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Basics of particle therapy II: relative biological effectiveness.

Choi J, Kang JO - Radiat Oncol J (2012)

Bottom Line: Particle beam therapy has many potential advantages for cancer treatment without increasing severe side effects in normal tissue, these kinds of radiation have different biologic characteristics and have advantages over using conventional photon beam radiation during treatment.The relative biological effectiveness (RBE) is used for many biological, clinical endpoints among different radiation types and is the only convenient way to transfer the clinical experience in radiotherapy with photons to another type of radiation therapy.Thus this review describes the concerns about RBE related to particle beam to increase interests of the Korean radiation oncologists' society.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiation Oncology, Kyung Hee University School of Medicine, Seoul, Korea.

ABSTRACT
In the previous review, the physical aspect of heavy particles, with a focus on the carbon beam was introduced. Particle beam therapy has many potential advantages for cancer treatment without increasing severe side effects in normal tissue, these kinds of radiation have different biologic characteristics and have advantages over using conventional photon beam radiation during treatment. The relative biological effectiveness (RBE) is used for many biological, clinical endpoints among different radiation types and is the only convenient way to transfer the clinical experience in radiotherapy with photons to another type of radiation therapy. However, the RBE varies dependent on the energy of the beam, the fractionation, cell types, oxygenation status, and the biological endpoint studied. Thus this review describes the concerns about RBE related to particle beam to increase interests of the Korean radiation oncologists' society.

No MeSH data available.


Relative biological effectiveness (RBE) after multiple fractionation. The effects of high linear energy transfer (LET) radiation can be described using similar equations, either by using different α and β parameters or by applying dose modifying factors (DMF) to the parameters describing the response to low LET radiation. The DMF is drawn by experimental results.
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Figure 3: Relative biological effectiveness (RBE) after multiple fractionation. The effects of high linear energy transfer (LET) radiation can be described using similar equations, either by using different α and β parameters or by applying dose modifying factors (DMF) to the parameters describing the response to low LET radiation. The DMF is drawn by experimental results.

Mentions: In 2008, Dasu and Toma-Dasu [39] reported a clinical relevant RBE model warning about fractionated therapy with high LET radiation. The reliability on the transfer of tolerance and curative levels from low LET radiation to high LET radiation by using RBE was questioned. They introduced the dose modifying factor (DMF) concept to simplify the formula (Fig. 3). The effects of high LET radiation can be described using similar equations, either by using different α and β parameters or by applying DMF to the parameters describing the response to low LET radiation. DMF is drawn by experimental data.


Basics of particle therapy II: relative biological effectiveness.

Choi J, Kang JO - Radiat Oncol J (2012)

Relative biological effectiveness (RBE) after multiple fractionation. The effects of high linear energy transfer (LET) radiation can be described using similar equations, either by using different α and β parameters or by applying dose modifying factors (DMF) to the parameters describing the response to low LET radiation. The DMF is drawn by experimental results.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3475957&req=5

Figure 3: Relative biological effectiveness (RBE) after multiple fractionation. The effects of high linear energy transfer (LET) radiation can be described using similar equations, either by using different α and β parameters or by applying dose modifying factors (DMF) to the parameters describing the response to low LET radiation. The DMF is drawn by experimental results.
Mentions: In 2008, Dasu and Toma-Dasu [39] reported a clinical relevant RBE model warning about fractionated therapy with high LET radiation. The reliability on the transfer of tolerance and curative levels from low LET radiation to high LET radiation by using RBE was questioned. They introduced the dose modifying factor (DMF) concept to simplify the formula (Fig. 3). The effects of high LET radiation can be described using similar equations, either by using different α and β parameters or by applying DMF to the parameters describing the response to low LET radiation. DMF is drawn by experimental data.

Bottom Line: Particle beam therapy has many potential advantages for cancer treatment without increasing severe side effects in normal tissue, these kinds of radiation have different biologic characteristics and have advantages over using conventional photon beam radiation during treatment.The relative biological effectiveness (RBE) is used for many biological, clinical endpoints among different radiation types and is the only convenient way to transfer the clinical experience in radiotherapy with photons to another type of radiation therapy.Thus this review describes the concerns about RBE related to particle beam to increase interests of the Korean radiation oncologists' society.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiation Oncology, Kyung Hee University School of Medicine, Seoul, Korea.

ABSTRACT
In the previous review, the physical aspect of heavy particles, with a focus on the carbon beam was introduced. Particle beam therapy has many potential advantages for cancer treatment without increasing severe side effects in normal tissue, these kinds of radiation have different biologic characteristics and have advantages over using conventional photon beam radiation during treatment. The relative biological effectiveness (RBE) is used for many biological, clinical endpoints among different radiation types and is the only convenient way to transfer the clinical experience in radiotherapy with photons to another type of radiation therapy. However, the RBE varies dependent on the energy of the beam, the fractionation, cell types, oxygenation status, and the biological endpoint studied. Thus this review describes the concerns about RBE related to particle beam to increase interests of the Korean radiation oncologists' society.

No MeSH data available.