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Basics of particle therapy II: relative biological effectiveness.

Choi J, Kang JO - Radiat Oncol J (2012)

Bottom Line: Particle beam therapy has many potential advantages for cancer treatment without increasing severe side effects in normal tissue, these kinds of radiation have different biologic characteristics and have advantages over using conventional photon beam radiation during treatment.The relative biological effectiveness (RBE) is used for many biological, clinical endpoints among different radiation types and is the only convenient way to transfer the clinical experience in radiotherapy with photons to another type of radiation therapy.Thus this review describes the concerns about RBE related to particle beam to increase interests of the Korean radiation oncologists' society.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiation Oncology, Kyung Hee University School of Medicine, Seoul, Korea.

ABSTRACT
In the previous review, the physical aspect of heavy particles, with a focus on the carbon beam was introduced. Particle beam therapy has many potential advantages for cancer treatment without increasing severe side effects in normal tissue, these kinds of radiation have different biologic characteristics and have advantages over using conventional photon beam radiation during treatment. The relative biological effectiveness (RBE) is used for many biological, clinical endpoints among different radiation types and is the only convenient way to transfer the clinical experience in radiotherapy with photons to another type of radiation therapy. However, the RBE varies dependent on the energy of the beam, the fractionation, cell types, oxygenation status, and the biological endpoint studied. Thus this review describes the concerns about RBE related to particle beam to increase interests of the Korean radiation oncologists' society.

No MeSH data available.


Relative biological effectiveness (RBE) after single dose irradiation. If the fractional dose get closer to 0 (D→0), ln SL and ln SH become 1 (10°) and the β contribution becomes minimal (D→0, β→0). If the fractional dose becomes large enough, the ln SL becomes closer to ln SH, and α contribution becomes minimal (D→∞, α→0). According to linear quadratic model, RBE is maximal when dose→0. If the fractional dose increases, the RBE converges to a minimal value.
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Figure 2: Relative biological effectiveness (RBE) after single dose irradiation. If the fractional dose get closer to 0 (D→0), ln SL and ln SH become 1 (10°) and the β contribution becomes minimal (D→0, β→0). If the fractional dose becomes large enough, the ln SL becomes closer to ln SH, and α contribution becomes minimal (D→∞, α→0). According to linear quadratic model, RBE is maximal when dose→0. If the fractional dose increases, the RBE converges to a minimal value.

Mentions: According to LQ model, RBE is maximal when dose→0. At this point the α-component occupies the most effective component of the biologic effect. If the fractional dose increases, the RBE converges to a minimal value. RBEβ→0 is RBEmax and RBEα→0 is RBEmin (Fig. 2). This suggests that the difference between the RBEs is reduced with larger doses per fraction. However, larger fractional dose is related to an increase in complications.


Basics of particle therapy II: relative biological effectiveness.

Choi J, Kang JO - Radiat Oncol J (2012)

Relative biological effectiveness (RBE) after single dose irradiation. If the fractional dose get closer to 0 (D→0), ln SL and ln SH become 1 (10°) and the β contribution becomes minimal (D→0, β→0). If the fractional dose becomes large enough, the ln SL becomes closer to ln SH, and α contribution becomes minimal (D→∞, α→0). According to linear quadratic model, RBE is maximal when dose→0. If the fractional dose increases, the RBE converges to a minimal value.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3475957&req=5

Figure 2: Relative biological effectiveness (RBE) after single dose irradiation. If the fractional dose get closer to 0 (D→0), ln SL and ln SH become 1 (10°) and the β contribution becomes minimal (D→0, β→0). If the fractional dose becomes large enough, the ln SL becomes closer to ln SH, and α contribution becomes minimal (D→∞, α→0). According to linear quadratic model, RBE is maximal when dose→0. If the fractional dose increases, the RBE converges to a minimal value.
Mentions: According to LQ model, RBE is maximal when dose→0. At this point the α-component occupies the most effective component of the biologic effect. If the fractional dose increases, the RBE converges to a minimal value. RBEβ→0 is RBEmax and RBEα→0 is RBEmin (Fig. 2). This suggests that the difference between the RBEs is reduced with larger doses per fraction. However, larger fractional dose is related to an increase in complications.

Bottom Line: Particle beam therapy has many potential advantages for cancer treatment without increasing severe side effects in normal tissue, these kinds of radiation have different biologic characteristics and have advantages over using conventional photon beam radiation during treatment.The relative biological effectiveness (RBE) is used for many biological, clinical endpoints among different radiation types and is the only convenient way to transfer the clinical experience in radiotherapy with photons to another type of radiation therapy.Thus this review describes the concerns about RBE related to particle beam to increase interests of the Korean radiation oncologists' society.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiation Oncology, Kyung Hee University School of Medicine, Seoul, Korea.

ABSTRACT
In the previous review, the physical aspect of heavy particles, with a focus on the carbon beam was introduced. Particle beam therapy has many potential advantages for cancer treatment without increasing severe side effects in normal tissue, these kinds of radiation have different biologic characteristics and have advantages over using conventional photon beam radiation during treatment. The relative biological effectiveness (RBE) is used for many biological, clinical endpoints among different radiation types and is the only convenient way to transfer the clinical experience in radiotherapy with photons to another type of radiation therapy. However, the RBE varies dependent on the energy of the beam, the fractionation, cell types, oxygenation status, and the biological endpoint studied. Thus this review describes the concerns about RBE related to particle beam to increase interests of the Korean radiation oncologists' society.

No MeSH data available.