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Basics of particle therapy II: relative biological effectiveness.

Choi J, Kang JO - Radiat Oncol J (2012)

Bottom Line: Particle beam therapy has many potential advantages for cancer treatment without increasing severe side effects in normal tissue, these kinds of radiation have different biologic characteristics and have advantages over using conventional photon beam radiation during treatment.The relative biological effectiveness (RBE) is used for many biological, clinical endpoints among different radiation types and is the only convenient way to transfer the clinical experience in radiotherapy with photons to another type of radiation therapy.Thus this review describes the concerns about RBE related to particle beam to increase interests of the Korean radiation oncologists' society.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiation Oncology, Kyung Hee University School of Medicine, Seoul, Korea.

ABSTRACT
In the previous review, the physical aspect of heavy particles, with a focus on the carbon beam was introduced. Particle beam therapy has many potential advantages for cancer treatment without increasing severe side effects in normal tissue, these kinds of radiation have different biologic characteristics and have advantages over using conventional photon beam radiation during treatment. The relative biological effectiveness (RBE) is used for many biological, clinical endpoints among different radiation types and is the only convenient way to transfer the clinical experience in radiotherapy with photons to another type of radiation therapy. However, the RBE varies dependent on the energy of the beam, the fractionation, cell types, oxygenation status, and the biological endpoint studied. Thus this review describes the concerns about RBE related to particle beam to increase interests of the Korean radiation oncologists' society.

No MeSH data available.


Related in: MedlinePlus

Linear quadratic survival curve after single dose irradiation. The α-component represents non-repairable damage, while the β-component represents repairable damage. The damage caused by the β-component is repairable with time, so lowering the fractional dose results in lowering β-component damage to make α/β increase. Theoretically, a very low dose rate (dose/time) radiation resembles α curve. The α/β can be plotted when the equation (βD2-αD)/-D intersects the x-axis. RBE, relative biological effectiveness; LET, linear energy transfer.
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Figure 1: Linear quadratic survival curve after single dose irradiation. The α-component represents non-repairable damage, while the β-component represents repairable damage. The damage caused by the β-component is repairable with time, so lowering the fractional dose results in lowering β-component damage to make α/β increase. Theoretically, a very low dose rate (dose/time) radiation resembles α curve. The α/β can be plotted when the equation (βD2-αD)/-D intersects the x-axis. RBE, relative biological effectiveness; LET, linear energy transfer.

Mentions: Equations 4 to 11 of this section are based on the article "From DNA radiation damage to cell death: theoretical approches" by Ballarini [6] published in Journal of Nucleic Acid 2010, which is an open access article permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The target model, which was first developed in 1946 and revised in 1955 [7], had limitations that they made no assumption about the induction and repair of the initial DNA damage; this is now known to play a fundamental role in radiation-induced clonogenic death. Therefore, the linear-quadratic (LQ) model has been adopted as the model of choice to describe survival curves (Fig. 1) [8]. In 1973, Chadwick and Leenhouts [9] developed a molecular model, which is now known as the LQ model.


Basics of particle therapy II: relative biological effectiveness.

Choi J, Kang JO - Radiat Oncol J (2012)

Linear quadratic survival curve after single dose irradiation. The α-component represents non-repairable damage, while the β-component represents repairable damage. The damage caused by the β-component is repairable with time, so lowering the fractional dose results in lowering β-component damage to make α/β increase. Theoretically, a very low dose rate (dose/time) radiation resembles α curve. The α/β can be plotted when the equation (βD2-αD)/-D intersects the x-axis. RBE, relative biological effectiveness; LET, linear energy transfer.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3475957&req=5

Figure 1: Linear quadratic survival curve after single dose irradiation. The α-component represents non-repairable damage, while the β-component represents repairable damage. The damage caused by the β-component is repairable with time, so lowering the fractional dose results in lowering β-component damage to make α/β increase. Theoretically, a very low dose rate (dose/time) radiation resembles α curve. The α/β can be plotted when the equation (βD2-αD)/-D intersects the x-axis. RBE, relative biological effectiveness; LET, linear energy transfer.
Mentions: Equations 4 to 11 of this section are based on the article "From DNA radiation damage to cell death: theoretical approches" by Ballarini [6] published in Journal of Nucleic Acid 2010, which is an open access article permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The target model, which was first developed in 1946 and revised in 1955 [7], had limitations that they made no assumption about the induction and repair of the initial DNA damage; this is now known to play a fundamental role in radiation-induced clonogenic death. Therefore, the linear-quadratic (LQ) model has been adopted as the model of choice to describe survival curves (Fig. 1) [8]. In 1973, Chadwick and Leenhouts [9] developed a molecular model, which is now known as the LQ model.

Bottom Line: Particle beam therapy has many potential advantages for cancer treatment without increasing severe side effects in normal tissue, these kinds of radiation have different biologic characteristics and have advantages over using conventional photon beam radiation during treatment.The relative biological effectiveness (RBE) is used for many biological, clinical endpoints among different radiation types and is the only convenient way to transfer the clinical experience in radiotherapy with photons to another type of radiation therapy.Thus this review describes the concerns about RBE related to particle beam to increase interests of the Korean radiation oncologists' society.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiation Oncology, Kyung Hee University School of Medicine, Seoul, Korea.

ABSTRACT
In the previous review, the physical aspect of heavy particles, with a focus on the carbon beam was introduced. Particle beam therapy has many potential advantages for cancer treatment without increasing severe side effects in normal tissue, these kinds of radiation have different biologic characteristics and have advantages over using conventional photon beam radiation during treatment. The relative biological effectiveness (RBE) is used for many biological, clinical endpoints among different radiation types and is the only convenient way to transfer the clinical experience in radiotherapy with photons to another type of radiation therapy. However, the RBE varies dependent on the energy of the beam, the fractionation, cell types, oxygenation status, and the biological endpoint studied. Thus this review describes the concerns about RBE related to particle beam to increase interests of the Korean radiation oncologists' society.

No MeSH data available.


Related in: MedlinePlus