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Computer-aided diagnosis system for bone scintigrams from Japanese patients: importance of training database.

Horikoshi H, Kikuchi A, Onoguchi M, Sjöstrand K, Edenbrandt L - Ann Nucl Med (2012)

Bottom Line: The final diagnostic results made by clinicians were used as gold standard.The Japanese CAD software showed a higher specificity and accuracy compared to the European CAD software [81 vs. 57 % (p < 0.05) and 82 vs. 61 % (p < 0.05), respectively].These results could at least partly be caused by the physical differences between Japanese and European patients resulting in less influence of attenuation in Japanese patients and possible different judgement of count intensities of hot spots.

View Article: PubMed Central - PubMed

Affiliation: Department of Diagnostic Radiology, Gunma Prefectural Cancer Center, Takabayashi Nishimachi 617-1, Ota, Gunma, 373-0828, Japan.

ABSTRACT

Aim: Computer-aided diagnosis (CAD) software for bone scintigrams have recently been introduced as a clinical quality assurance tool. The purpose of this study was to compare the diagnostic accuracy of two CAD systems, one based on a European and one on a Japanese training database, in a group of bone scans from Japanese patients.

Method: The two CAD software are trained to interpret bone scans using training databases consisting of bone scans with the desired interpretation, metastatic disease or not. One software was trained using 795 bone scans from European patients and the other with 904 bone scans from Japanese patients. The two CAD softwares were evaluated using the same group of 257 Japanese patients, who underwent bone scintigraphy because of suspected metastases of malignant tumors in 2009. The final diagnostic results made by clinicians were used as gold standard.

Results: The Japanese CAD software showed a higher specificity and accuracy compared to the European CAD software [81 vs. 57 % (p < 0.05) and 82 vs. 61 % (p < 0.05), respectively]. The sensitivity was 90 % for the Japanese CAD software and 83 % for the European CAD software (n.s).

Conclusion: The CAD software trained with a Japanese database showed significantly higher performance than the corresponding CAD software trained with a European database for the analysis of bone scans from Japanese patients. These results could at least partly be caused by the physical differences between Japanese and European patients resulting in less influence of attenuation in Japanese patients and possible different judgement of count intensities of hot spots.

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A 55-year-old man with lung cancer. Increased radiotracer uptake can mainly be seen in cranial bone, mandible, cervical spine, sternum, and right femur on whole-body scan (a, d). CAD software with European database (b, e) classifies as this patient as having no metastases (ANN 0.29, grade 2). However, CAD software with Japanese database (c, f) correctly classifies as having metastases (ANN 0.87, grade 4). CT imaging shows osteolytic bone metastasis corresponding to increased radiotracer uptake of cranial bone and right femur (not shown)
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Fig1: A 55-year-old man with lung cancer. Increased radiotracer uptake can mainly be seen in cranial bone, mandible, cervical spine, sternum, and right femur on whole-body scan (a, d). CAD software with European database (b, e) classifies as this patient as having no metastases (ANN 0.29, grade 2). However, CAD software with Japanese database (c, f) correctly classifies as having metastases (ANN 0.87, grade 4). CT imaging shows osteolytic bone metastasis corresponding to increased radiotracer uptake of cranial bone and right femur (not shown)

Mentions: Aiming at bone whole-body scan images (anterior and posterior images), a result is displayed through roughly two analysis flows comprising image analysis and ANN analysis as shown in Fig. 1. The analysis software BONENAVI (FUJIFILM RI Pharma Co., Ltd.) used in this study performs from analysis after data input to output almost automatically, and is excellent in convenience or repeatability.Fig. 1


Computer-aided diagnosis system for bone scintigrams from Japanese patients: importance of training database.

Horikoshi H, Kikuchi A, Onoguchi M, Sjöstrand K, Edenbrandt L - Ann Nucl Med (2012)

A 55-year-old man with lung cancer. Increased radiotracer uptake can mainly be seen in cranial bone, mandible, cervical spine, sternum, and right femur on whole-body scan (a, d). CAD software with European database (b, e) classifies as this patient as having no metastases (ANN 0.29, grade 2). However, CAD software with Japanese database (c, f) correctly classifies as having metastases (ANN 0.87, grade 4). CT imaging shows osteolytic bone metastasis corresponding to increased radiotracer uptake of cranial bone and right femur (not shown)
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3475966&req=5

Fig1: A 55-year-old man with lung cancer. Increased radiotracer uptake can mainly be seen in cranial bone, mandible, cervical spine, sternum, and right femur on whole-body scan (a, d). CAD software with European database (b, e) classifies as this patient as having no metastases (ANN 0.29, grade 2). However, CAD software with Japanese database (c, f) correctly classifies as having metastases (ANN 0.87, grade 4). CT imaging shows osteolytic bone metastasis corresponding to increased radiotracer uptake of cranial bone and right femur (not shown)
Mentions: Aiming at bone whole-body scan images (anterior and posterior images), a result is displayed through roughly two analysis flows comprising image analysis and ANN analysis as shown in Fig. 1. The analysis software BONENAVI (FUJIFILM RI Pharma Co., Ltd.) used in this study performs from analysis after data input to output almost automatically, and is excellent in convenience or repeatability.Fig. 1

Bottom Line: The final diagnostic results made by clinicians were used as gold standard.The Japanese CAD software showed a higher specificity and accuracy compared to the European CAD software [81 vs. 57 % (p < 0.05) and 82 vs. 61 % (p < 0.05), respectively].These results could at least partly be caused by the physical differences between Japanese and European patients resulting in less influence of attenuation in Japanese patients and possible different judgement of count intensities of hot spots.

View Article: PubMed Central - PubMed

Affiliation: Department of Diagnostic Radiology, Gunma Prefectural Cancer Center, Takabayashi Nishimachi 617-1, Ota, Gunma, 373-0828, Japan.

ABSTRACT

Aim: Computer-aided diagnosis (CAD) software for bone scintigrams have recently been introduced as a clinical quality assurance tool. The purpose of this study was to compare the diagnostic accuracy of two CAD systems, one based on a European and one on a Japanese training database, in a group of bone scans from Japanese patients.

Method: The two CAD software are trained to interpret bone scans using training databases consisting of bone scans with the desired interpretation, metastatic disease or not. One software was trained using 795 bone scans from European patients and the other with 904 bone scans from Japanese patients. The two CAD softwares were evaluated using the same group of 257 Japanese patients, who underwent bone scintigraphy because of suspected metastases of malignant tumors in 2009. The final diagnostic results made by clinicians were used as gold standard.

Results: The Japanese CAD software showed a higher specificity and accuracy compared to the European CAD software [81 vs. 57 % (p < 0.05) and 82 vs. 61 % (p < 0.05), respectively]. The sensitivity was 90 % for the Japanese CAD software and 83 % for the European CAD software (n.s).

Conclusion: The CAD software trained with a Japanese database showed significantly higher performance than the corresponding CAD software trained with a European database for the analysis of bone scans from Japanese patients. These results could at least partly be caused by the physical differences between Japanese and European patients resulting in less influence of attenuation in Japanese patients and possible different judgement of count intensities of hot spots.

Show MeSH
Related in: MedlinePlus