

ABSTRACT

Background: The shift away from traditional lifestyle in the Inuit population over the past few decades has been associated with an increased prevalence of coronary heart disease (CHD) risk factors such as obesity, high blood pressure (BP) and diabetes. However, the impact of this transition on the pro-inflammatory marker high-sensitivity C-reactive protein (hs-CRP) has not been documented.

Objectives: To examine the prevalence of elevated plasma hs-CRP concentrations in Inuit from Nunavik in the province of Quebec (Canada) and identify anthropometric, biochemical and lifestyle risk factors associated with elevated hs-CRP.

Design: A population-representative sample of 801 Inuit residents from 14 villages of Nunavik, aged between 18 and 74 years, was included in the analyses. Subjects participated in a clinical session and completed questionnaires on lifestyle. Multivariate logistic regression was used to determine risk factors for elevated hs-CRP.

Results: Elevated plasma hs-CRP concentrations (≥ 2 mg/L) were present in 32.7% (95% confidence interval (CI) 29.5-35.8) of the Inuit adult population and were more prevalent among women than among men (36.7% vs. 29.0%, p=0.007). Multivariate logistic regression analysis indicated that every 1 mmHg increase in systolic BP was associated with a 3% increase in the odds of having hs-CRP concentrations ≥ 2 mg/L in the Inuit population (95% CI 1.01-1.04). The combination of older age (≥ 50 vs. <30 years) and elevated waist circumference (gender-specific cut-off values) in a multivariate logistic model was also associated with a 13.3-fold increase in the odds of having plasma hs-CRP concentrations ≥ 2 mg/L (95% CI 5.8-30.9).

Conclusions: These data indicate that elevated hs-CRP is relatively prevalent among Inuit with values that are similar to those seen in Canadian Caucasian populations. Sex, age, waist circumference and systolic BP are major factors that increase the risk of this inflammatory phenotype among Inuit from Nunavik, despite their different lifestyle background compared with Caucasians.

Show MeSH
Related in: MedlinePlus