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Basics of particle therapy II: relative biological effectiveness.

Choi J, Kang JO - Radiat Oncol J (2012)

Bottom Line: Particle beam therapy has many potential advantages for cancer treatment without increasing severe side effects in normal tissue, these kinds of radiation have different biologic characteristics and have advantages over using conventional photon beam radiation during treatment.The relative biological effectiveness (RBE) is used for many biological, clinical endpoints among different radiation types and is the only convenient way to transfer the clinical experience in radiotherapy with photons to another type of radiation therapy.Thus this review describes the concerns about RBE related to particle beam to increase interests of the Korean radiation oncologists' society.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiation Oncology, Kyung Hee University School of Medicine, Seoul, Korea.

ABSTRACT
In the previous review, the physical aspect of heavy particles, with a focus on the carbon beam was introduced. Particle beam therapy has many potential advantages for cancer treatment without increasing severe side effects in normal tissue, these kinds of radiation have different biologic characteristics and have advantages over using conventional photon beam radiation during treatment. The relative biological effectiveness (RBE) is used for many biological, clinical endpoints among different radiation types and is the only convenient way to transfer the clinical experience in radiotherapy with photons to another type of radiation therapy. However, the RBE varies dependent on the energy of the beam, the fractionation, cell types, oxygenation status, and the biological endpoint studied. Thus this review describes the concerns about RBE related to particle beam to increase interests of the Korean radiation oncologists' society.

No MeSH data available.


The relative biological effectiveness (RBE) increases with fractionated radiation in contrast to the single fraction radiation (modified from Dasu and Toma-Dasu [39]). The complication probability of spread out Bragg peak may increase also (modified from Karger et al. [40]).
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Figure 4: The relative biological effectiveness (RBE) increases with fractionated radiation in contrast to the single fraction radiation (modified from Dasu and Toma-Dasu [39]). The complication probability of spread out Bragg peak may increase also (modified from Karger et al. [40]).

Mentions: With this equation, the authors compared the RBE of single fractionation and multiple fractionations. The authors showed that the clinically relevant RBE increased for greater doses per fraction when multiple fractions were applied, in contrast to the predictions from single-dose experiments (Fig. 4). Furthermore, the RBE of late-reacting tissues appeared to modify more quickly than that for early-reacting tissues. The authors concluded that the modification of the RBE with dose per fraction must be carefully taken into consideration when devising fractionated treatments with high LET radiation. They also emphasized that neglecting to do so may result in an avalanche of complications that could obscure the potential advantages of the therapeutic use of this radiation type.


Basics of particle therapy II: relative biological effectiveness.

Choi J, Kang JO - Radiat Oncol J (2012)

The relative biological effectiveness (RBE) increases with fractionated radiation in contrast to the single fraction radiation (modified from Dasu and Toma-Dasu [39]). The complication probability of spread out Bragg peak may increase also (modified from Karger et al. [40]).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3475957&req=5

Figure 4: The relative biological effectiveness (RBE) increases with fractionated radiation in contrast to the single fraction radiation (modified from Dasu and Toma-Dasu [39]). The complication probability of spread out Bragg peak may increase also (modified from Karger et al. [40]).
Mentions: With this equation, the authors compared the RBE of single fractionation and multiple fractionations. The authors showed that the clinically relevant RBE increased for greater doses per fraction when multiple fractions were applied, in contrast to the predictions from single-dose experiments (Fig. 4). Furthermore, the RBE of late-reacting tissues appeared to modify more quickly than that for early-reacting tissues. The authors concluded that the modification of the RBE with dose per fraction must be carefully taken into consideration when devising fractionated treatments with high LET radiation. They also emphasized that neglecting to do so may result in an avalanche of complications that could obscure the potential advantages of the therapeutic use of this radiation type.

Bottom Line: Particle beam therapy has many potential advantages for cancer treatment without increasing severe side effects in normal tissue, these kinds of radiation have different biologic characteristics and have advantages over using conventional photon beam radiation during treatment.The relative biological effectiveness (RBE) is used for many biological, clinical endpoints among different radiation types and is the only convenient way to transfer the clinical experience in radiotherapy with photons to another type of radiation therapy.Thus this review describes the concerns about RBE related to particle beam to increase interests of the Korean radiation oncologists' society.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiation Oncology, Kyung Hee University School of Medicine, Seoul, Korea.

ABSTRACT
In the previous review, the physical aspect of heavy particles, with a focus on the carbon beam was introduced. Particle beam therapy has many potential advantages for cancer treatment without increasing severe side effects in normal tissue, these kinds of radiation have different biologic characteristics and have advantages over using conventional photon beam radiation during treatment. The relative biological effectiveness (RBE) is used for many biological, clinical endpoints among different radiation types and is the only convenient way to transfer the clinical experience in radiotherapy with photons to another type of radiation therapy. However, the RBE varies dependent on the energy of the beam, the fractionation, cell types, oxygenation status, and the biological endpoint studied. Thus this review describes the concerns about RBE related to particle beam to increase interests of the Korean radiation oncologists' society.

No MeSH data available.