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A synchronous occurrence of urothelial carcinoma with abundant myxoid stroma and inverted papilloma of the urinary bladder.

Behzato─člu K, Yildiz P, Oznur M, Bozkurt ER - Rare Tumors (2012)

Bottom Line: About 90 to 100% nuclear staining was observed with p63, p53, and Ki-67.A second neoplasm with a flat overlying urothelial epithelium and a complete inverted cellular growth pattern was also noted.Considering histological, histochemical, and immunohistochemical findings, a diagnosis of synchronous urothelial carcinoma with abundant myxoid stroma and inverted papilloma was made.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Istanbul Education and Research Hospital, Ministry of Health, Istanbul;

ABSTRACT
Abundant myxoid stroma rarely occurs in urothelial carcinomas, and may cause diagnostic challenges when cells with eosinophilic cytoplasm forming nests and cords in a myxoid background are seen, particularly in the absence of typical carcinomatous appearance. Microscopic examination of transurethral resection specimen of a 71-year-old male patient revealed non-cohesive oval or elongated tumor cells with eosinophilic cytoplasm arranged in cord-like filigree pattern in an abundant myxoid stroma. Immunohistochemically the tumor was positive for cytokeratin 7, cytokeratin 20, and 34BE12. About 90 to 100% nuclear staining was observed with p63, p53, and Ki-67. A second neoplasm with a flat overlying urothelial epithelium and a complete inverted cellular growth pattern was also noted. The neoplasm exhibited less than 2% and 10% nuclear staining with Ki-67 and p53, respectively. Considering histological, histochemical, and immunohistochemical findings, a diagnosis of synchronous urothelial carcinoma with abundant myxoid stroma and inverted papilloma was made.

No MeSH data available.


Related in: MedlinePlus

Urothelial carcinoma with abondant myxoid stroma diffuse nuclear p63 immunoreactivity.
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Figure 6: Urothelial carcinoma with abondant myxoid stroma diffuse nuclear p63 immunoreactivity.

Mentions: Intense staining with alcian blue pH 2.5 (Figure 5) periodic acid-schiff, and mucicarminewas found in the myxoid areas of the stroma. The cellular structures within the myxoid stroma exhibited 90 to 100% nuclear staining with p63 (Figure 6), p53 and Ki-67; strong cytoplasmic staining with cytokeratin 20 (CK20), cytokeratin 7 (CK7) and high molecular weight keratin (34BE12) (Figure 7); and no staining with S-100, calponin, Glial fibrillary acidic protein (GFAP), CDX2, prostate specific antigen (PSA), and leukocyte common antigen (LCA).


A synchronous occurrence of urothelial carcinoma with abundant myxoid stroma and inverted papilloma of the urinary bladder.

Behzato─člu K, Yildiz P, Oznur M, Bozkurt ER - Rare Tumors (2012)

Urothelial carcinoma with abondant myxoid stroma diffuse nuclear p63 immunoreactivity.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3475952&req=5

Figure 6: Urothelial carcinoma with abondant myxoid stroma diffuse nuclear p63 immunoreactivity.
Mentions: Intense staining with alcian blue pH 2.5 (Figure 5) periodic acid-schiff, and mucicarminewas found in the myxoid areas of the stroma. The cellular structures within the myxoid stroma exhibited 90 to 100% nuclear staining with p63 (Figure 6), p53 and Ki-67; strong cytoplasmic staining with cytokeratin 20 (CK20), cytokeratin 7 (CK7) and high molecular weight keratin (34BE12) (Figure 7); and no staining with S-100, calponin, Glial fibrillary acidic protein (GFAP), CDX2, prostate specific antigen (PSA), and leukocyte common antigen (LCA).

Bottom Line: About 90 to 100% nuclear staining was observed with p63, p53, and Ki-67.A second neoplasm with a flat overlying urothelial epithelium and a complete inverted cellular growth pattern was also noted.Considering histological, histochemical, and immunohistochemical findings, a diagnosis of synchronous urothelial carcinoma with abundant myxoid stroma and inverted papilloma was made.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Istanbul Education and Research Hospital, Ministry of Health, Istanbul;

ABSTRACT
Abundant myxoid stroma rarely occurs in urothelial carcinomas, and may cause diagnostic challenges when cells with eosinophilic cytoplasm forming nests and cords in a myxoid background are seen, particularly in the absence of typical carcinomatous appearance. Microscopic examination of transurethral resection specimen of a 71-year-old male patient revealed non-cohesive oval or elongated tumor cells with eosinophilic cytoplasm arranged in cord-like filigree pattern in an abundant myxoid stroma. Immunohistochemically the tumor was positive for cytokeratin 7, cytokeratin 20, and 34BE12. About 90 to 100% nuclear staining was observed with p63, p53, and Ki-67. A second neoplasm with a flat overlying urothelial epithelium and a complete inverted cellular growth pattern was also noted. The neoplasm exhibited less than 2% and 10% nuclear staining with Ki-67 and p53, respectively. Considering histological, histochemical, and immunohistochemical findings, a diagnosis of synchronous urothelial carcinoma with abundant myxoid stroma and inverted papilloma was made.

No MeSH data available.


Related in: MedlinePlus