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Extra-gastrointestinal stromal tumor of the omentum: a rare case report and review of the literature.

Fagkrezos D, Touloumis Z, Giannila M, Penlidis C, Papaparaskeva K, Triantopoulou C - Rare Tumors (2012)

Bottom Line: Clinical course and the prognostic factors of such lesions will also be discussed.In most cases, a pre-operative diagnosis is not possible, and the patient undergoes a surgical operation for the generic diagnosis of abdominal mass.During the intervention it is important to achieve a complete removal of the mass and to examine every possible adhesion to the gastrointestinal wall.

View Article: PubMed Central - PubMed

Affiliation: Radiology Department, Konstantopouleio General Hospital, Aghias Olgas;

ABSTRACT
Gastrointestinal stromal tumors (GIST) are uncommon mesenchymal spindle-cell or epithelioid neoplasms, located mainly with higher frequency in the stomach and small bowel. GISTs represent the majority of primary non-epithelial neoplasms of the digestive tract, most frequently expressing the KIT protein a transmembrane tyrosine kinase receptor for stem cell factor. Extra-gastrointestinal stromal tumors tend to present In fewer than 5% of cases; they originate primarily from the mesentery, omentum or peritoneum. Furthermore, these extra-gastrointestinal tumors (EGIST) tend to be more common in patients over the age of 50 years. EGISTs are neoplasms with overlapping immunohistological features, occurring in the abdomen outside the gastrointestinal tract with no connection to the gastric or intestinal wall. We describe here a rare case of EGIST of the lesser omentum and report the clinical, macroscopic, immunohistological and radiological features of an EGIST arising in the lesser omentum of a 63-year old man. Clinical course and the prognostic factors of such lesions will also be discussed. EGISTs in the lesser omentum can grow slowly and remain silent despite a large tumor size. In most cases, a pre-operative diagnosis is not possible, and the patient undergoes a surgical operation for the generic diagnosis of abdominal mass. During the intervention it is important to achieve a complete removal of the mass and to examine every possible adhesion to the gastrointestinal wall.

No MeSH data available.


Related in: MedlinePlus

Microscopic imaging. Diffuse positive immunostain for c-kit 400×.
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Related In: Results  -  Collection


getmorefigures.php?uid=PMC3475951&req=5

Figure 5: Microscopic imaging. Diffuse positive immunostain for c-kit 400×.

Mentions: Microscopically, the tumor was composed of spindle to ovoid cells arranged in broad fascicles. The nuclei were ovoid and focally elongated, and showed mild to moderate atypia. The mitotic figures were fewer than 5 per 50 high power fields (HPF) (Figure 4). The MIB-1 index, defined as the perentage of MIB-1 positive tumor cells seen in 500 tumor cells, was less than 10%. Immunohistochemically, the tumor cells showed diffuse and strong positivity for c-kit (CD117), smooth muscle actin (SMA) and human hematopoietic progenitor cell antigen (CD34), with negative internal control marker, as well as weak and focal positivity for caldesmon. Immunostains for desmin and S-100 protein were negative (Figure 5).


Extra-gastrointestinal stromal tumor of the omentum: a rare case report and review of the literature.

Fagkrezos D, Touloumis Z, Giannila M, Penlidis C, Papaparaskeva K, Triantopoulou C - Rare Tumors (2012)

Microscopic imaging. Diffuse positive immunostain for c-kit 400×.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3475951&req=5

Figure 5: Microscopic imaging. Diffuse positive immunostain for c-kit 400×.
Mentions: Microscopically, the tumor was composed of spindle to ovoid cells arranged in broad fascicles. The nuclei were ovoid and focally elongated, and showed mild to moderate atypia. The mitotic figures were fewer than 5 per 50 high power fields (HPF) (Figure 4). The MIB-1 index, defined as the perentage of MIB-1 positive tumor cells seen in 500 tumor cells, was less than 10%. Immunohistochemically, the tumor cells showed diffuse and strong positivity for c-kit (CD117), smooth muscle actin (SMA) and human hematopoietic progenitor cell antigen (CD34), with negative internal control marker, as well as weak and focal positivity for caldesmon. Immunostains for desmin and S-100 protein were negative (Figure 5).

Bottom Line: Clinical course and the prognostic factors of such lesions will also be discussed.In most cases, a pre-operative diagnosis is not possible, and the patient undergoes a surgical operation for the generic diagnosis of abdominal mass.During the intervention it is important to achieve a complete removal of the mass and to examine every possible adhesion to the gastrointestinal wall.

View Article: PubMed Central - PubMed

Affiliation: Radiology Department, Konstantopouleio General Hospital, Aghias Olgas;

ABSTRACT
Gastrointestinal stromal tumors (GIST) are uncommon mesenchymal spindle-cell or epithelioid neoplasms, located mainly with higher frequency in the stomach and small bowel. GISTs represent the majority of primary non-epithelial neoplasms of the digestive tract, most frequently expressing the KIT protein a transmembrane tyrosine kinase receptor for stem cell factor. Extra-gastrointestinal stromal tumors tend to present In fewer than 5% of cases; they originate primarily from the mesentery, omentum or peritoneum. Furthermore, these extra-gastrointestinal tumors (EGIST) tend to be more common in patients over the age of 50 years. EGISTs are neoplasms with overlapping immunohistological features, occurring in the abdomen outside the gastrointestinal tract with no connection to the gastric or intestinal wall. We describe here a rare case of EGIST of the lesser omentum and report the clinical, macroscopic, immunohistological and radiological features of an EGIST arising in the lesser omentum of a 63-year old man. Clinical course and the prognostic factors of such lesions will also be discussed. EGISTs in the lesser omentum can grow slowly and remain silent despite a large tumor size. In most cases, a pre-operative diagnosis is not possible, and the patient undergoes a surgical operation for the generic diagnosis of abdominal mass. During the intervention it is important to achieve a complete removal of the mass and to examine every possible adhesion to the gastrointestinal wall.

No MeSH data available.


Related in: MedlinePlus