Limits...
Primary testicular lymphoma with cardiac involvement in an immunocompetent patient: case report and a concise review of literature.

Dahiya S, Ooi WB, Mallidi J, Sivalingam S, Steingart R - Rare Tumors (2012)

Bottom Line: Primary testicular lymphoma (PTL) is a rare testicular tumor representing less than 9% of all testicular cancers.PTL usually tends to spread to or relapse at nodal structures or extra-nodal sites such as contralateral testes, central nervous system, skin, lung, pleura, waldeyer's ring and soft tissues.A brief review of literature focusing on various aspects of management of primary testicular lymphoma and lymphomatous involvement of heart is also discussed.

View Article: PubMed Central - PubMed

Affiliation: Baystate Medical Center, Tufts University School of Medicine, Springfield, MA, USA.

ABSTRACT
Primary testicular lymphoma (PTL) is a rare testicular tumor representing less than 9% of all testicular cancers. PTL usually tends to spread to or relapse at nodal structures or extra-nodal sites such as contralateral testes, central nervous system, skin, lung, pleura, waldeyer's ring and soft tissues. We present a case of PTL with huge left atrial mass, an extremely unusual site of involvement. Early disease usually carries a good prognosis, whereas advanced stage carries an extremely poor prognosis. Herein, we report the complete remission to date in a patient with advanced stage PTL with huge left atrial mass, treated with systemic rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone and intrathecal methotrexate. A brief review of literature focusing on various aspects of management of primary testicular lymphoma and lymphomatous involvement of heart is also discussed.

No MeSH data available.


Related in: MedlinePlus

Positron emission tomography-computed tomography one year after treatment completion, demonstrating complete metabolic response.
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3475950&req=5

Figure 3: Positron emission tomography-computed tomography one year after treatment completion, demonstrating complete metabolic response.

Mentions: During the hospital stay, the patient had multiple episodes of symptomatic hypotension, thought to be secondary to intracardiac mass. Given the symptomatic nature of the disease, patient was started on chemotherapy on an urgent basis. He was commenced on systemic rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) and prophylactic intrathecal methotrexate. A repeat PET-CT done after 2 cycles showed near complete metabolic response to treatment (Figure 3). He completed a total of 6 cycles of R-CHOP and 4 cycles of prophylactic intrathecal methotrexate. An echocardiogram at the end of the treatment revealed complete resolution of the left atrial mass. Almost over a year later after treatment completion, patient's disease is still in remission as documented by a normal PET-CT scan.


Primary testicular lymphoma with cardiac involvement in an immunocompetent patient: case report and a concise review of literature.

Dahiya S, Ooi WB, Mallidi J, Sivalingam S, Steingart R - Rare Tumors (2012)

Positron emission tomography-computed tomography one year after treatment completion, demonstrating complete metabolic response.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3475950&req=5

Figure 3: Positron emission tomography-computed tomography one year after treatment completion, demonstrating complete metabolic response.
Mentions: During the hospital stay, the patient had multiple episodes of symptomatic hypotension, thought to be secondary to intracardiac mass. Given the symptomatic nature of the disease, patient was started on chemotherapy on an urgent basis. He was commenced on systemic rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) and prophylactic intrathecal methotrexate. A repeat PET-CT done after 2 cycles showed near complete metabolic response to treatment (Figure 3). He completed a total of 6 cycles of R-CHOP and 4 cycles of prophylactic intrathecal methotrexate. An echocardiogram at the end of the treatment revealed complete resolution of the left atrial mass. Almost over a year later after treatment completion, patient's disease is still in remission as documented by a normal PET-CT scan.

Bottom Line: Primary testicular lymphoma (PTL) is a rare testicular tumor representing less than 9% of all testicular cancers.PTL usually tends to spread to or relapse at nodal structures or extra-nodal sites such as contralateral testes, central nervous system, skin, lung, pleura, waldeyer's ring and soft tissues.A brief review of literature focusing on various aspects of management of primary testicular lymphoma and lymphomatous involvement of heart is also discussed.

View Article: PubMed Central - PubMed

Affiliation: Baystate Medical Center, Tufts University School of Medicine, Springfield, MA, USA.

ABSTRACT
Primary testicular lymphoma (PTL) is a rare testicular tumor representing less than 9% of all testicular cancers. PTL usually tends to spread to or relapse at nodal structures or extra-nodal sites such as contralateral testes, central nervous system, skin, lung, pleura, waldeyer's ring and soft tissues. We present a case of PTL with huge left atrial mass, an extremely unusual site of involvement. Early disease usually carries a good prognosis, whereas advanced stage carries an extremely poor prognosis. Herein, we report the complete remission to date in a patient with advanced stage PTL with huge left atrial mass, treated with systemic rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone and intrathecal methotrexate. A brief review of literature focusing on various aspects of management of primary testicular lymphoma and lymphomatous involvement of heart is also discussed.

No MeSH data available.


Related in: MedlinePlus